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    A MICROFLUIDIC MODULE AND USES THEREOF
    3.
    发明申请
    A MICROFLUIDIC MODULE AND USES THEREOF 审中-公开
    微流控模块及其应用

    公开(公告)号：WO2012154729A1

    公开(公告)日：2012-11-15

    申请号：PCT/US2012/036920

    申请日：2012-05-08

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  DOMANSKY, Karel ,  LESLIE, Daniel C. ,  HAMILTON, Geraldine A. ,  BAHINSKI, Anthony ,  INGBER, Donald E.

    Inventor： DOMANSKY, Karel ,  LESLIE, Daniel C. ,  HAMILTON, Geraldine A. ,  BAHINSKI, Anthony ,  INGBER, Donald E.

    IPC: G01N33/48

    CPC classification number: C12N5/0602 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00833 ,  B01J2219/0084 ,  B01J2219/0086 ,  B01J2219/00907 ,  B01L3/502707 ,  B01L2300/161 ,  B32B37/18 ,  G01N33/54393

    Abstract: Described herein are microfluidic modules and methods for making the same, wherein the microfluidic modules include a substrate comprising at least one ether-based, aliphatic polyurethane, and at least one fluidic element disposed therein. The ether-based aliphatic polyurethane can be either the substrate of the microfluidic modules or a coating of another substrate material, such that at least a portion of the ether-based, aliphatic polyurethane is in fluid communication. In one embodiment, the ether-based, aliphatic polyurethane includes dicyclohexylmethane-4, 4'-diisocyanate. As the ether-based aliphatic polyurethane can decrease absorption of molecules, e.g., hydrophobic molecules, in such microfluidic modules, the microfluidic modules described herein can be used in various applications such as drug screening and fluorescent microscopy.

    Abstract translation: 本文描述的是微流体模块和用于制造其的方法，其中微流体模块包括包含至少一种醚基脂族聚氨酯和设置在其中的至少一个流体元件的基材。 醚基脂肪族聚氨酯可以是微流体模块的基材或另一种基材的涂层，使得至少一部分醚基的脂族聚氨酯与流体连通。 在一个实施方案中，醚基脂族聚氨酯包括二环己基甲烷-4,4'-二异氰酸酯。 由于醚类脂族聚氨酯可以在这种微流体模块中减少分子（例如疏水性分子）的吸收，因此本文所述的微流体模块可用于各种应用，例如药物筛选和荧光显微镜。

    LOW SHEAR MICROFLUIDIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF
    4.
    发明申请
    LOW SHEAR MICROFLUIDIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF 审中-公开
    低剪切微流体器件及其使用方法和制造方法

    公开(公告)号：WO2015138034A2

    公开(公告)日：2015-09-17

    申请号：PCT/US2014/071611

    申请日：2014-12-19

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： INGBER, Donald E. ,  HAJIPOURAN BENAM, Kambez ,  VILLENAVE, Remi ,  HAMILTON, Geraldine A. ,  HASSELL, Bryan ,  HINOJOSA, Christopher D.

    IPC: C12M3/02

    CPC classification number: G01N33/5044 ,  B01L3/5027 ,  C12M21/08 ,  C12M23/16 ,  C12M25/02 ,  C12M35/04 ,  C12M41/46 ,  G01N2800/122

    Abstract: Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.

    Abstract translation: 本文提供了用于生产和使用具有被一个或多个膜分隔开的中央通道的主体的系统和方法。 膜（一个或多个）被配置为将中央通道分成至少一个中途通道和至少一个微通道。 中通道的高度实质上大于微通道的高度。 气态流体可以通过中孔道施加，而液态流体流过微型通道。 本文描述的系统和方法可以用于各种应用，包括例如原代细胞如人肺细胞的生长和分化，以及需要低剪切和/或分层结构的任何其他细胞，或者模拟微环境 活体组织和/或器官（以模拟生理或疾病状态，和/或识别治疗剂和/或疫苗）。 该系统和方法还可以允许与一种或多种不同细胞类型共培养。

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