公开(公告)号：WO2016116585A1

公开(公告)日：2016-07-28

申请号：PCT/EP2016/051287

申请日：2016-01-22

Applicant: NESTEC S.A.

Inventor： FAURE, Magali ,  BLUM-SPERISEN, Stéphanie ,  BOSCO, Mohamed Nabil ,  BRAHMBHATT, Viral ,  BREUILLE, Denis

IPC: A61K31/198 ,  A61P29/00 ,  A61P19/00

CPC classification number: A61K31/401 ,  A23L33/175 ,  A23V2002/00 ,  A61K31/198

Abstract: Methods and compositions are provided that use proline, serine and threonine to promote healing of the intestinal mucosa. A therapeutically effective amount of proline, serine and threonine is administered to an individual in need thereof, for example a human or other mammal, such as an individual that has damaged intestinal mucosa. The methods and compositions can promote mucosal healing, restore gut barrier function, repair intestinal epithelial cells, promote protection of the colonic epithelium, and/or promote the replenishment of goblet cells in the intestinal and colonic mucosa.

Abstract translation: 提供了使用脯氨酸，丝氨酸和苏氨酸促进肠粘膜愈合的方法和组合物。 向有需要的个体施用治疗有效量的脯氨酸，丝氨酸和苏氨酸，例如人或其它哺乳动物，例如具有损伤的肠粘膜的个体。 方法和组合物可以促进粘膜愈合，恢复肠屏障功能，修复肠上皮细胞，促进结肠上皮的保护和/或促进肠和结肠粘膜中杯状细胞的补充。

公开(公告)号：WO2016116582A1

公开(公告)日：2016-07-28

申请号：PCT/EP2016/051279

申请日：2016-01-22

Applicant: NESTEC S.A.

Inventor： FAURE, Magali ,  BLUM-SPERISEN, Stéphanie ,  BOSCO, Mohamed Nabil ,  BRAHMBHATT, Viral ,  BREUILLE, Denis

IPC: A61K31/198 ,  A61P29/00 ,  A61P19/02

CPC classification number: A61K31/198 ,  A61K45/06 ,  Y02A50/465

Abstract: Methods and compositions are provided that treat or prevent inflammation using serine. A therapeutically effective amount of serine is administered to an individual, for example a human or other mammal, that has inflammation or is at risk of inflammation. The methods and compositions can control and/or alleviate an inflammatory reaction of the body, such as colitis.

Abstract translation: 提供了使用丝氨酸治疗或预防炎症的方法和组合物。 对具有炎症或有炎症风险的个体，例如人或其他哺乳动物施用治疗有效量的丝氨酸。 方法和组合物可以控制和/或减轻身体的炎症反应，如结肠炎。

公开(公告)号：WO2014020004A1

公开(公告)日：2014-02-06

申请号：PCT/EP2013/065948

申请日：2013-07-30

Applicant: NESTEC S.A.

Inventor： SCHIFFRIN, Eduardo ,  BRAHMBHATT, Viral ,  MARTIN, François-Pierre ,  BENYACOUB, Jalil

IPC: A23L1/29 ,  A23L1/30 ,  A23L1/302 ,  A23L1/304 ,  A23L1/305

CPC classification number: A61K31/122 ,  A23L2/38 ,  A23L2/66 ,  A23L5/40 ,  A23L33/10 ,  A23L33/12 ,  A23L33/135 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/175 ,  A23L33/19 ,  A23L33/21 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A61K31/015 ,  A61K31/07 ,  A61K31/14 ,  A61K31/197 ,  A61K31/20 ,  A61K31/202 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/59 ,  A61K31/714 ,  A61K33/00 ,  A61K33/04 ,  A61K33/06 ,  A61K33/16 ,  A61K33/18 ,  A61K33/20 ,  A61K33/24 ,  A61K33/26 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K33/42 ,  A61K38/1709 ,  A61K45/06 ,  A23V2200/32 ,  A23V2250/1578 ,  A23V2250/1582 ,  A23V2250/1586 ,  A23V2250/1588 ,  A23V2250/159 ,  A23V2250/1592 ,  A23V2250/1598 ,  A23V2250/16 ,  A23V2250/1608 ,  A23V2250/161 ,  A23V2250/1612 ,  A23V2250/1614 ,  A23V2250/1618 ,  A23V2250/1626 ,  A23V2250/1642 ,  A23V2250/1872 ,  A23V2250/1874 ,  A23V2250/1878 ,  A23V2250/1882 ,  A23V2250/54246 ,  A23V2250/702 ,  A23V2250/7042 ,  A23V2250/7044 ,  A23V2250/7046 ,  A23V2250/705 ,  A23V2250/7052 ,  A23V2250/7056 ,  A23V2250/708 ,  A23V2250/71 ,  A23V2250/712 ,  A23V2250/7142 ,  A23V2250/7144 ,  A23V2250/72

Abstract: A nutritional composition for promoting musculoskeletal health in patients with inflammatory bowel disease is disclosed. The nutritional composition comprises casein protein, vitamin K in a ratio of vitamin K1:vitamin K2 being between 3:1 to 1:3 and the vitamin K providing between 3.5-20 µg/100kcal of the nutritional composition, vitamin D and alpha-linolenic acid. A pharmaceutical formulation, a nutritional formulation, a tube-feed formulation, a dietary supplement, a functional food, a beverage product or a combination thereof comprising the nutritional composition is also disclosed. A method for improving musculoskeletal health is also disclosed.

Abstract translation: 公开了一种用于促进炎症性肠病患者肌肉骨骼健康的营养组合物。 营养成分包含酪蛋白，维生素K比例维生素K 3：维生素K2在3:1至1:3之间，维生素K提供3.5-20μg/ 100kcal营养组合物，维生素D和α-亚麻酸之间的维生素K 酸。 还公开了包含营养组合物的药物制剂，营养制剂，管饲料制剂，膳食补充剂，功能食品，饮料产品或其组合。 还公开了一种用于改善肌肉骨骼健康的方法。

公开(公告)号：WO2013000895A9

公开(公告)日：2013-01-03

申请号：PCT/EP2012/062326

申请日：2012-06-26

Applicant: NESTEC S.A. ,  BOSCO, Mohamed Nabil ,  OLIVEIRA, Manuel ,  DESTAILLATS, Frederic ,  BENYACOUB, Jalil ,  BRAHMBHATT, Viral

Inventor： BOSCO, Mohamed Nabil ,  OLIVEIRA, Manuel ,  DESTAILLATS, Frederic ,  BENYACOUB, Jalil ,  BRAHMBHATT, Viral

IPC: A61K31/202 ,  A61K47/44 ,  A23G1/36 ,  A61P27/02 ,  A61P17/00 ,  A61P9/10 ,  A61P25/00 ,  A61P9/12 ,  A61P1/00 ,  A61P3/00

Abstract: The present invention generally relates to the prevention or treatment of disorders related to oxidative stress. For example, the present invention provides a composition for use in the prevention or treatment of oxidative stress related disorders under post-operative conditions. One embodiment of the present invention is a composition comprising DHA and EPA as active ingredients for use in the treatment or prevention of oxidative stress and/or related disorders.

公开(公告)号：WO2016116584A1

公开(公告)日：2016-07-28

申请号：PCT/EP2016/051286

申请日：2016-01-22

Applicant: NESTEC S.A.

Inventor： SCHIFFRIN, Eduardo ,  BRAHMBHATT, Viral ,  MARTIN, François-Pierre ,  MONTOLIU ROURA, Ivan ,  REZZI, Serge André Dominique ,  BENYACOUB, Jalil

IPC: G01N33/68

CPC classification number: G01N33/92 ,  G01N33/53 ,  G01N33/6893 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2800/065 ,  G01N2800/54

Abstract: The invention relates to a method, a system and kit for identifying the sample of a patient having IBD or predicting the relapse of IBD in patients based on the measurement of biomarkers in a sample of the patient. The biomarkers can be lipids or amino acids or a combination thereof.

Abstract translation: 本发明涉及一种方法，系统和试剂盒，用于基于患者样品中生物标志物的测量来鉴定患有IBD的患者样本或预测患者IBD复发的样本。 生物标志物可以是脂质或氨基酸或其组合。

公开(公告)号：WO2013143839A1

公开(公告)日：2013-10-03

申请号：PCT/EP2013/054987

申请日：2013-03-12

Applicant: NESTEC S.A. ,  INRA

Inventor： BRAHMBHATT, Viral ,  BREUILLE, Denis ,  GUY, Philippe Alexandre ,  MONTOLIU ROURA, Ivan ,  PAPET, Isabelle ,  VIDAL, Karine

IPC: G01N33/68

CPC classification number: G01N33/492 ,  G01N33/6893 ,  G01N2800/7042 ,  G01N2800/7095

Abstract: The present invention relates to a method for predicting the risk of acquiring an age-related low-grade inflammation for a subject, said method comprising a) providing a biological sample from a subject, b) determining in said sample the level of at least one biomarker selected from the group consisting of a compound of molecular weight between 859-863 g/mol and which is an alkylacylphosphatidylcholine, a compound of molecular weight between 861-86 g/mol and which is a diacylphosphatidylcholine, a compound of molecular weight between 791-794 g/mol and which is an alkylacylphosphatidylcholine, a compound of molecular weight between 522-525 g/mol and which is a monoacylphosphatidylcholine, octadecanoylcarnitine (C18), and tryptophan, c) comparing the level of the at least one biomarker to a reference level, and d) determining whether said subject is likely to be at risk of acquiring an age-related low-grade inflammation, when the level of biomarker(s) deviate significantly from the respective reference level.

Abstract translation: 本发明涉及一种用于预测获得受试者年龄相关的低度炎症的风险的方法，所述方法包括：a）从受试者提供生物样品，b）在所述样品中确定至少一种 选自分子量在859-863g / mol之间的化合物，其为烷基酰基磷脂酰胆碱，分子量在861-86g / mol之间的化合物，其为二酰基磷脂酰胆碱，分子量为791的化合物 -794g / mol，其为烷基酰基磷脂酰胆碱，分子量为522-525g / mol的化合物，其为单酰基磷脂酰胆碱，十八烷酰基肉碱（C18）和色氨酸，c）将至少一种生物标志物的水平与 参考水平，以及d）当生物标志物的水平显着偏离呼吸时，确定所述受试者是否可能处于获得年龄相关的低度炎症的风险中 实际参考水平。