公开(公告)号：WO2016048853A1

公开(公告)日：2016-03-31

申请号：PCT/US2015/051127

申请日：2015-09-21

Applicant: NOVARTIS AG ,  CHANG, Frank ,  HUANG, Jinyu ,  SHANKAR, Venkat

Inventor： CHANG, Frank ,  HUANG, Jinyu ,  SHANKAR, Venkat

IPC: C08J3/03 ,  C08J3/075 ,  C08F220/00 ,  C08J3/28 ,  C08G77/20 ,  C08G77/38 ,  C08G77/42 ,  C08G77/442 ,  C08G77/445 ,  C08G77/48 ,  C08L83/06 ,  C08L83/10 ,  C08L83/14 ,  G02B1/04 ,  G02C7/04 ,  C08F290/06 ,  C08L51/08

CPC classification number: G02B1/043 ,  B29D11/00134 ,  B29D11/00192 ,  B29K2083/00 ,  B29K2105/0061 ,  C08F220/00 ,  C08F220/58 ,  C08F230/08 ,  C08F290/068 ,  C08F2220/585 ,  C08G77/20 ,  C08G77/26 ,  C08G77/28 ,  C08G77/38 ,  C08G77/42 ,  C08G77/442 ,  C08G77/445 ,  C08G77/48 ,  C08G2210/00 ,  C08J3/03 ,  C08J3/075 ,  C08J3/28 ,  C08L51/085 ,  C08L83/06 ,  C08L83/10 ,  C08L83/14 ,  G02C7/04 ,  C08L83/04 ,  C08L101/14

Abstract: The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an actinically-polymerizable amphiphilic polysiloxane of the invention.

Abstract translation: 本发明提供了一种光聚合性两亲性聚硅氧烷，其包含聚硅氧烷聚合物链，其包含聚硅氧烷链段，该聚硅氧烷链段包含至少一个硅氧烷单元，该硅氧烷单元具有与硅氧烷单元的硅氧烷原子连接的低分子量亲水性聚合物链和各自的（甲基）丙烯酰胺基 共价键合到聚硅氧烷聚合物链的一个端部和/或每个与一个硅氧烷原子连接的低分子量亲水聚合物链之一的末端。 本发明还涉及聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜，其包含衍生自本发明的可光化聚合的两亲聚硅氧烷的重复单元。 此外，本发明提供了使用包含本发明的可光聚合的两亲性聚硅氧烷的水性透镜形成剂制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2015164630A1

公开(公告)日：2015-10-29

申请号：PCT/US2015/027335

申请日：2015-04-23

Applicant: NOVARTIS AG ,  HUANG, Jinyu ,  CHANG, Frank

Inventor： HUANG, Jinyu ,  CHANG, Frank

IPC: C07F7/08 ,  G02B1/04 ,  C08L83/04

CPC classification number: G02B1/043 ,  C07F7/0852 ,  C07F7/0854 ,  C07F7/1844 ,  C08F30/08 ,  C08F230/08 ,  C08G77/12 ,  C08G77/26 ,  C08L83/04 ,  C08L101/14

Abstract: The invention provides a carbosiloxane vinylic monomer which comprises one sole ethylenically unsaturated group, one sole terminal butyl group; and one oligo(carbosiloxane)- containing linkage between the ethylenically unsaturated terminal group and the terminal butyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a carbosiloxane vinylic monomer of the invention.

Abstract translation: 本发明提供一种碳硅氧烷乙烯基单体，其包含一个唯一的烯键式不饱和基团，一个唯一的末端丁基基团; 和烯属不饱和端基与末端丁基之间的一个低聚（碳硅氧烷）键。 本发明还涉及包含衍生自本发明的碳硅氧烷乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。

公开(公告)号：WO2012016097A3

公开(公告)日：2012-02-02

申请号：PCT/US2011/045809

申请日：2011-07-29

Applicant: NOVARTIS AG ,  CHANG, Frank ,  SCOTT, Robert ,  HUANG, Jinyu ,  MEDINA, Arturo, N. ,  SMITH, Dawn, A. ,  SANDERS, Laura, Ann ,  PRUITT, John, Dallas

Inventor： CHANG, Frank ,  SCOTT, Robert ,  HUANG, Jinyu ,  MEDINA, Arturo, N. ,  SMITH, Dawn, A. ,  SANDERS, Laura, Ann ,  PRUITT, John, Dallas

IPC: C08F26/02 ,  C08F226/00

Abstract: The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.

公开(公告)号：WO2012047969A1

公开(公告)日：2012-04-12

申请号：PCT/US2011/054878

申请日：2011-10-05

Applicant: NOVARTIS AG ,  HUANG, Jinyu ,  CHANG, Frank ,  SCOTT, Robert ,  MEDINA, Arturo Norberto ,  SHANKERNARAYANAN, Manivakkam J. ,  KUYU, Selma ,  SMITH, Dawn, Alison ,  WU, Daqing

Inventor： HUANG, Jinyu ,  CHANG, Frank ,  SCOTT, Robert ,  MEDINA, Arturo Norberto ,  SHANKERNARAYANAN, Manivakkam J. ,  KUYU, Selma ,  SMITH, Dawn, Alison ,  WU, Daqing

IPC: C08G77/42 ,  C08G77/442 ,  C08L83/10 ,  G02B1/04 ,  C08G77/20

CPC classification number: G02B1/043 ,  C08G77/20 ,  C08G77/42 ,  C08G77/442 ,  C08J3/075 ,  C08J2343/04 ,  C08J2383/08 ,  C08L83/10 ,  C08L101/14 ,  C08L83/04

Abstract: The invention provide a class of water-processable polymerizable prepolymers which comprises (1) siloxane-containing monomeric units derived at least one siloxane containing monomer having one hydrophilic group or chain and/or polysiloxane-containing crosslinking units derived from at least one hydrophilized polysiloxane or chain-extended polysiloxane crosslinker; (2) hydrophilic monomeric units derived from one or more hydrophilic vinylic monomers; and (3) from about 0.05% to about 5% by weight of polymerizable units each having a pendant or terminal, ethylenically-unsaturated group and free of any polysiloxane segment. The prepolymer comprises from about 20% to about 50% by weight of silicone relative to the total weight of the prepolymer and has a high water solubility or dispersibility of at least about 5% by weight in water and suitable for making silicone hydrogel contact lenses.

Abstract translation: 本发明提供了一类可水加工的可聚合预聚物，其包含（1）衍生自至少一种含有一个含硅氧烷的单体的含硅氧烷的单体单元，所述单体具有一个亲水基团或至少一种亲水化聚硅氧烷的链和/或含聚硅氧烷的交联单元，或 链延长聚硅氧烷交联剂; （2）衍生自一种或多种亲水乙烯基单体的亲水单体单元; 和（3）约0.05％至约5％重量的各自具有侧基或末端的可聚合单元，烯属不饱和基团并且不含任何聚硅氧烷链段。 预聚物相对于预聚物的总重量包含约20重量％至约50重量％的硅氧烷，并且在水中具有至少约5重量％的高水溶性或分散性，并且适于制备硅酮水凝胶隐形眼镜。

公开(公告)号：WO2012047961A1

公开(公告)日：2012-04-12

申请号：PCT/US2011/054865

申请日：2011-10-05

Applicant: NOVARTIS AG ,  CHANG, Frank ,  HUANG, Jinyu ,  SANDERS, Laura, Ann

Inventor： CHANG, Frank ,  HUANG, Jinyu ,  SANDERS, Laura, Ann

IPC: C08G77/42 ,  C08G77/442 ,  C08L83/10 ,  G02B1/04 ,  C08G77/28 ,  C08G77/48 ,  C08F283/12 ,  C08F290/06 ,  C08G77/20

CPC classification number: C08G77/28 ,  C08F290/068 ,  C08G77/20 ,  C08G77/48 ,  G02B1/043 ,  C08L83/14 ,  C08L83/12

Abstract: The invention provide a class of chain-extended polysiloxane crosslinkers which comprises (1) at least two polylsiloxane segments, wherein each pair of adjacent polysiloxane segments is linked by one divalent organic radical which includes at least one pendant hydrophilic group (hydroxyl and/or carboxyl groups) or at least one dangling hydrophilic polymer chain and a di-thioether linkage -S-DR-S- in which DR is a divalent oranic radical; and (2) two terminal ethylenically unsaturated groups. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.

Abstract translation: 本发明提供一类链延长聚硅氧烷交联剂，其包含（1）至少两个聚硅氧烷链段，其中每对相邻的聚硅氧烷链段通过一个二价有机基团连接，所述二价有机基团包括至少一个侧链亲水基团（羟基和/或羧基 基团）或至少一个悬浮的亲水性聚合物链和二硫醚连接-S-DR-S-，其中DR是二价的基团; 和（2）两个末端烯属不饱和基团。 本发明还涉及包含衍生自本发明的扩链聚硅氧烷交联剂的交联单元和包含这种聚合物的眼用透镜的聚合物。

公开(公告)号：WO2010135481A1

公开(公告)日：2010-11-25

申请号：PCT/US2010/035495

申请日：2010-05-20

Applicant: NOVARTIS AG ,  CHANG, Frank ,  HUANG, Jinyu ,  SCOTT, Robert ,  WANG, Guigui

Inventor： CHANG, Frank ,  HUANG, Jinyu ,  SCOTT, Robert ,  WANG, Guigui

IPC: C08G77/14

CPC classification number: A61K47/32 ,  B29D11/00038 ,  C08F8/14 ,  C08F8/26 ,  C08F230/08 ,  C08F283/12 ,  C08F290/068 ,  C08F291/04 ,  C08F293/005 ,  C08F299/08 ,  C08F2438/01 ,  C08F2810/30 ,  C08F2810/40 ,  C08G77/14 ,  C08G77/26 ,  C08G77/385 ,  C08G77/392 ,  C08J3/075 ,  C08J2300/14 ,  C08J2383/06 ,  C08J2383/07 ,  C08J2383/08 ,  C08L53/00 ,  G02B1/043 ,  G02C7/04 ,  C08F220/56 ,  C08F226/10 ,  C08F220/28 ,  C08L101/14 ,  C08L83/04 ,  C08F220/20

Abstract: The invention provide a class of actinically-crosslinkable silicone-containing prepolymers obtained by functionalizing an intermediary copolymer to have two or more thiol or ethylenically-unsaturated groups covalently attached thereto, wherein the intermediary copolymer is an atom-transfer radical polymerization (ATRP) product of a reactive mixture comprising a polysiloxane ATRP macroinitiator and at least one hydrophilic vinylic monomer. The present invention is also related to silicone hydrogel contact lenses made from a prepolymer of the invention and methods for making the contact lenses in a cost-effective way and with high consistency and high fidelity to the original lens design.

Abstract translation: 本发明提供一类通过官能化中间共聚物获得的具有两个或更多个共价连接到其上的硫醇或烯键式不饱和基团获得的含有机硅的预聚物，其中中间共聚物是原子转移自由基聚合（ATRP） 包含聚硅氧烷ATRP大分子引发剂和至少一种亲水性乙烯基单体的反应性混合物。 本发明还涉及由本发明的预聚物制成的硅酮水凝胶隐形眼镜以及以成本有效的方式制造隐形眼镜并以与原始透镜设计的高一致性和高保真度的方法。

公开(公告)号：WO2012047964A1

公开(公告)日：2012-04-12

申请号：PCT/US2011/054870

申请日：2011-10-05

Applicant: NOVARTIS AG ,  KUYU, Selma ,  SMITH, Dawn, Alison ,  HUANG, Jinyu ,  CHANG, Frank ,  SCOTT, Robert ,  MEDINA, Arturo Norberto ,  SHANKERNARAYANAN, Manivakkam J.

Inventor： KUYU, Selma ,  SMITH, Dawn, Alison ,  HUANG, Jinyu ,  CHANG, Frank ,  SCOTT, Robert ,  MEDINA, Arturo Norberto ,  SHANKERNARAYANAN, Manivakkam J.

IPC: C08G77/42 ,  C08G77/46 ,  C08G77/442 ,  G02B1/04 ,  C08L83/10 ,  C08G77/20

CPC classification number: G02B1/043 ,  A61K47/34 ,  C08G77/20 ,  C08G77/38 ,  C08G77/42 ,  C08G77/442 ,  C08G77/46 ,  C08L83/10 ,  G02B2207/109 ,  C08L83/12 ,  C08L83/14

Abstract: The invention provide a class of linear chain-extended polysiloxane crosslinkers which comprises two terminal ethylenically unsaturated groups, at least two polysiloxane segments, and dangling hydrophilic polymer chains each covalently attached to a divalent organic radical separating each pair of adjacent polysiloxane segments. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.

Abstract translation: 本发明提供一类线性延伸的聚硅氧烷交联剂，其包含两个末端烯键式不饱和基团，至少两个聚硅氧烷链段和悬浮的亲水性聚合物链，每个聚合物链共价连接到分隔每对相邻聚硅氧烷链段的二价有机基团上。 本发明还涉及包含衍生自本发明的延伸链延长聚硅氧烷交联剂的交联单元和包含这种聚合物的眼用透镜的聚合物。

公开(公告)号：WO2015164582A1

公开(公告)日：2015-10-29

申请号：PCT/US2015/027256

申请日：2015-04-23

Applicant: NOVARTIS AG ,  HUANG, Jinyu ,  CHANG, Frank

Inventor： HUANG, Jinyu ,  CHANG, Frank

IPC: C08G77/38 ,  C08F283/12 ,  C08G77/388 ,  C08G77/392 ,  C08G77/395 ,  C08G77/50 ,  G02B1/04

CPC classification number: G02B1/043 ,  C07F7/1844 ,  C07F7/1852 ,  C07F9/09 ,  C07F9/092 ,  C08F230/08 ,  C08F283/124 ,  C08G77/20 ,  C08G77/38 ,  C08G77/388 ,  C08G77/392 ,  C08G77/395 ,  C08G77/50 ,  C08L101/14 ,  C08L83/04 ,  C08L83/14 ,  C08L33/10

Abstract: The invention provides a hydrophilized carbosiloxane vinylic monomer which comprises (1) a poly(carbosiloxane) segment, (2) one sole ethylenically unsaturated group, and (3) at least one terminal or pendant group which is a hydrophilic group or hydrophilic polymer chain. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a hydrophilized carbosiloxane vinylic monomer of the invention.

Abstract translation: 本发明提供亲水化的碳硅氧烷乙烯基单体，其包含（1）聚（碳硅氧烷）链段，（2）一个唯一烯属不饱和基团，和（3）至少一个亲水基团或亲水性聚合物链的末端或侧基。 本发明还涉及包含衍生自本发明的亲水化的碳硅氧烷乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。

公开(公告)号：WO2015048279A1

公开(公告)日：2015-04-02

申请号：PCT/US2014/057442

申请日：2014-09-25

Applicant: NOVARTIS AG ,  CHANG, Frank ,  HUANG, Jinyu ,  DESOUSA, Ryan

Inventor： CHANG, Frank ,  HUANG, Jinyu ,  DESOUSA, Ryan

IPC: C08F230/08 ,  G02B1/04

CPC classification number: C08F230/08 ,  G02B1/043 ,  C08L33/24 ,  C08L43/04 ,  C08L101/14 ,  C08F220/54 ,  C08L83/04

Abstract: The invention provides silicone hydrogel ophthalmic lenses (in particular contact lenses) having relatively-long thermal stability and methods for making such ophthalmic lenses.

Abstract translation: 本发明提供具有相当长的热稳定性的硅酮水凝胶眼用透镜（特别是隐形眼镜）以及制造这种眼科镜片的方法。

公开(公告)号：WO2015089285A1

公开(公告)日：2015-06-18

申请号：PCT/US2014/069752

申请日：2014-12-11

Applicant: NOVARTIS AG ,  MEDINA, Arturo, Norberto ,  HUANG, Jinyu ,  ARD, Katherine ,  LU, Honghui ,  HAKEN, Uwe

Inventor： MEDINA, Arturo, Norberto ,  HUANG, Jinyu ,  ARD, Katherine ,  LU, Honghui ,  HAKEN, Uwe

IPC: B29D11/00 ,  B29C33/64 ,  C09D183/04 ,  G02B1/04

CPC classification number: B29C39/003 ,  B29C33/64 ,  B29D11/00038 ,  B29D11/00192 ,  B29D11/00519 ,  B29K2083/00 ,  C08G77/26 ,  C08G77/44 ,  C08G77/54 ,  C08L83/10 ,  C09D183/04 ,  G02B1/043

Abstract: The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves applying to a molding surface of the mold a layer of mold releasing agent selected from a group consisting of fatty amines of carbon chain length C18 or less and silicones bearing pendant substituted pyrrolidone groups solution to reduce an averaged mold separation force by at least about 50% in comparison with that without the releasing agent.

Abstract translation: 本发明涉及一种用于制造具有改善的镜片质量和增加的产品产量的隐形眼镜的方法和流体组合物。 本发明的方法包括向模具的模制表面施加选自碳链长度为C18或更小的脂肪胺和带有侧取代的吡咯烷酮基团的硅氧烷溶液的脱模剂层，以降低平均的模具分离力 与不含脱模剂相比至少约50％。