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公开(公告)号：WO2018226622A1
公开(公告)日：2018-12-13
申请号：PCT/US2018/035954
申请日：2018-06-05
发明人： WOLL, Matthew, G. , AMEDZO, Lukiana , BABU, Suresh , BARRAZA, Scott, J. , BHATTACHARYYA, Anuradha , KARP, Gary, Mitchell , MAZZOTTI, Anthony, R. , NARASIMHAN, Jana , PATEL, Jigar , TURPOFF, Anthony , XU, Zhenrong
IPC分类号： C07D239/74 , C07D239/94 , C07D239/95
摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：WO2019191229A8
公开(公告)日：2019-10-03
申请号：PCT/US2019/024278
申请日：2019-03-27
发明人： SYDORENKO, Nadiya , ALAM, Md, Rauful , AMEDZO, Lukiana , BABU, Suresh , BAIAZITOV, Ramil, Y. , BARRAZA, Scott, J. , BHATTACHARYYA, Anuradha , KARP, Gary, Mitchell , KENTON, Nathaniel, T. , MAZZOTTI, Anthony, R. , MOON, Young-Choon , MSZAR, Nicholas, W. , NARASIMHAN, Jana , PAL, Sudipta , PATEL, Jigar, S. , TURPOFF, Anthony , WOLL, Mathew, G. , XU, Zhenrong , ZHANG, Nanjing
IPC分类号： A61K31/395 , A61K31/53 , A61K47/10 , C07D251/12 , C07D251/16 , C07D401/02
摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：WO2018226622A8
公开(公告)日：2018-12-13
申请号：PCT/US2018/035954
申请日：2018-06-05
发明人： WOLL, Matthew, G. , AMEDZO, Lukiana , BABU, Suresh , BARRAZA, Scott, J. , BHATTACHARYYA, Anuradha , KARP, Gary, Mitchell , MAZZOTTI, Anthony, R. , NARASIMHAN, Jana , PATEL, Jigar , TURPOFF, Anthony , XU, Zhenrong
IPC分类号： C07D239/74 , C07D239/94 , C07D239/95
摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：WO2019191229A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/024278
申请日：2019-03-27
发明人： SYDORENKO, Nadiya , ALAN, Md, Rauful , AMEDZO, Lukiana , BABU, Suresh , BAIAZITOV, Ramil, Y. , BARRAZA, Scott, J. , BHATTACHARYYA, Anuradha , KARP, Gary, Mitchell , KENTON, Nathaniel, T. , MAZZOTTI, Anthony, R. , MOON, Young-Choon , MSZAR, Nicholas, W. , NARASIMHAN, Jana , PAL, Sudipta , PATEL, Jigar, S. , TURPOFF, Anthony , WOLL, Mathew, G. , XU, Zhenrong , ZHANG, Nanjing
IPC分类号： A61K31/395 , A61K31/53 , A61K47/10 , C07D251/12 , C07D251/16 , C07D401/02
摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：WO2017100726A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/066042
申请日：2016-12-11
发明人： BABU, Suresh , BHATTACHARYYA, Anuradha , HWANG, Seongwoo , JANI, Minakshi , MOON, Young-choon , SYDORENKO, Nadiya
IPC分类号： A61K31/506 , C07D405/12 , A61P25/00
CPC分类号： A61K31/506 , C07D237/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10
摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
摘要翻译： 本发明涉及其化合物，形式和药物组合物，以及使用这些化合物，其形式或组合物治疗或改善亨廷顿病的方法。 特别地，本说明书涉及式（I）的取代的单环杂芳基化合物，其形式和药物组合物，以及使用这些化合物，形式或组合物治疗或缓解亨廷顿舞蹈病的方法。
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公开(公告)号：WO2023009816A1
公开(公告)日：2023-02-02
申请号：PCT/US2022/038870
申请日：2022-07-29
发明人： BABU, Suresh , ALAM, Rauful , BHATTACHARYYA, Anuradha , CHEN, Guangming , EASTWOOD, Matthew, S. , HOSSEYNI, Seyedmorteza , JIANG, Yao , KARP, Gary, Mitchell , MOON, Young-choon , NARASIMHAN, Jana , REN, Hongyu , SYDORENKO, Nadiya , WOLL, Matthew, G. , ZHANG, Nanjing
IPC分类号： C07D487/04 , A61P25/14 , A61P25/28 , A61K31/5025
摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington’s disease. In particular, the present description relates to compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington’s disease.
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公开(公告)号：WO2019191092A8
公开(公告)日：2019-10-03
申请号：PCT/US2019/024068
申请日：2019-03-26
发明人： SYDORENKO, Nadiya , BABU, Suresh , BHATTACHARYYA, Anuradha , MOON, Young-Choon , NARASIMHAN, Jana , PATEL, Jigar, S.
IPC分类号： C07D241/12 , C07D241/20 , C07D401/14
摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：WO2019191092A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/024068
申请日：2019-03-26
发明人： SYDORENKO, Nadiya , BABU, Suresh , BHATTACHARYYA, Anuradha , MOON, Young-choon , NARASIMHAN, Jana , PATEL, Jigar, S.
IPC分类号： C07D241/12 , C07D241/20 , C07D401/14
摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：WO2017100726A8
公开(公告)日：2017-06-15
申请号：PCT/US2016/066042
申请日：2016-12-11
发明人： BABU, Suresh , BHATTACHARYYA, Anuradha , HWANG, Seongwoo , JANI, Minakshi , MOON, Young-choon , SYDORENKO, Nadiya
IPC分类号： A61K31/506 , C07D405/12 , A61P25/00
摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：WO2021207453A1
公开(公告)日：2021-10-14
申请号：PCT/US2021/026316
申请日：2021-04-08
发明人： SYDORENKO, Nadiya , ALAM, Md, Rauful , BABU, Suresh , BHATTACHARYYA, Anuradha , CHEN, Guangming , CHIERCHIA, Matteo , KARP, Gary, Mitchell , LUONG, Tom, Tuan , MAZZOTTI, Anthony, R. , MOON, Young-Choon , MSZAR, Nicholas, Walter , NARASIMHAN, Jana , PATEL, Jigar, S. , REN, Hongyu , WANG, Gang , WOLL, Matthew, G. , ZHANG, Nanjing , ZHANG, Xiaoyan
IPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D513/04 , A61K31/53 , A61P25/28
摘要： The present description relates to compounds of Formula (I), forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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