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公开(公告)号：WO2015076800A1
公开(公告)日：2015-05-28
申请号：PCT/US2013/071142
申请日：2013-11-21
发明人： BAIAZITOV, Ramil , CHOI, Soongyu , DU, Wu , HWANG, Seongwoo , LEE, Chang-Sun , LIU, Ronggang , MOON, Young-Choon , PAGET, Steven, D. , REN, Hongyu , SYDORENKO, Nadiya , WILDE, Richard, Gerald
IPC分类号： C07D241/20
CPC分类号： C07D403/04 , A61K31/497 , A61K31/4985 , A61K31/519 , A61K31/69 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07F5/04
摘要： Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B -cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
摘要翻译： 胺取代的吡啶和吡嗪化合物及其形式，其抑制B细胞特异性莫洛尼鼠白血病病毒整合位点1（Bmi-1）蛋白的功能和水平降低，以及它们用于抑制Bmi-1功能和降低水平的方法 的Bmi-1治疗由Bmi-1介导的癌症。
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公开(公告)号：WO2014081906A2
公开(公告)日：2014-05-30
申请号：PCT/US2013/071132
申请日：2013-11-21
发明人： LEE, Chang-Sun , BAIAZITOV, Ramil , CAO, Liangxian , DAVIS, Thomas, W. , DU, Wu , LIU, Ronggang , MOON, Young-choon , PAGET, Steven, D. , REN, Hongyu , SYDORENKO, Nadiya , WILDE, Richard, Gerald
IPC分类号： C07D471/04
CPC分类号： C07D403/12 , A61K31/506 , A61K45/06 , A61N5/10 , C07D403/04 , C07D471/04 , C07D487/04 , Y02A50/411
摘要： Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
摘要翻译： 胺取代的反向嘧啶化合物及其形式，其抑制B细胞特异性莫洛尼鼠白血病病毒整合位点1（Bmi-1）蛋白的功能并降低其水平，及其用于抑制Bmi -1功能并降低Bmi-1的水平以治疗由Bmi-1介导的癌症的方法描述于本文中。
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公开(公告)号：WO2010117935A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/029928
申请日：2010-04-05
申请人： SCHERING CORPORATION , PTC THERAPEUTICS, INC , MACCOSS, Malcolm , NJOROGE, F., George , NOMEIR, Amin , CHEN, Guangming , KARP, Gary, Mitchell , LENNOX, William, Joseph , LI, Chunshi , MORRILL, Christie , PAGET, Steven, D. , REN, Hongyu , ZHANG, Nanjing , ZHANG, Xiaoyan
发明人： MACCOSS, Malcolm , NJOROGE, F., George , NOMEIR, Amin , CHEN, Guangming , KARP, Gary, Mitchell , LENNOX, William, Joseph , LI, Chunshi , MORRILL, Christie , PAGET, Steven, D. , REN, Hongyu , ZHANG, Nanjing , ZHANG, Xiaoyan
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P31/12
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds of formula (I) and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的式（I）化合物及其形式和药物组合物。
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公开(公告)号：WO2021207453A1
公开(公告)日：2021-10-14
申请号：PCT/US2021/026316
申请日：2021-04-08
发明人： SYDORENKO, Nadiya , ALAM, Md, Rauful , BABU, Suresh , BHATTACHARYYA, Anuradha , CHEN, Guangming , CHIERCHIA, Matteo , KARP, Gary, Mitchell , LUONG, Tom, Tuan , MAZZOTTI, Anthony, R. , MOON, Young-Choon , MSZAR, Nicholas, Walter , NARASIMHAN, Jana , PATEL, Jigar, S. , REN, Hongyu , WANG, Gang , WOLL, Matthew, G. , ZHANG, Nanjing , ZHANG, Xiaoyan
IPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D513/04 , A61K31/53 , A61P25/28
摘要： The present description relates to compounds of Formula (I), forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：WO2015076801A1
公开(公告)日：2015-05-28
申请号：PCT/US2013/071153
申请日：2013-11-21
发明人： KOYAMA, Hiroo , BAIAZITOV, Ramil , DU, Wu , LEE, Chang-sun , MOON, Young-Choon , PAGET, Steven, D. , REN, Hongyu , SYDORENKO, Nadiya
IPC分类号： C07D251/18
CPC分类号： C07D403/04 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要： Amine substituted triazine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi- 1 function and reduce the level of Bmi- 1 to treat a cancer mediated by Bmi-1 are described herein.
摘要翻译： 抑制B细胞特异性莫洛尼鼠白血病病毒整合位点1（Bmi-1）蛋白的功能和降低水平的胺取代三嗪化合物及其形式及其用于抑制Bm1功能和降低Bmi水平的方法 1治疗由Bmi-1介导的癌症。
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公开(公告)号：WO2010117932A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/029923
申请日：2010-04-05
申请人： SCHERING CORPORATION , PTC THERAPEUTICS, INC , MACCOSS, Malcolm , NJOROGE, F., George , NOMEIR, Amin , CHEN, Guangming , HUANG, Song, Xiao , KAKARLA, Ramesh , KARP, Gary, Mitchell , LENNOX, William, Joseph , LI, Chunshi , LIU, Ronggang , LIU, Yalei , MORRILL, Christie , PAGET, Steven, D. , SMITH, Sean, W. , TAKASUGI, James , TURPOFF, Anthony, A. , REN, Hongyu , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHU, Jin
发明人： MACCOSS, Malcolm , NJOROGE, F., George , NOMEIR, Amin , CHEN, Guangming , HUANG, Song, Xiao , KAKARLA, Ramesh , KARP, Gary, Mitchell , LENNOX, William, Joseph , LI, Chunshi , LIU, Ronggang , LIU, Yalei , MORRILL, Christie , PAGET, Steven, D. , SMITH, Sean, W. , TAKASUGI, James , TURPOFF, Anthony, A. , REN, Hongyu , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHU, Jin
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61P31/12 , A61K31/4439 , A61K31/444 , A61K31/4436 , A61K31/443 , A61K31/4433 , A61K31/506
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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公开(公告)号：WO2007084435A3
公开(公告)日：2007-07-26
申请号：PCT/US2007/000996
申请日：2007-01-16
申请人： PTC THERAPEUTICS, INC. , KARP, Gary, Mitchell , HWANG, Peter, Seongwoo , TAKASUGI, James, Jan , REN, Hongyu , WILDE, Richard, Gerald , TURPOFF, Anthony, Allan , AREFOLOV, Alexander , CHEN, Guangming , CAMPBELL, Jeffrey Allen
发明人： KARP, Gary, Mitchell , HWANG, Peter, Seongwoo , TAKASUGI, James, Jan , REN, Hongyu , WILDE, Richard, Gerald , TURPOFF, Anthony, Allan , AREFOLOV, Alexander , CHEN, Guangming , CAMPBELL, Jeffrey Allen
IPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14 , A61K31/405 , A61P31/12
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：WO2007084413A3
公开(公告)日：2007-07-26
申请号：PCT/US2007/000923
申请日：2007-01-16
申请人： PTC THERAPEUTICS, INC. , KARP, Gary Mitchell , AREFOLOV, Alexander , REN, Hongyu , TURPOFF, Anthony Allan , WILDE, Richard Gerald , TAKASUGI, James Jan , HWANG, Peter Seongwoo , CHEN, Guangming , CAMPBELL, Jeffrey Allen
发明人： KARP, Gary Mitchell , AREFOLOV, Alexander , REN, Hongyu , TURPOFF, Anthony Allan , WILDE, Richard Gerald , TAKASUGI, James Jan , HWANG, Peter Seongwoo , CHEN, Guangming , CAMPBELL, Jeffrey Allen
IPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14 , A61K31/405 , A61P31/12
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：WO2006019831A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/024881
申请日：2005-07-14
申请人： PTC THERAPEUTICS, INC. , HWANG, Peter Seongwoo , TAKASUGI, James , REN, Hongyu , WILDE, Richard Gerald , TURPOFF, Anthony , AREFOLOV, Alexander , KARP, Gary Mitchell , CHEN, Guangming , CAMPBELL, Jeffrey Allen
发明人： HWANG, Peter Seongwoo , TAKASUGI, James , REN, Hongyu , WILDE, Richard Gerald , TURPOFF, Anthony , AREFOLOV, Alexander , KARP, Gary Mitchell , CHEN, Guangming , CAMPBELL, Jeffrey Allen
IPC分类号： A61K31/404 , A61P31/14
CPC分类号： A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
摘要： In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
摘要翻译： 根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。 在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。
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公开(公告)号：WO2023009816A1
公开(公告)日：2023-02-02
申请号：PCT/US2022/038870
申请日：2022-07-29
发明人： BABU, Suresh , ALAM, Rauful , BHATTACHARYYA, Anuradha , CHEN, Guangming , EASTWOOD, Matthew, S. , HOSSEYNI, Seyedmorteza , JIANG, Yao , KARP, Gary, Mitchell , MOON, Young-choon , NARASIMHAN, Jana , REN, Hongyu , SYDORENKO, Nadiya , WOLL, Matthew, G. , ZHANG, Nanjing
IPC分类号： C07D487/04 , A61P25/14 , A61P25/28 , A61K31/5025
摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington’s disease. In particular, the present description relates to compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington’s disease.
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