PROCESS TO MINIMIZE POLYMORPHISM
    2.
    发明申请
    PROCESS TO MINIMIZE POLYMORPHISM 审中-公开
    最小化多态性的过程

    公开(公告)号:WO2009108775A2

    公开(公告)日:2009-09-03

    申请号:PCT/US2009/035276

    申请日:2009-02-26

    CPC classification number: A61K31/5517 A61K9/06 A61K9/10 A61K31/551 A61K47/42

    Abstract: The commercial formulation of fast dispersing dosage forms (FDDF) requires substantial holding times during which large quantities of pharmaceutically active substance are formed into individual dosage units. During this holding time, pharmaceutical agents with a propensity to polymorphism in an aqueous environment may crystallize into various, and sometimes unpredictable forms. These crystalline forms may affect the efficacy of the pharmaceutical agent. Previous attempts to control this process have included attempts to direct crystallization into a stable form. The instant invention acts to suppress crystallization, by utilizing a combination of standard molecular weight fish gelatin and a low processing temperature, to suppress crystallization to a degree that is not accomplished by either the use of standard molecular weight fish gelatin or low processing temperatures individually.

    Abstract translation: 快速分散剂型(FDDF)的商业制剂需要大量的保持时间,在此期间大量的药物活性物质形成单个剂量单位。 在此期间,具有在含水环境中多晶型倾向的药剂可能会结晶成各种不同的,有时不可预测的形式。 这些结晶形式可能影响药剂的功效。 先前控制该过程的尝试包括尝试将结晶引导至稳定形式。 本发明通过利用标准分子量鱼明胶和低加工温度的组合来抑制结晶,以将结晶抑制到通过使用标准分子量鱼明胶或单独的低加工温度所不能达到的程度。

    CODED MODULATION SCHEME FOR A WIRELESS COMMUNICATION SYSTEM AND METHODS THEREOF
    4.
    发明申请
    CODED MODULATION SCHEME FOR A WIRELESS COMMUNICATION SYSTEM AND METHODS THEREOF 审中-公开
    无线通信系统的编码调制方案及其方法

    公开(公告)号:WO2003017500A1

    公开(公告)日:2003-02-27

    申请号:PCT/SG2001/000165

    申请日:2001-08-17

    Abstract: A wireless communication system (10), an encoding method (300) for encoding a binary input signal and a decoding method (800) for decoding a coded baseband signal within the wireless communication system (10) are described. The system (10) has an encoding section (12) and a decoding section (14). The encoding section (12) has a mapper (26) for mapping bits into symbols, and an encoder (28), coupled to the mapper (26), for encoding the symbols to corresponding integers modulo M, where M is an arbitrary predetermined integer. Coded symbols are derived from the corresponding integers. At the decoding section (14), a decoder (40) decodes an output phasor stream of a coded baseband signal to derive an estimate of a codeword. Thereafter, a demapper (42) demaps the estimate of the codeword to derive the bits from decoded symbols.

    Abstract translation: 描述了无线通信系统(10),用于对二进制输入信号进行编码的编码方法(300)和用于对无线通信系统(10)内的编码基带信号进行解码的解码方法(800)。 系统(10)具有编码部分(12)和解码部分(14)。 编码部分(12)具有用于将比特映射成符号的映射器(26)和耦合到映射器(26)的编码器(28),用于将符号编码为模M的相应整数,其中M是任意的预定整数 。 编码符号来自相应的整数。 在解码部分(14),解码器(40)对编码的基带信号的输出相量流进行解码以导出码字的估计。 此后,解映射器(42)将码字的估计解映射以从解码的符号导出比特。

    FAST DISSOLVING AND TASTE MASKED ORAL DOSAGE FORM COMPRISING SILDENAFIL
    6.
    发明申请
    FAST DISSOLVING AND TASTE MASKED ORAL DOSAGE FORM COMPRISING SILDENAFIL 审中-公开
    快速溶解和烟雾掩蔽的口服剂型包含SILDENAFIL

    公开(公告)号:WO2004017976A1

    公开(公告)日:2004-03-04

    申请号:PCT/GB2003/003636

    申请日:2003-08-20

    Abstract: A fast dissolving and taste masked sildenafil solid dosage form comprising: (i) sildenafil granules which granules comprise at least 45 % by weight of a salt of sildenafil, a solubilisation inhibitor for said salt of sildenafil and optionally a sweetening agent and (ii) one or more disintegrants wherein the disintegrants or combination of disintegrants are present in the form of agglomerates having an average agglomerated particle size of at least 50 µm, said agglomerates comprising at least 10 % by weight of disintegrant.

    Abstract translation: 一种快速溶解和口味掩蔽的西地那非固体剂型,其包含:(i)西地那非颗粒,其颗粒包含至少45重量%的西地那非盐,所述西地那非盐和任选的甜味剂的增溶抑制剂和(ii)一种 或更多的崩解剂,其中崩解剂或崩解剂的组合以平均附聚粒度为至少50μm的附聚物的形式存在,所述附聚物包含至少10重量%的崩解剂。

    CONTROLLED DRUG DELIVERY SYSTEMS PROVIDING VARIABLE RELEASE RATES
    7.
    发明申请
    CONTROLLED DRUG DELIVERY SYSTEMS PROVIDING VARIABLE RELEASE RATES 审中-公开
    控制的药物递送系统提供可变释放率

    公开(公告)号:WO2003007919A1

    公开(公告)日:2003-01-30

    申请号:PCT/GB2002/003286

    申请日:2002-07-18

    CPC classification number: A61K9/209 A61K9/2846 A61K9/2893

    Abstract: A controlled release dosage form with variable release rates comprising: 1) a bilayer or multilayer tablet core in which at least one of the layers contains one or more pharmaceutically active ingredients and at least one of the layers contains one or more rate controlling polymers; 2) a substantially insoluble casing extended over the tablet core covering the majority of tablet surface but leaving a portion of one layer of the table core exposed (exposed layer), the casing resulting from electrostatic deposition of a powder comprising fusible particles onto the tablet core and fusing the particles to form a thin film.

    Abstract translation: 具有可变释放速率的控释剂型包括:1)双层或多层片剂芯,其中至少一层包含一种或多种药物活性成分,并且至少一层包含一种或多种速率控制聚合物; 2)基本上不溶的外壳,其延伸在片芯上,覆盖片剂表面的大部分,但是使桌面芯的一层的一部分暴露(暴露层),由将可熔颗粒的粉末静电沉积到片芯上 并将该颗粒熔合以形成薄膜。

    STRAM WITH ELECTRONICALLY REFLECTIVE INSULATIVE SPACER
    8.
    发明申请
    STRAM WITH ELECTRONICALLY REFLECTIVE INSULATIVE SPACER 审中-公开
    带电子反射绝缘间隔器

    公开(公告)号:WO2010037048A1

    公开(公告)日:2010-04-01

    申请号:PCT/US2009/058643

    申请日:2009-09-28

    CPC classification number: G11C11/161

    Abstract: Spin-transfer torque memory having a specular insulative spacer is disclosed. The spin-transfer torque memory unit (30) includes a free magnetic layer (F6), a reference magnetic layer (RL), an electrically insulating and non-magnetic tunneling barrier layer (TB) separating the free magnetic layer from the reference magnetic layer, an electrode layer (E1, E2) and an electrically insulating and electronically reflective layer (ER) separating the electrode layer and the free magnetic layer.

    Abstract translation: 公开了具有镜面绝缘间隔物的自旋转移力矩存储器。 自旋转移转矩存储单元(30)包括自由磁性层(F6),参考磁性层(RL),将自由磁性层与参考磁性层分离的电绝缘和非磁性隧道势垒层(TB) ,电极层(E1,E2)和分离电极层和自由磁性层的电绝缘和电子反射层(ER)。

    FERROELECTRIC MEMORY USING MULTIFERROICS
    10.
    发明申请
    FERROELECTRIC MEMORY USING MULTIFERROICS 审中-公开
    使用多媒体的电磁记忆

    公开(公告)号:WO2009158053A1

    公开(公告)日:2009-12-30

    申请号:PCT/US2009/038493

    申请日:2009-03-27

    CPC classification number: G11C11/22 H01F10/22 H01F10/24 H01L29/78391

    Abstract: Ferroelectric memory using multiferroics is described. The multiferrroic memory includes a substrate having a source region, a drain region and a channel region separating the source region and the drain region. An electrically insulating layer is adjacent to the source region, drain region and channel region. A data storage cell having a composite multiferroic layer is adjacent to the electrically insulating layer. The electrically insulating layer separates the data storage cell from the channel region. A control gate electrode is adjacent to the data storage cell. The data storage cell separates at least a portion of the control gate electrode from the electrically insulating layer.

    Abstract translation: 描述了使用多铁性的铁电存储器。 多层存储器包括具有源极区,漏极区和分离源极区和漏极区的沟道区的衬底。 电绝缘层与源极区,漏极区和沟道区相邻。 具有复合多铁层的数据存储单元与电绝缘层相邻。 电绝缘层将数据存储单元与沟道区分开。 控制栅电极与数据存储单元相邻。 数据存储单元将控制栅电极的至少一部分与电绝缘层分离。

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