公开(公告)号：WO2019158931A1

公开(公告)日：2019-08-22

申请号：PCT/GB2019/050405

申请日：2019-02-15

Applicant: MICROMASS UK LIMITED

Inventor： GREEN, Martin Raymond ,  GORDON, David ,  LANGRIDGE, David

IPC: H01J49/42

Abstract: A method of operating a quadrupole device is disclosed. The method comprises applying a main drive voltage to the quadrupole device and applying three or more auxiliary drive voltages to the quadrupole device. The three or more auxiliary drive voltages correspond to two or more pairs of X-band or Y-band auxiliary drive voltages.

公开(公告)号：WO2015189548A1

公开(公告)日：2015-12-17

申请号：PCT/GB2015/000176

申请日：2015-06-12

Applicant: MICROMASS UK LIMITED

Inventor： BROWN, Jeffery Mark ,  GORDON, David ,  KENNY, Daniel James ,  MURRAY, Paul

IPC: H01J49/14 ,  H01J49/16

CPC classification number: H01J49/165 ,  G01N27/622 ,  H01J49/0031 ,  H01J49/145 ,  H01J49/24

Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing gas phase analyte (2) in a vacuum housing (5); electrospraying a reagent solution outside of the vacuum housing so as to form charged droplets of reagent solution and/or reagent ions (4); conveying the charged droplets and/or reagent ions (4) into the vacuum housing and reacting them with the analyte so as to form analyte ions; and analysing the analyte ions with a mass analyser and/or ion mobility analyser (6). Reacting the droplets of reagent solution and/or reagent ions with the analyte in sub-atmospheric pressures improved the reaction conditions.

Abstract translation: 公开了一种质谱法或离子迁移光谱法，其包括：在真空壳体（5）中提供气相分析物（2）; 在真空壳体外部电喷雾试剂溶液，以形成试剂溶液和/或试剂离子（4）的带电液滴; 将带电的液滴和/或试剂离子（4）输送到真空壳体中并使其与分析物反应以形成分析物离子; 并用质量分析器和/或离子迁移率分析仪（6）分析分析物离子。 使试剂溶液和/或试剂离子与分析物在低于大气压的压力下反应提高了反应条件。

公开(公告)号：WO2010136780A1

公开(公告)日：2010-12-02

申请号：PCT/GB2010/001077

申请日：2010-05-28

Applicant: MICROMASS UK LIMITED ,  HUGHES, Christopher, John ,  MCKENNA, Thérèse ,  GORDON, David ,  KENNY, Daniel, James

Inventor： HUGHES, Christopher, John ,  MCKENNA, Thérèse ,  GORDON, David ,  KENNY, Daniel, James

IPC: G01N33/68 ,  H01J49/00

CPC classification number: G01N33/6848 ,  H01J49/0031 ,  H01J49/0045 ,  Y10T436/24

Abstract: A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan (1) is performed. A negative ion high resolution MS scan (4) is then performed and then MRM channels in positive ion mode are determined and monitored (5). A positive ion MS/MS scan is then performed.

Abstract translation: 公开了一种检测和测序翻译后修饰的肽的方法，其中进行负离子前体扫描（1）。 然后执行负离子高分辨率MS扫描（4），然后确定和监测正离子模式中的MRM通道（5）。 然后进行正离子MS / MS扫描。

公开(公告)号：WO2020084296A1

公开(公告)日：2020-04-30

申请号：PCT/GB2019/053008

申请日：2019-10-22

Applicant: MICROMASS UK LIMITED

Inventor： GORDON, David ,  KENNY, Daniel James ,  MOULDS, Richard Barrington ,  LANGRIDGE, David J.

IPC: H01J49/00 ,  H01J49/02

Abstract: A dual-mode ion detector for a mass and/or ion mobility spectrometer comprising a first conversion electrode (20) that is maintained, in use, at a negative potential and arranged for converting incident positive ions (32) into secondary electrons (34), and a second conversion electrode (22) that is maintained, in use, at a positive potential and arranged for converting incident negative ions (42) into secondary positive ions (44) and/or secondary electrons (74). The detector also comprises an electron detecting surface (26) and an entrance electrode (24) for drawing ions into the ion detector. The ion detector is switchable between a first mode for detecting positive ions and a second mode for detecting negative ions.

公开(公告)号：WO2014064400A1

公开(公告)日：2014-05-01

申请号：PCT/GB2012/052653

申请日：2012-10-25

Applicant: MICROMASS UK LIMITED

Inventor： GORDON, David ,  BAJIC, Stevan

IPC: H01J49/04 ,  H01J49/16

CPC classification number: H01J49/16 ,  H01J49/0431 ,  H01J49/0445 ,  H01J49/26

Abstract: An ion source is disclosed comprising one or more nebulisers and one or more mesh or grid targets (20). The one or more nebulisers are arranged and adapted to emit, in use, a stream predominantly of droplets which are caused to impact upon the one or more mesh or grid targets (20) and to ionise the droplets to form a plurality of ions.

Abstract translation: 公开了一种离子源，其包括一个或多个雾化器和一个或多个网格或网格目标（20）。 一个或多个雾化器被布置和适于在使用中发射主要是液滴的流，所述液滴被引起撞击到一个或多个网格或网格目标（20）上，并且使液滴离子以形成多个离子。

公开(公告)号：WO2022043695A1

公开(公告)日：2022-03-03

申请号：PCT/GB2021/052222

申请日：2021-08-26

Applicant: MICROMASS UK LIMITED

Inventor： GORDON, David ,  LUMLEY, Nicola ,  BOOTH, Alastair ,  MOULDS, Richard

IPC: H01J49/00

Abstract: A mass spectrometer is disclosed comprising: an ion detector; ion optics for guiding ions to the ion detector; one or more voltage supply for supplying voltages to said ion optics; control circuitry for controlling the one or more voltage supply so as to switch the ion optics between operating in a first mode in which the ion optics are unable to transmit ions having a first mass to charge ratio or first polarity to the ion detector and a second mode in which the ion optics are able to transmit ions having said first mass to charge ratio or first polarity to the ion detector for a time period; and to repeatedly switch between the first and second modes a plurality of times; and a processor and circuitry configured to: (i) determine the intensity of an ion signal detected by the detector at a first time in each of the time periods that the ion optics are in the second mode; and (ii) determine the intensity of the ion signal detected by the detector at a second, later time in each of the time periods that the ion optics are in the second mode.

公开(公告)号：WO2017194974A1

公开(公告)日：2017-11-16

申请号：PCT/GB2017/051348

申请日：2017-05-15

Applicant: MICROMASS UK LIMITED

Inventor： SLATER, Stephen Patrick ,  IVESON, John ,  MALPAS, Oliver John ,  CHANDE, Bharat ,  GORDON, David

IPC: H01J49/06

Abstract: Disclosed herein is an ion guide comprising a plurality of axially stacked plates, wherein at least some or all of said plates comprise: a first electrically conductive portion; and a second electrically conductive portion, wherein the second electrically conductive portion is electrically isolated from the first electrically conductive portion, the first and second electrically conductive portions being shaped and arranged relative to each other so as to define an opening through which ions are axially transmitted in use; wherein, in use, a first AC or RF voltage is applied to the first electrically conductive portion and a second AC or RF voltage is applied to the second electrically conductive portion in order to confine ions radially within said opening. The first and second electrically conductive portions (1, 2) may be separately formed and interleaved within the ion guide to define the plates. Alternatively the first (41, 43) and second (42, 44) electrically conductive portions may be printed onto a common substrate (4).

Abstract translation: 本文公开了一种离子引导件，其包括多个轴向堆叠的板，其中至少一些或所有所述板包括：第一导电部分; 以及第二导电部分，其中所述第二导电部分与所述第一导电部分电隔离，所述第一导电部分和所述第二导电部分相对于彼此成形并且布置以限定离子沿轴向传输通过的开口 正在使用; 其中在使用中，将第一AC或RF电压施加到所述第一导电部分，并将第二AC或RF电压施加到所述第二导电部分，以便将离子径向限制在所述开口内。 第一导电部分和第二导电部分（1,2）可以分别形成并交错在离子导向器内以限定板。 可选地，第一导电部分（41,43）和第二导电部分（42,44）可以被印刷到公共衬底（4）上。

公开(公告)号：WO2015040391A1

公开(公告)日：2015-03-26

申请号：PCT/GB2014/052825

申请日：2014-09-17

Applicant: MICROMASS UK LIMITED

Inventor： GORDON, David ,  KENNY, Daniel James ,  MOULDS, Richard Barrington

IPC: H01J49/04 ,  G01F1/68

CPC classification number: H01J49/025 ,  G01F1/68 ,  H01J49/0027 ,  H01J49/0422 ,  H01J49/10

Abstract: Apparatus for a mass spectrometer is disclosed comprising an ion source, a heater (230) for heating a gas flow (224) to the ion source, a temperature sensor for monitoring the temperature of the heater (230), and a control system (236). The control system (236) is arranged and adapted to determine a flow rate of the gas flow (224) by monitoring the power supplied to the heater (230) and the temperature of the heater (230).

Abstract translation: 公开了一种用于质谱仪的装置，包括离子源，用于加热到离子源的气流（224）的加热器（230），用于监测加热器（230）的温度的温度传感器，以及控制系统（236） ）。 控制系统（236）被布置和适于通过监视供应给加热器（230）的功率和加热器（230）的温度来确定气流（224）的流量。

公开(公告)号：WO2015040385A1

公开(公告)日：2015-03-26

申请号：PCT/GB2014/052817

申请日：2014-09-17

Applicant: MICROMASS UK LIMITED

Inventor： GORDON, David ,  KENNY, Daniel James ,  MOULDS, Richard Barrington

IPC: H01J49/00 ,  H01J49/06

CPC classification number: H01J49/24 ,  F04B2205/112 ,  F04C28/00 ,  F04C28/02 ,  G01L19/08 ,  G01N27/622 ,  H01J49/0013 ,  H01J49/067

Abstract: A mass spectrometer or ion mobility spectrometer is disclosed comprising means for detecting a blockage in an inlet orifice (6) arranged between an ion source and a vacuum chamber (2). The blockage is detected as a result of a reduction in pressure within the vacuum chamber (2). This change in pressure is detected indirectly by monitoring the amount of power that a vacuum pump (10) is using, the amount of current that a vacuum pump (10) is drawing, the temperature of a vacuum pump (10) or a region in proximity to the vacuum pump (10), or the flow rate of gas out of a vacuum pump (10).

Abstract translation: 公开了一种质谱仪或离子迁移谱仪，其包括用于检测在离子源和真空室（2）之间布置的入口孔（6）中的堵塞的装置。 作为真空室（2）内的压力降低的结果，检测到堵塞物。 通过监视真空泵（10）正在使用的功率量，真空泵（10）正在抽出的电流量，真空泵（10）的温度或者在 靠近真空泵（10）或从真空泵（10）排出的气体的流量。

公开(公告)号：WO2014191750A1

公开(公告)日：2014-12-04

申请号：PCT/GB2014/051643

申请日：2014-05-29

Applicant: MICROMASS UK LIMITED

Inventor： GORDON, David ,  KENNY, Daniel James

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/24

CPC classification number: H01J49/0013 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/10 ,  H01J49/145 ,  H01J49/24 ,  H01J49/40

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source (701) and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector (705) is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide (703) is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector (705) is ≤ 400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyser,a 3D ion trap mass analyser, a 2D or linear ion trap mass analyser, a Time of Flight mass analyser, a quadrupole-Time of Flight mass analyser or an electrostatic mass analyser arranged in the third vacuum chamber. The product of the pressure P 1 in the vicinity of the first RF ion guide and the length L 1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P 2 in the vicinity of the second RF ion guide (703) and the length L 2 of the second RF ion guide (703) is in the range 0.05-0.3 mbar-cm.

Abstract translation: 公开了一种微型质谱仪，其包括大气压电离源（701）和具有大气压采样孔或毛细管的第一真空室，位于第一真空室下游的第二真空室和位于第二真空室下游的第三真空室 真空室。 离子检测器（705）位于第三真空室中。 第一RF离子引导件位于第一真空室内，第二RF离子导向器（703）位于第二真空室内。 从大气压采样孔或毛细管到离子检测器（705）的离子检测表面的离子路径长度≤400mm。 质谱仪还包括串联四极杆质谱仪，3D离子阱质谱仪，2D或线性离子阱质谱仪，飞行时间质量分析仪，四极杆飞行时间质量分析仪或静电质量分析仪 第三真空室。 第一RF离子导向器附近的压力P1与第一RF离子导向件的长度L1的乘积在10-100mbar-cm的范围内，第二RF离子附近的压力P2的乘积 引导件（703）和第二RF离子引导件（703）的长度L2在0.05-0.3mbar-cm的范围内。