公开(公告)号：WO2003073088A3

公开(公告)日：2003-09-04

申请号：PCT/GB2002/000965

申请日：2002-03-11

Applicant: TOUMAZOU, Christofer ,  PURUSHOTHAMAN, Sunil

Inventor： TOUMAZOU, Christofer ,  PURUSHOTHAMAN, Sunil

IPC: G01N27/414

Abstract: Sensor and method to detect localised fluctuations of ionic charge indicating events occuring during a chemical reaction, the sensing apparatus comprising an ion sensitive field effect transistor arranged to generate an electrical output signal in response to localised fluctuations of ionic charge at or adjacent the surface of the transistor, and means for detecting the electrical output signal from the field effect transistor is provided with a polymerase linked layer and the chemical reaction is DNA synthesis, and the localised fluctuations of ionic charge indicate the insertion of di-deoxynucleotide triphosphates and deoxynucleotide triphosphates by detecting a change of hydronium ions with a sensitive Si 3 N 4 layer of the field effect transistor.

公开(公告)号：WO2008107014A1

公开(公告)日：2008-09-12

申请号：PCT/EP2007/052010

申请日：2007-03-02

Applicant: DNA ELECTRONICS LTD ,  TOUMAZOU, Christofer ,  PURUSHOTHAMAN, Sunil

Inventor： TOUMAZOU, Christofer ,  PURUSHOTHAMAN, Sunil

IPC: C12Q1/68 ,  G01N27/414

CPC classification number: C12Q1/6851 ,  G01N27/4145 ,  C12Q2565/607 ,  C12Q2561/113 ,  C12Q2527/119

Abstract: Use of a pH sensor comprising an ion-sensitive field effect transistor (ISFET) to perform real time detection/ quantification of nucleic acid amplification, e.g. polymerase chain reaction (PCR) nucleic acid amplification, based on detection of protons released during the primer extension phase.

Abstract translation: 使用包含离子敏感场效应晶体管（ISFET）的pH传感器来执行核酸扩增的实时检测/定量，例如， 基于检测在引物延伸期释放的质子的聚合酶链反应（PCR）核酸扩增。

公开(公告)号：WO2013024044A2

公开(公告)日：2013-02-21

申请号：PCT/EP2012/065725

申请日：2012-08-10

Applicant: GENE ONYX LIMITED ,  TOUMAZOU, Christofer ,  GEORGIOU, Pantelis ,  VINAS, Pau Herrero ,  SIM, Calvin

Inventor： TOUMAZOU, Christofer ,  GEORGIOU, Pantelis ,  VINAS, Pau Herrero

IPC: G06F19/00

CPC classification number: A61M5/1723 ,  A61M5/142 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468

Abstract: The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimising the gain factor based on the historical data in relation to the patient.

Abstract translation: 用于控制胰岛素泵的控制器单元和方法技术领域本发明涉及用于控制胰岛素泵的控制器单元和方法。 控制器单元包括接收增益因子的用户输入。 增益因子是根据与患者相关的历史数据计算出来的。 控制器单元包括用于接收代表患者的测量的血糖水平的数据的测量输入。 控制器单元的处理逻辑被配置为将测量的血糖水平应用于胰腺β-细胞胰岛素分泌计算模型以预测胰岛素输出水平，将增益因子应用于预测的胰岛素输出水平以确定患者胰岛素缺乏水平， 并基于患者胰岛素缺乏水平计算用于控制胰岛素泵的胰岛素输出水平的控制信号。 提供了基于与患者有关的历史数据优化增益因子的方法。

公开(公告)号：WO2011110873A1

公开(公告)日：2011-09-15

申请号：PCT/GB2011/050501

申请日：2011-03-14

Applicant: DNA ELECTRONICS LTD ,  TOUMAZOU, Christofer ,  KALOFONOU, Melpomeni

Inventor： TOUMAZOU, Christofer ,  KALOFONOU, Melpomeni

IPC: C12Q1/68 ,  G01N27/414

CPC classification number: G01N27/4145 ,  C12Q1/6825 ,  C12Q1/6827 ,  C12Q1/6858 ,  C12Q1/6869 ,  C12Q2523/125 ,  C12Q2527/119 ,  C12Q2565/607

Abstract: The use of ion sensitive field effect transistor (ISFET) to detect methylated nucleotides in a DNA sample is described. A method of detecting methylated nucleotides in a DNA sample may include the steps of treating a sample of DNA with a reagent which discriminates between methylated and non-methylated nucleotides to provide treated DNA, amplifying the treated DNA and optionally sequencing the amplified DNA. An ISFET is used to monitor the addition of one or more dNTPs in the strand extension reactions during the amplification and/or sequencing step. Suitable apparatus is also provided.

Abstract translation: 描述了使用离子敏感场效应晶体管（ISFET）来检测DNA样品中的甲基化核苷酸。 检测DNA样品中的甲基化核苷酸的方法可以包括用鉴别甲基化和非甲基化核苷酸之间的试剂处理DNA样品以提供处理的DNA，扩增经处理的DNA和任选地对扩增的DNA进行测序的步骤。 ISFET用于监测在扩增和/或测序步骤期间在链延伸反应中添加一种或多种dNTP。 还提供了合适的装置。

公开(公告)号：WO2003017180A1

公开(公告)日：2003-02-27

申请号：PCT/GB2002/003796

申请日：2002-08-16

Applicant: TOUMAZ TECHNOLOGY LIMITED ,  BURDETT, Alison ,  TOUMAZOU, Christofer

Inventor： BURDETT, Alison ,  TOUMAZOU, Christofer

IPC: G06J1/00

CPC classification number: G06J1/00

Abstract: A circuit comprising a digital processor, analogue processing means, a digital to analogue converter for converting digital values output from the digital processor into analogue values which are processed by the analogue processing means, and an analogue to digital converter for converting resulting analogue values into digital values for input to the digital processor, wherein the analogue processing means comprises one or more analogue processors, and the circuit is dynamically reconfigurable under the control of the digital processor, such that analogue values are processed according to a first function by the analogue processing means, and following reconfiguration, analogue values are processed according to a second function by the analogue processing means.

Abstract translation: 一种包括数字处理器，模拟处理装置，用于将从数字处理器输出的数字值转换成由模拟处理装置处理的模拟值的数模转换器的电路，以及用于将所得到的模拟值转换为数字 用于输入到数字处理器的值，其中所述模拟处理装置包括一个或多个模拟处理器，并且所述电路在数字处理器的控制下动态地可重新配置，使得模拟值根据模拟处理装置根据第一功能被处理 ，并且在重新配置之后，通过模拟处理装置根据第二功能处理模拟值。

公开(公告)号：WO2012098409A1

公开(公告)日：2012-07-26

申请号：PCT/GB2012/050125

申请日：2012-01-20

Applicant: DNA ELECTRONICS LTD ,  PRODROMAKIS, Themistoklis ,  TOUMAZOU, Christofer

Inventor： PRODROMAKIS, Themistoklis ,  TOUMAZOU, Christofer

IPC: G01N27/414

CPC classification number: G01N27/4148

Abstract: A chemical sensor having a substrate, an electrode formed on or within the substrate, a chemical sensing area formed on the electrode, and coupling means on the substrate to couple the electrode to an active device arranged to receive a signal from the electrode. The active device comprises a transducer arranged to receive the signal from the electrode and provide an output signal. The signal corresponds to the concentration of ions in a sample in contact with the sensor. The sensor may be used to detect neural transmitters in a neural tissue.

Abstract translation: 具有衬底，形成在衬底上或衬底内的电极的化学传感器，形成在电极上的化学感测区域以及衬底上的耦合装置，以将电极耦合到被布置成从电极接收信号的有源器件。 有源器件包括被布置成从电极接收信号并提供输出信号的换能器。 该信号对应于与传感器接触的样品中的离子浓度。 传感器可用于检测神经组织中的神经传递器。

公开(公告)号：WO2012017424A1

公开(公告)日：2012-02-09

申请号：PCT/IB2011/053900

申请日：2011-09-06

Applicant: DNA ELECTRONICS LTD ,  PRODROKAKIS, Themistoklis ,  TOUMAZOU, Christofer

Inventor： PRODROKAKIS, Themistoklis ,  TOUMAZOU, Christofer

IPC: G01N27/12 ,  G01N27/327 ,  G01N33/543

CPC classification number: G01N27/60 ,  G01N27/127 ,  G01N27/3278 ,  G01N33/5438

Abstract: A sensor comprising a memory device having a first electrode and a first chemical- sensing layer coupled to the first electrode. The chemical-sensing layer, in the presence of an analyte, is arranged to change a property of the Memristive device. The sensor can detect an analyte by providing a sample to be detected proximate the chemical sensing layer, observing the state of the memory element; and determining a property of the sample by comparing the observed state of the memory element with a previous state. The sensor is manufactured by depositing a second electrode on a surface, depositing an active layer or layers onto said second electrode, depositing a first electrode onto said active layer(s), and coupling a chemically sensitive layer to the first electrode.

Abstract translation: 一种传感器，包括具有第一电极和耦合到第一电极的第一化学感测层的存储器件。 在分析物存在下的化学感测层被布置成改变记忆装置的性质。 传感器可以通过在化学感测层附近提供要检测的样本来检测分析物，观察存储元件的状态; 以及通过将所述存储元件的观察状态与先前状态进行比较来确定所述样本的属性。 通过在表面上沉积第二电极来制造传感器，将活性层沉积到所述第二电极上，在第一电极上沉积第一电极，以及将化学敏感层耦合到第一电极。

公开(公告)号：WO2004042931A2

公开(公告)日：2004-05-21

申请号：PCT/GB2003/004828

申请日：2003-11-06

Applicant: TOUMAZ TECHNOLOGY LIMITED ,  SIM, Calvin ,  TOUMAZOU, Christofer

Inventor： SIM, Calvin ,  TOUMAZOU, Christofer

IPC: H03M1/00

CPC classification number: H03M1/66

Abstract: Apparatus for converting an M-bit digital signal into an analogue signal. The apparatus comprising means (12,13) for mapping the M-bit digital signal to first and second digital values, so that the ratio of the first to the second digital value is equal to or approximates the value of the M-bit digital signal. First and second digital to analogue converters (14,15) are provided, the first digital to analogue converter (14) having an input for receiving said first digital value and the second digital to analogue converter (15) having an input for receiving said second digital value. Circuit means (16) is coupled to the analogue outputs of the digital to analogue converters (14,15) for dividing one of the analogue outputs by the other, and for providing the result to an output.

Abstract translation: 用于将M位数字信号转换成模拟信号的设备。 该装置包括用于将M位数字信号映射成第一和第二数字值的装置（12,13），以便第一和第二数字值的比率等于或接近M位数字信号的值 。 提供第一和第二数模转换器（14,15），第一数模转换器（14）具有用于接收所述第一数字值的输入端和第二数模转换器（15），所述第二数模转换器具有用于接收所述第二 数字值。 电路装置（16）耦合到数模转换器（14,15）的模拟输出端，用于将另一个模拟输出端分开，并将结果提供给输出端。

公开(公告)号：WO2013132202A1

公开(公告)日：2013-09-12

申请号：PCT/GB2012/050494

申请日：2012-03-06

Applicant: DNA ELECTRONICS LTD ,  TOUMAZOU, Christofer ,  LIU, Yan

Inventor： TOUMAZOU, Christofer ,  LIU, Yan

IPC: G01N27/414 ,  G01N27/416

CPC classification number: G01N31/16 ,  G01N27/4148

Abstract: There is provided a method and device for measuring an ion concentration of a sample. The method comprises exposing a chemical sensor to the sample to provide an electrical output signal 5 representing said ion concentration and controlling a titrator exposed to the sample to release or absorb a quantity of ions to the sample. The method may use feedback means comprising Pulse Width Modulation control to drive the titrator such that the sample maintains a stable ion concentration.

Abstract translation: 提供了用于测量样品的离子浓度的方法和装置。 该方法包括将化学传感器暴露于样品以提供代表所述离子浓度的电输出信号5并控制暴露于样品的滴定剂以释放或吸收一定量的离子到样品。 该方法可以使用包括脉宽调制控制的反馈装置来驱动滴定器，使样品保持稳定的离子浓度。

公开(公告)号：WO2013010685A1

公开(公告)日：2013-01-24

申请号：PCT/EP2012/055441

申请日：2012-03-27

Applicant: GENE ONYX LTD ,  TOUMAZOU, Christofer ,  SIM, Calvin

Inventor： TOUMAZOU, Christofer ,  SIM, Calvin

IPC: G06F19/00 ,  G06Q30/0631

CPC classification number: G06F19/3475 ,  G06F19/00 ,  G06F19/3456 ,  G06Q30/0631 ,  G16H10/20 ,  G16H10/40

Abstract: A method of selecting a product suited to an individual. The method comprises: identifying a product category from a predefined set of product categories, each product category being associated with a set of products; on the basis of said selected product category, selecting a genetic testing cartridge type from a set of available cartridge types, each cartridge type being configured to perform a genotype profiling test on a polynucleotide sample; collecting a polynucleotide sample from the individual; performing a genotype profiling test on said polynucleotide sample using a genetic testing cartridge of the selected genetic testing cartridge type; and using the result of said test to select a product from within the identified product category.

Abstract translation: 选择适合个人的产品的方法。 该方法包括：从预定义的一组产品类别中识别产品类别，每个产品类别与一组产品相关联; 基于所选择的产品类别，从一组可用的盒类型中选择遗传测试盒类型，每个盒类型被配置为对多核苷酸样品执行基因型分析测试; 从个体收集多核苷酸样品; 使用所选遗传测试盒型的遗传测试盒对所述多核苷酸样品进行基因型分析测试; 并使用所述测试的结果从所识别的产品类别内选择产品。