公开(公告)号：WO2016027073A1

公开(公告)日：2016-02-25

申请号：PCT/GB2015/052390

申请日：2015-08-18

Applicant: MICROMASS UK LIMITED

Inventor： BAJIC, Stevan

IPC: H01J49/04 ,  H01J49/16

CPC classification number: H01J49/045 ,  H01J49/16

Abstract: There is provided an ion source comprising one or more nebulisers (1) and one or more targets (50), wherein said one or more nebulisers (1) are arranged and adapted to emit, in use, a stream predominantly of droplets which are caused to impact upon said one or more targets (50) and to ionise said droplets to form a plurality of ions, wherein said one or more targets (50) further comprise one or more structures (14) configured to disturb gas flowing along a surface of said one or more targets (50).

Abstract translation: 提供了包括一个或多个雾化器（1）和一个或多个靶（50）的离子源，其中所述一个或多个雾化器（1）被布置并适于在使用中发射主要由液滴引起的流 冲击所述一个或多个靶（50）并离子化所述液滴以形成多个离子，其中所述一个或多个靶（50）还包括一个或多个结构（14），其构造成阻止沿着 所述一个或多个目标（50）。

公开(公告)号：WO2015128652A3

公开(公告)日：2015-09-03

申请号：PCT/GB2015/050556

申请日：2015-02-26

Applicant: MICROMASS UK LIMITED

Inventor： BAJIC, Stevan

IPC: H01J49/04 ,  H01J49/16

Abstract: An ion source is provided comprising one or more nebulisers (1) and one or more targets (5), wherein the one or more nebulisers (1) are arranged and adapted to emit, in use, a stream predominantly of droplets which are caused to impact upon the one or more targets (5) and to ionise the droplets to form a plurality of ions. The ion source further comprises one or more electrodes (10) arranged adjacent to and/or attached to the one or more targets (5) wherein the one or more electrodes (10) comprise one or more apertures, notches or cut-outs (12) wherein at least some of the plurality of ions pass, in use, through the one or more apertures, notches or cut-outs (12).

公开(公告)号：WO2015128652A2

公开(公告)日：2015-09-03

申请号：PCT/GB2015/050556

申请日：2015-02-26

Applicant: MICROMASS UK LIMITED

Inventor： BAJIC, Stevan

CPC classification number: H01J49/045 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/142 ,  H01J49/16

Abstract: An ion source is provided comprising one or more nebulisers (1) and one or more targets (5), wherein the one or more nebulisers (1) are arranged and adapted to emit, in use, a stream predominantly of droplets which are caused to impact upon the one or more targets (5) and to ionise the droplets to form a plurality of ions. The ion source further comprises one or more electrodes (10) arranged adjacent to and/or attached to the one or more targets (5) wherein the one or more electrodes (10) comprise one or more apertures, notches or cut-outs (12) wherein at least some of the plurality of ions pass, in use, through the one or more apertures, notches or cut-outs (12).

Abstract translation: 提供了包括一个或多个雾化器（1）和一个或多个靶（5）的离子源，其中所述一个或多个雾化器（1）被布置并适于在使用中发射主要由液滴引起的液滴 影响一个或多个靶（5）并使液滴离子以形成多个离子。 离子源还包括一个或多个电极（10），其邻近于和/或附接到一个或多个靶（5），其中所述一个或多个电极（10）包括一个或多个孔，凹口或切口（12 ），其中所述多个离子中的至少一些在使用中通过所述一个或多个孔，凹口或切口（12）。

公开(公告)号：WO2019219748A1

公开(公告)日：2019-11-21

申请号：PCT/EP2019/062485

申请日：2019-05-15

Applicant: MICROMASS UK LIMITED

Inventor： BAJIC, Stevan

IPC: H01J49/04 ,  H01J49/16

Abstract: An impact ionisation spray or electrospray ionisation ion source comprising a nebuliser (30) having a first conduit (11) for providing a liquid sample and a second conduit (10) for providing a nebulisation gas in order to nebulise the liquid sample is disclosed. The first conduit (11) and second conduit (10) are of unitary construction with each other and may be made from glass. The ion source can provide a consistent and/or predictable spray profile for the nebulised sample.

公开(公告)号：WO2019122358A3

公开(公告)日：2019-06-27

申请号：PCT/EP2018/086652

申请日：2018-12-21

Applicant: MICROMASS UK LIMITED

Inventor： BAJIC, Stevan ,  DOUCE, David S.

IPC: H01J49/04 ,  H01J49/14 ,  H01J27/20

Abstract: A method of ionizing a sample is disclosed that comprises heating a sample so that analyte is released from the sample, producing charged particles such as charged droplets downstream of the sample, and using the charged particles to ionize at least some of the analyte released from the sample so as to produce analyte ions.

公开(公告)号：WO2014064399A1

公开(公告)日：2014-05-01

申请号：PCT/GB2012/052652

申请日：2012-10-25

Applicant: MICROMASS UK LIMITED

Inventor： BAJIC, Stevan ,  DOUCE, David ,  JONES, Gordon

IPC: H01J49/04 ,  H01J49/16

CPC classification number: H01J49/045 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/0454 ,  H01J49/061 ,  H01J49/16 ,  H01J49/161

Abstract: An ion source is disclosed comprising a nebuliser (1) and a target (10). The nebuliser (1) is arranged and adapted to emit, in use, a stream of analyte droplets which are caused to impact upon the target (10) and to ionise analyte to form a plurality of analyte ions. The target (10) is vibrated by a piezo-electric vibration device to reduce the size of resultant secondary droplets.

Abstract translation: 公开了一种包括雾化器（1）和靶（10）的离子源。 雾化器（1）被布置并适于在使用中发射被分析物液滴流，其被撞击到靶（10）上并离子化分析物以形成多个分析物离子。 目标（10）由压电振动装置振动以减小所产生的二次液滴的尺寸。

公开(公告)号：WO2020012163A1

公开(公告)日：2020-01-16

申请号：PCT/GB2019/051891

申请日：2019-07-04

Applicant: MICROMASS UK LIMITED

Inventor： BAJIC, Stevan ,  BROWN, Jeffery Mark

IPC: H01J49/16 ,  H01J49/04

Abstract: An ion source is provided comprising a nebuliser or electrospray probe (1) for nebulising a sample and an impact surface or target electrode (5). The impact surface or target electrode (5) comprises a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal. Also provided is an ion source comprising a nebuliser or electrospray probe with a central wire comprising a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal. Adducts with relatively heavy metals result in simplified multiply-charged mass spectra that are easier to interpret.

公开(公告)号：WO2015128661A1

公开(公告)日：2015-09-03

申请号：PCT/GB2015/050566

申请日：2015-02-26

Applicant: MICROMASS UK LIMITED

Inventor： BAJIC, Stevan

IPC: H01J49/14

CPC classification number: H01J49/142

Abstract: An ion source is disclosed comprising a nebuliser (1) arranged and adapted to emit a liquid spray, a first target (5) arranged downstream of the nebuliser (1), wherein the liquid spray is arranged to impact upon the first target (5), and a sample target (10) arranged downstream of the first target (5), wherein a sample to be analysed is provided at the sample target (10).

Abstract translation: 公开了一种离子源，其包括布置并适于发射液体喷雾的雾化器（1），布置在雾化器（1）下游的第一靶（5），其中液体喷射被布置成撞击第一靶（5） 以及布置在所述第一靶（5）的下游的样品靶（10），其中在所述样品靶（10）处设置待分析样品。

公开(公告)号：WO2015040386A1

公开(公告)日：2015-03-26

申请号：PCT/GB2014/052819

申请日：2014-09-17

Applicant: MICROMASS UK LIMITED

Inventor： BAJIC, Stevan ,  GORDON, David ,  KENNY, Daniel James ,  MOULDS, Richard Barrington ,  O'BRIEN, Stephen ,  TRIVETT, Ian ,  WHYATT, Kate

IPC: H01J49/16

CPC classification number: H01J49/167 ,  H01J49/0027 ,  H01J49/044 ,  H01J49/165

Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate > 200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube 3 at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube 2 is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube 3 and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater 4 arranged and adapted to heat the desolvation gas to a temperature≥ 100° C and a fourth device arranged and adapted to supply a cone gas to the gas cone 6 at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.

Abstract translation: 公开了一种质谱仪，其包括大气压力界面，其包括具有入口孔的气体锥体6，其中气体锥体6具有沿x轴布置的第一纵向轴线和电喷雾离子源，其包括具有出口的第一毛细管2 并且具有第二纵向轴线和围绕第一毛细管2的第二毛细管3.质谱仪还包括去溶剂化气体供应管和布置成适于经由第一毛细管2供应分析物液体的第一装置，使得 液体以>200μL/ min的流速离开第一毛细管2的出口。 质谱仪还包括第二装置，其布置并适于经由第二毛细管3以80-150L / hr的流速提供喷雾器气体，其中第一毛细管2的出口以一定距离 从气体入口孔的中心测量的沿着x轴的x mm，沿着从气体入口孔的中心测量的y轴的距离y mm和沿着z轴的距离z mm作为 从气锥入口孔的中心测量。 x轴，y轴和z轴相互正交。 去溶剂化气体供应管围绕第二毛细管3，质谱仪还包括第三装置，其布置并适于经由去溶剂化气体供应管以400-1200L / hr的流量供应去溶剂化气体，加热器 4，其布置并适于将去溶剂化气体加热至≥100℃的温度，以及第四装置，其布置并适于以40-80L / hr的流速向锥形锥体6供应锥形气体，并且其中x为 在2.0-5.0mm的范围内，并且其中z / x的比率在1-5:1的范围内。

公开(公告)号：WO2013093517A1

公开(公告)日：2013-06-27

申请号：PCT/GB2012/053258

申请日：2012-12-21

Applicant: MICROMASS UK LIMITED

Inventor： BAJIC, Stevan

IPC: H01J49/04 ,  H01J49/14

CPC classification number: G01N30/7266 ,  G01N27/44704 ,  G01N27/622 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/0454 ,  H01J49/10 ,  H01J49/16 ,  H01J49/165

Abstract: A mass spectrometer is disclosed comprising a separation device arranged and adapted to emit an eluent over a period of time. The separation device preferably comprises a Capillary Electrophoresis ("CE") separation device. The mass spectrometer further comprises a nebuliser (2) and a target (11). Eluent emitted by the separation device is nebulised, in use, by the nebuliser wherein a stream of analyte droplets are directed to impact upon the target (11) so as to ionise the analyte to form a plurality of analyte ions.

Abstract translation: 公开了一种质谱仪，其包括布置并适于在一段时间内发射洗脱液的分离装置。 分离装置优选包括毛细管电泳（“CE”）分离装置。 质谱仪还包括雾化器（2）和靶（11）。 由分离装置发射的洗脱液在使用中由喷雾器雾化，其中分析物液滴流被引导以撞击靶（11），以便使分析物离子化以形成多个分析物离子。