Abstract:
A fast-dissolving dosage form (FDDF) for the delivery of a vaccine is prepared using a formulation containing a starch, optionally, along with at least one additional matrix forming agent, preferably, a combination of gelatin and mannitol, wherein an immune response is induced in a patient in need thereof.
Abstract:
The commercial formulation of fast dispersing dosage forms (FDDF) requires substantial holding times during which large quantities of pharmaceutically active substance are formed into individual dosage units. During this holding time, pharmaceutical agents with a propensity to polymorphism in an aqueous environment may crystallize into various, and sometimes unpredictable forms. These crystalline forms may affect the efficacy of the pharmaceutical agent. Previous attempts to control this process have included attempts to direct crystallization into a stable form. The instant invention acts to suppress crystallization, by utilizing a combination of standard molecular weight fish gelatin and a low processing temperature, to suppress crystallization to a degree that is not accomplished by either the use of standard molecular weight fish gelatin or low processing temperatures individually.
Abstract:
A wireless communication system (10), an encoding method (300) for encoding a binary input signal and a decoding method (800) for decoding a coded baseband signal within the wireless communication system (10) are described. The system (10) has an encoding section (12) and a decoding section (14). The encoding section (12) has a mapper (26) for mapping bits into symbols, and an encoder (28), coupled to the mapper (26), for encoding the symbols to corresponding integers modulo M, where M is an arbitrary predetermined integer. Coded symbols are derived from the corresponding integers. At the decoding section (14), a decoder (40) decodes an output phasor stream of a coded baseband signal to derive an estimate of a codeword. Thereafter, a demapper (42) demaps the estimate of the codeword to derive the bits from decoded symbols.
Abstract:
A multi-phasic, lyophilized, fast-dissolving dosage form (FDDF) for the delivery of a pharmaceutically active ingredient is prepared by sequential dosing of a formulation containing a non-gelling matrix forming agent and a formulation containing a gelling gelatin.
Abstract:
A fast dissolving and taste masked sildenafil solid dosage form comprising: (i) sildenafil granules which granules comprise at least 45 % by weight of a salt of sildenafil, a solubilisation inhibitor for said salt of sildenafil and optionally a sweetening agent and (ii) one or more disintegrants wherein the disintegrants or combination of disintegrants are present in the form of agglomerates having an average agglomerated particle size of at least 50 µm, said agglomerates comprising at least 10 % by weight of disintegrant.
Abstract:
A controlled release dosage form with variable release rates comprising: 1) a bilayer or multilayer tablet core in which at least one of the layers contains one or more pharmaceutically active ingredients and at least one of the layers contains one or more rate controlling polymers; 2) a substantially insoluble casing extended over the tablet core covering the majority of tablet surface but leaving a portion of one layer of the table core exposed (exposed layer), the casing resulting from electrostatic deposition of a powder comprising fusible particles onto the tablet core and fusing the particles to form a thin film.
Abstract:
Spin-transfer torque memory having a specular insulative spacer is disclosed. The spin-transfer torque memory unit (30) includes a free magnetic layer (F6), a reference magnetic layer (RL), an electrically insulating and non-magnetic tunneling barrier layer (TB) separating the free magnetic layer from the reference magnetic layer, an electrode layer (E1, E2) and an electrically insulating and electronically reflective layer (ER) separating the electrode layer and the free magnetic layer.
Abstract:
Ferroelectric memory using multiferroics is described. The multiferrroic memory includes a substrate having a source region, a drain region and a channel region separating the source region and the drain region. An electrically insulating layer is adjacent to the source region, drain region and channel region. A data storage cell having a composite multiferroic layer is adjacent to the electrically insulating layer. The electrically insulating layer separates the data storage cell from the channel region. A control gate electrode is adjacent to the data storage cell. The data storage cell separates at least a portion of the control gate electrode from the electrically insulating layer.