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    METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER
    5.
    发明申请
    METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER 审中-公开
    在质谱仪中提高灵敏度的方法和装置

    公开(公告)号：WO2013114196A1

    公开(公告)日：2013-08-08

    申请号：PCT/IB2013/000137

    申请日：2013-02-01

    申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    发明人： JAVAHERI, Hassan ,  THOMSON, Bruce, A.

    IPC分类号： H01J49/26 ,  H01J49/10

    CPC分类号： H01J49/063 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/062 ,  H01J49/24 ,  H01J49/26

    摘要： Ions are generated in a high pressure region and are passed into a vacuum chamber having an inlet and an exit aperture. The configuration of the inlet aperture and the pressure difference between the high pressure region and the vacuum chamber provides a supersonic free jet expansion that has a barrel shock of predetermined diameter. At least one ion guide is provided between the inlet and exit apertures having a predetermined cross-section defining an internal volume wherein the cross-section of the at least one ion guide is sized to be at least 50% of the predetermined diameter of the barrel shock of the supersonic free jet expansion. An RF voltage is provided to the at least one ion guide. Radial gas conductance is reduced in a first section of the at least one ion guide for damping shock waves resulting from the supersonic free jet expansion.

    摘要翻译： 离子在高压区域产生，并且进入具有入口和出口的真空室。 入口孔的构型和高压区域与真空室之间的压力差提供超音速自由射流膨胀，其具有预定直径的桶形冲击。 至少一个离子导向件设置在入口孔和出口孔之间，具有限定内部容积的预定横截面，其中至少一个离子导向件的横截面的尺寸被设定为桶的预定直径的至少50％ 超音速自由射流膨胀的冲击。 向至少一个离子导向器提供RF电压。 径向气体导电在至少一个离子导向器的第一部分中减小，用于阻尼由超音速自由射流膨胀产生的冲击波。

    COLLISION ION GENERATOR AND SEPARATOR
    6.
    发明申请
    COLLISION ION GENERATOR AND SEPARATOR 审中-公开
    碰撞离子发生器和分离器

    公开(公告)号：WO2013098642A2

    公开(公告)日：2013-07-04

    申请号：PCT/IB2012002995

    申请日：2012-12-28

    申请人： MEDIMASS LTD

    发明人： SZALAY DANIEL ,  GODORHAZY LAJOS ,  TAKATS ZOLTAN

    CPC分类号： H01J49/142 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/0454 ,  H01J49/14 ,  H01J49/16

    摘要： According to some embodiments, systems and methods for surface impact ionization of liquid phase and aerosol samples are provided. The method includes accelerating a liquid or aerosol sample, colliding the sample with a solid collision surface thereby disintegrating the sample into both molecular ionic species (e.g., gaseous molecular ions) and molecular neutral species (e.g., gaseous sample), and transporting the disintegrated sample to an ion analyzer. Some embodiments of the method further comprise discarding the molecular neutral species. Such embodiments transport substantially only the molecular ionic species to the ion analyzer.

    摘要翻译： 根据一些实施例，提供了液相和气溶胶样品的表面碰撞电离的系统和方法。 该方法包括加速液体或气溶胶样品，将样品与固体碰撞表面碰撞，从而将样品分解成分子离子物质（例如气态分子离子）和分子中性物质（例如气态样品），并将分解的样品 到离子分析仪。 该方法的一些实施方案还包括丢弃分子中性物种。 这样的实施例基本上只将分子离子物质转移到离子分析器。

    SAMPLE TRANSFERRING APPARATUS FOR MASS CYTOMETRY
    7.
    发明申请
    SAMPLE TRANSFERRING APPARATUS FOR MASS CYTOMETRY 审中-公开
    样品传送装置用于大规模细胞计数

    公开(公告)号：WO2013061155A1

    公开(公告)日：2013-05-02

    申请号：PCT/IB2012/002568

    申请日：2012-10-26

    申请人： DVS SCIENCES INC.

    发明人： JONG, Raymond

    IPC分类号： G01N15/10 ,  C12M1/34 ,  H01J49/04

    CPC分类号： H01J49/0445 ,  G01N15/06 ,  G01N15/10 ,  G01N35/10 ,  G01N2015/0065 ,  G01N2015/1006 ,  H01J49/045 ,  H01J49/105

    摘要： In a mass cytometer or mass spectrometer, a sample of elemental tagged particles is transferred from a dispersion to a gas flow through a carrier aerosol spray for atomization and ionization by inductively coupled plasma (ICP) source. The configuration of the sample transfer apparatus allow for total consumption of the sample by passing the sample spray through a deceleration stage to decelerate the spray of particles from its high velocity expansion. Following the deceleration stage, the decelerated sample of particles can be accelerated and focused through an acceleration stage for transferring into the ICP. This effectively improves the particle transfer between the sample spray and the ICP.

    摘要翻译： 在质谱仪或质谱仪中，将元素标记的颗粒的样品从分散体转移到通过载体气溶胶喷雾的气流中，以通过电感耦合等离子体（ICP）源进行雾化和电离。 样品转印装置的结构允许通过使样品喷雾通过减速阶段来使样品总消耗，以使颗粒从其高速膨胀中的喷雾减速。 在减速阶段后，减速的颗粒样品可以通过加速阶段加速和聚焦，以转移到ICP中。 这有效地改善了样品喷雾和ICP之间的颗粒转移。

    HIGH SENSITIVITY MASS SPECTROMETRY SYSTEMS
    8.
    发明申请
    HIGH SENSITIVITY MASS SPECTROMETRY SYSTEMS 审中-公开
    高灵敏度的质谱系统

    公开(公告)号：WO2012155090A3

    公开(公告)日：2013-01-17

    申请号：PCT/US2012037617

    申请日：2012-05-11

    申请人： UNIV ILLINOIS STATE ,  MULLIGAN CHRISTOPHER C

    发明人： MULLIGAN CHRISTOPHER C

    IPC分类号： H01J49/26 ,  G01N27/62

    CPC分类号： H01J49/167 ,  H01J49/0445 ,  H01J49/0468

    摘要： A high sensitivity desorption electrospray ionization mass spectrometry system that employs a heated platform, along with means for directing a liquid stream containing an analyte of interest onto a target location on the heated platform to heat the stream, an electrospray emitter for generating an electrospray and directing the electrospray at the target location on the heated platform to produce an ionized, desorbed analyte, and a mass spectrometer for receiving and detecting the ionized, desorbed analyte.

    摘要翻译： 采用加热平台的高灵敏度解吸电喷雾电离质谱系统，以及用于将含有感兴趣分析物的液体流引导到加热平台上的目标位置以加热流的装置，用于产生电喷雾和引导的电喷射发射器 在加热的平台上的目标位置处的电喷雾以产生离子化的解吸附的分析物，以及用于接收和检测电离的解吸附的分析物的质谱仪。

    AEROSOL MASS SPECTROMETRY SYSTEMS AND METHODS
    10.
    发明申请
    AEROSOL MASS SPECTROMETRY SYSTEMS AND METHODS 审中-公开
    AEROSOL质谱系统和方法

    公开(公告)号：WO2009097064A2

    公开(公告)日：2009-08-06

    申请号：PCT/US2008087624

    申请日：2008-12-19

    申请人： L LIVERMORE NAT SECURITY LLC ,  FERGENSON DAVID P ,  GARD ERIC E

    发明人： FERGENSON DAVID P ,  GARD ERIC E

    IPC分类号： H01J49/04

    CPC分类号： H01J49/40 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/164

    摘要： A system according to one embodiment includes a particle accelerator that directs a succession of polydisperse aerosol particles along a predetermined particle path; multiple tracking lasers for generating beams of light across the particle path; an optical detector positioned adjacent the particle path for detecting impingement of the beams of light on individual particles; a desorption laser for generating a beam of desorbing light across the particle path about coaxial with a beam of light produced by one of the tracking lasers; and a controller, responsive to detection of a signal produced by the optical detector, that controls the desorption laser to generate the beam of desorbing fight. Additional systems and methods are also disclosed.

    摘要翻译： 根据一个实施方案的系统包括颗粒促进剂，其引导一系列多分散气溶胶颗粒沿着预定的颗粒路径; 用于在颗粒路径上产生光束的多个跟踪激光器; 位于颗粒路径附近的光学检测器，用于检测单个颗粒上的光束的撞击; 解吸激光器，用于产生与所述跟踪激光器之一产生的光束同轴的所述粒子路径上的解吸光束; 以及响应于检测由光学检测器产生的信号的控制器，其控制解吸激光器以产生解吸束的战斗。 还公开了附加的系统和方法。