公开(公告)号：WO2022223977A1

公开(公告)日：2022-10-27

申请号：PCT/GB2022/051008

申请日：2022-04-21

Applicant: MICROMASS UK LIMITED

Inventor： TRIVETT, Ian ,  WALFORD, Mark ,  KENNY, Daniel James ,  BAJIC, Stevan ,  MATHAI, Suloke

IPC: H01J49/16 ,  H01J49/04

Abstract: A nebuliser outlet (20) comprises one or more first channels (24), wherein the nebuliser outlet (20) is configured such that liquid received by the nebuliser outlet (20) can pass to one or more nebulisation regions via the one or more first channels (24), and one or more second channels (25), wherein the nebuliser outlet (20) is configured such that gas received by the nebuliser outlet (20) can pass to the one or more nebulisation regions via the one or more second channels (25). The one or more first channels (24) comprise a first portion (24a) and a second portion (24b), wherein the first portion (24a) comprises a tubular channel, and wherein the second portion (24b) comprises multiple channels, an annular channel, or a segmented annular channel. The one or more second channels (25) converge with the second portion (24b) at the one or more nebulisation regions.

公开(公告)号：WO2020084296A1

公开(公告)日：2020-04-30

申请号：PCT/GB2019/053008

申请日：2019-10-22

Applicant: MICROMASS UK LIMITED

Inventor： GORDON, David ,  KENNY, Daniel James ,  MOULDS, Richard Barrington ,  LANGRIDGE, David J.

IPC: H01J49/00 ,  H01J49/02

Abstract: A dual-mode ion detector for a mass and/or ion mobility spectrometer comprising a first conversion electrode (20) that is maintained, in use, at a negative potential and arranged for converting incident positive ions (32) into secondary electrons (34), and a second conversion electrode (22) that is maintained, in use, at a positive potential and arranged for converting incident negative ions (42) into secondary positive ions (44) and/or secondary electrons (74). The detector also comprises an electron detecting surface (26) and an entrance electrode (24) for drawing ions into the ion detector. The ion detector is switchable between a first mode for detecting positive ions and a second mode for detecting negative ions.

公开(公告)号：WO2013005058A1

公开(公告)日：2013-01-10

申请号：PCT/GB2012/051607

申请日：2012-07-06

Applicant: MICROMASS UK LIMITED ,  WILDGOOSE, Jason Lee ,  PRINGLE, Steven Derek ,  GILES, Kevin ,  BROWN, Jeffery Mark ,  MURRAY, Paul ,  KENNY, Daniel James

Inventor： WILDGOOSE, Jason Lee ,  PRINGLE, Steven Derek ,  GILES, Kevin ,  BROWN, Jeffery Mark ,  MURRAY, Paul ,  KENNY, Daniel James

IPC: H01J49/06

CPC classification number: H01J49/10 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/065 ,  H01J49/161

Abstract: A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.

Abstract translation: 公开了脉冲离子源，其中离子源被激发一次或多次以产生第一组离子和第二组离子。 第一和第二组离子同时透过离子导向器同时保持第一和第二组离子彼此隔离。

公开(公告)号：WO2015040391A1

公开(公告)日：2015-03-26

申请号：PCT/GB2014/052825

申请日：2014-09-17

Applicant: MICROMASS UK LIMITED

Inventor： GORDON, David ,  KENNY, Daniel James ,  MOULDS, Richard Barrington

IPC: H01J49/04 ,  G01F1/68

CPC classification number: H01J49/025 ,  G01F1/68 ,  H01J49/0027 ,  H01J49/0422 ,  H01J49/10

Abstract: Apparatus for a mass spectrometer is disclosed comprising an ion source, a heater (230) for heating a gas flow (224) to the ion source, a temperature sensor for monitoring the temperature of the heater (230), and a control system (236). The control system (236) is arranged and adapted to determine a flow rate of the gas flow (224) by monitoring the power supplied to the heater (230) and the temperature of the heater (230).

Abstract translation: 公开了一种用于质谱仪的装置，包括离子源，用于加热到离子源的气流（224）的加热器（230），用于监测加热器（230）的温度的温度传感器，以及控制系统（236） ）。 控制系统（236）被布置和适于通过监视供应给加热器（230）的功率和加热器（230）的温度来确定气流（224）的流量。

公开(公告)号：WO2015040385A1

公开(公告)日：2015-03-26

申请号：PCT/GB2014/052817

申请日：2014-09-17

Applicant: MICROMASS UK LIMITED

Inventor： GORDON, David ,  KENNY, Daniel James ,  MOULDS, Richard Barrington

IPC: H01J49/00 ,  H01J49/06

CPC classification number: H01J49/24 ,  F04B2205/112 ,  F04C28/00 ,  F04C28/02 ,  G01L19/08 ,  G01N27/622 ,  H01J49/0013 ,  H01J49/067

Abstract: A mass spectrometer or ion mobility spectrometer is disclosed comprising means for detecting a blockage in an inlet orifice (6) arranged between an ion source and a vacuum chamber (2). The blockage is detected as a result of a reduction in pressure within the vacuum chamber (2). This change in pressure is detected indirectly by monitoring the amount of power that a vacuum pump (10) is using, the amount of current that a vacuum pump (10) is drawing, the temperature of a vacuum pump (10) or a region in proximity to the vacuum pump (10), or the flow rate of gas out of a vacuum pump (10).

Abstract translation: 公开了一种质谱仪或离子迁移谱仪，其包括用于检测在离子源和真空室（2）之间布置的入口孔（6）中的堵塞的装置。 作为真空室（2）内的压力降低的结果，检测到堵塞物。 通过监视真空泵（10）正在使用的功率量，真空泵（10）正在抽出的电流量，真空泵（10）的温度或者在 靠近真空泵（10）或从真空泵（10）排出的气体的流量。

公开(公告)号：WO2014191750A1

公开(公告)日：2014-12-04

申请号：PCT/GB2014/051643

申请日：2014-05-29

Applicant: MICROMASS UK LIMITED

Inventor： GORDON, David ,  KENNY, Daniel James

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/24

CPC classification number: H01J49/0013 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/10 ,  H01J49/145 ,  H01J49/24 ,  H01J49/40

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source (701) and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector (705) is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide (703) is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector (705) is ≤ 400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyser,a 3D ion trap mass analyser, a 2D or linear ion trap mass analyser, a Time of Flight mass analyser, a quadrupole-Time of Flight mass analyser or an electrostatic mass analyser arranged in the third vacuum chamber. The product of the pressure P 1 in the vicinity of the first RF ion guide and the length L 1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P 2 in the vicinity of the second RF ion guide (703) and the length L 2 of the second RF ion guide (703) is in the range 0.05-0.3 mbar-cm.

Abstract translation: 公开了一种微型质谱仪，其包括大气压电离源（701）和具有大气压采样孔或毛细管的第一真空室，位于第一真空室下游的第二真空室和位于第二真空室下游的第三真空室 真空室。 离子检测器（705）位于第三真空室中。 第一RF离子引导件位于第一真空室内，第二RF离子导向器（703）位于第二真空室内。 从大气压采样孔或毛细管到离子检测器（705）的离子检测表面的离子路径长度≤400mm。 质谱仪还包括串联四极杆质谱仪，3D离子阱质谱仪，2D或线性离子阱质谱仪，飞行时间质量分析仪，四极杆飞行时间质量分析仪或静电质量分析仪 第三真空室。 第一RF离子导向器附近的压力P1与第一RF离子导向件的长度L1的乘积在10-100mbar-cm的范围内，第二RF离子附近的压力P2的乘积 引导件（703）和第二RF离子引导件（703）的长度L2在0.05-0.3mbar-cm的范围内。

公开(公告)号：WO2014191747A1

公开(公告)日：2014-12-04

申请号：PCT/GB2014/051640

申请日：2014-05-29

Applicant: MICROMASS UK LIMITED

Inventor： GORDON, David ,  KENNY, Daniel James

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/24

CPC classification number: H01J49/0013 ,  H01J49/062 ,  H01J49/10 ,  H01J49/24

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source (701), a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector (705) is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide (703) is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector (705) is ≤ 400 mm. The product of the pressure P 1 in the vicinity of the first RF ion guide and the length L 1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P 2 in the vicinity of the second RF ion guide (703) and the length L 2 of the second RF ion guide (703) is in the range 0.05-0.3 mbar-cm.

Abstract translation: 公开了一种微型质谱仪，其包括大气压电离源（701），具有大气压采样孔或毛细管的第一真空室，位于第一真空室下游的第二真空室和位于第二真空室下游的第三真空室 真空室。 离子检测器（705）位于第三真空室中。 第一RF离子引导件位于第一真空室内，第二RF离子导向器（703）位于第二真空室内。 从大气压采样孔或毛细管到离子检测器（705）的离子检测表面的离子路径长度≤400mm。 第一RF离子导向器附近的压力P1与第一RF离子导向件的长度L1的乘积在10-100mbar-cm的范围内，第二RF离子附近的压力P2的乘积 引导件（703）和第二RF离子引导件（703）的长度L2在0.05-0.3mbar-cm的范围内。

公开(公告)号：WO2013038211A1

公开(公告)日：2013-03-21

申请号：PCT/GB2012/052292

申请日：2012-09-17

Applicant: MICROMASS UK LIMITED

Inventor： LANGRIDGE, David J. ,  KENNY, Daniel James

IPC: H01J49/06 ,  H01J49/42

CPC classification number: H01J49/4215 ,  H01J49/0027 ,  H01J49/06 ,  H01J49/063 ,  H01J49/36 ,  H01J49/422 ,  H01J49/4225

Abstract: A RF only quadrupole rod set mass filter or mass analyser and a linear quadrupole ion trap with axial ejection are disclosed comprising a first pair of rod electrodes, a second pair of rod electrodes and an energy filter. The first pair of rod electrodes is longer than the second pair of rod electrodes. Ions having desired mass to charge ratios experience fringing fields at an exit region which results in the ions possessing sufficient axial kinetic energy to be transmitted by the energy filter. Other ions possess insufficient axial kinetic energy to be transmitted by the energy filter and are attenuated.

Abstract translation: 公开了一种射频唯一四极杆组质量过滤器或质量分析器和具有轴向喷射的线性四极离子阱，其包括第一对杆电极，第二对棒电极和能量过滤器。 第一对杆电极比第二对杆电极长。 具有期望的质荷比的离子在出口区域处经历边缘场，这导致离子具有足够的轴向动能以被能量过滤器传输。 其他离子具有不足的轴向动能，由能量过滤器传递并被衰减。

公开(公告)号：WO2013027055A1

公开(公告)日：2013-02-28

申请号：PCT/GB2012/052054

申请日：2012-08-22

Applicant: MICROMASS UK LIMITED ,  GILES, Kevin ,  GREEN, Martin Raymond ,  KENNY, Daniel James ,  LANGRIDGE, David J. ,  WILDGOOSE, Jason Lee

Inventor： GILES, Kevin ,  GREEN, Martin Raymond ,  KENNY, Daniel James ,  LANGRIDGE, David J. ,  WILDGOOSE, Jason Lee

IPC: H01J49/42

CPC classification number: H01J49/4285 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/063 ,  H01J49/40 ,  H01J49/422

Abstract: A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. The profile of the quadratic DC potential well progressively varies along the second (x) direction.

Abstract translation: 公开了将离子引导到小的喷射区域中的质量或质量比选择性离子阱。 RF电压用于将离子限制在离子阱内的第一（y）方向。 DC或RF电压用于将离子限制在第二（x）方向。 二次直流势阱用于将离子限制在离子阱内的第三（z）方向。 二次直流电势的曲线沿着第二（x）方向逐渐变化。

公开(公告)号：WO2012164309A2

公开(公告)日：2012-12-06

申请号：PCT/GB2012/051254

申请日：2012-06-01

Applicant: MICROMASS UK LIMITED ,  KENNY, Daniel James

Inventor： KENNY, Daniel James

IPC: H01J49/06

CPC classification number: H01J49/0495 ,  H01J49/0418 ,  H01J49/062 ,  H01J49/067 ,  H01J49/24

Abstract: A mass spectrometer is disclosed comprising two vacuum chambers maintained at different pressures. The two vacuum chambers are interconnected by a differential pumping aperture (5a). The effective area of the opening (5a) between the two vacuum chambers may be varied by rotating a disk (7) having an aperture (7) a in front of the differential pumping aperture (5a) so as to vary the gas flow rate through the opening (5a) and between the two chambers.

Abstract translation: 公开了一种质谱仪，其包括保持在不同压力下的两个真空室。 两个真空室通过差动泵浦孔（5a）相互连接。 两个真空室之间的开口（5a）的有效面积可以通过在差动泵送孔（5a）的前面旋转具有孔（7）a的盘（7）来改变气体流速通过 开口（5a）和两个室之间。