公开(公告)号：WO2017201407A1

公开(公告)日：2017-11-23

申请号：PCT/US2017/033542

申请日：2017-05-19

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ARTZI, Natalie ,  OLIVA JORGE, Nuria ,  ZHANG, Yi ,  CONDE, Joao

IPC: C07D309/14 ,  A61K9/06 ,  A61K9/10 ,  A61K31/351 ,  A61K31/704 ,  A61K47/36 ,  A61P35/00

Abstract: A hydrogel particle comprising: cross-linked dextran aldehyde (oxidized dextran), comprising the redox sensitive disulfide cross-linker cystamine (2,2'-disulfanediyldiethanamine), the anti-tumor agent doxorubicin conjugated to the cross-linked polymer by a pH sensitive imine bond and the cell penetrating peptide RGD, for use in chemotherapy.

Abstract translation: 水凝胶颗粒包含：交联葡聚糖醛（氧化葡聚糖），其包含氧化还原敏感的二硫化物交联剂胱胺（2,2'-二硫烷二基二乙胺），抗肿瘤剂多柔比星与 交联聚合物通过pH敏感的亚胺键和细胞穿透肽RGD用于化学疗法。

公开(公告)号：WO2016134232A1

公开(公告)日：2016-08-25

申请号：PCT/US2016/018632

申请日：2016-02-19

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ARTZI, Natalie ,  CONDE, Joao ,  OLIVA, Nuria

IPC: A61K33/24 ,  A61K31/713 ,  A61K47/48

CPC classification number: A61K47/48884 ,  A61K31/513 ,  A61K31/713 ,  A61K33/24 ,  A61K47/6923 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0065 ,  A61K49/0093 ,  A61K2300/00 ,  A61K31/24

Abstract: Theranostic nanoprobes are provided for overcoming cancer multidrug resistance, and methods for treating biological tissue, including cancerous tissue. The theranostic nanoprobes may include gold nanoparticles functionalized with DNA-hairpin. The DNA-hairpin may be configured to hybridize to a complementary target, which may silence or lessen the multidrug resistance of cancer cells. The theranostic nanoprobes may be configured to release a chemotherapeutic agent upon hybridization of the DNA-hairpin to a target molecule.

Abstract translation: 提供了纳曲酮纳米探针以克服癌症多药耐药性，以及用于治疗生物组织（包括癌组织）的方法。 衍生物纳米探针可以包括用DNA-发夹官能化的金纳米颗粒。 DNA发夹可以被配置为与互补靶物杂交，其可以沉默或减轻癌细胞的多药耐药性。 衍生物纳米探针可以被配置为在DNA-发夹与靶分子杂交时释放化学治疗剂。

公开(公告)号：WO2017197133A1

公开(公告)日：2017-11-16

申请号：PCT/US2017/032192

申请日：2017-05-11

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ARTZI, Natalie ,  CONDE, Joao ,  OLIVA, Nuria

IPC: A61K47/62 ,  A61K47/69

CPC classification number: A61K47/6929 ,  A61K31/713 ,  A61K39/44 ,  A61K41/0042 ,  A61K47/60 ,  A61K47/62 ,  A61K47/6845 ,  A61K47/6903 ,  A61K47/6923 ,  A61M5/19 ,  A61N5/062 ,  A61P35/00 ,  B82Y5/00 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/76 ,  C12N15/1135 ,  C12N2310/14 ,  C12N2310/3513 ,  C12N2320/32 ,  C12N2760/16122

Abstract: Provided herein are functionalized nanoparticles and compositions containing functionalized nanoparticles. The functionalized nanoparticles include a first metal nanoparticle functionalized with a drug and a targeting biomolecule, and a second metal nanoparticle functionalized with an siRNA and a targeting biomolecule. The compositions include the first metal nanoparticle and the second metal nanoparticle. Kits and methods of drug delivery also are provided.

Abstract translation: 本文提供官能化纳米粒子和含有官能化纳米粒子的组合物。 官能化的纳米粒子包括用药物和靶向生物分子官能化的第一金属纳米粒子和用siRNA和靶向生物分子官能化的第二金属纳米粒子。 该组合物包含第一金属纳米颗粒和第二金属纳米颗粒。 还提供了药物递送的试剂盒和方法。