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    METHODS FOR SPLIT-PROTEIN TEMPLATE ASSEMBLY BY PROXIMITY-ENHANCED REACTIVITY
    2.
    发明申请
    METHODS FOR SPLIT-PROTEIN TEMPLATE ASSEMBLY BY PROXIMITY-ENHANCED REACTIVITY 审中-公开

    公开(公告)号：WO2018093978A2

    公开(公告)日：2018-05-24

    申请号：PCT/US2017/061907

    申请日：2017-11-16

    Applicant: TRIBIOTICA LLC

    Inventor： DUNN, Ian ,  LAWLER, Matthew

    Abstract: Compounds, composition, and kits are provided for use in methods for the assisted folding of protein fragments of a larger protein by means of induced proximity, forced by specific nucleic acid hybridizations between a target nucleic acid molecule and complementary nucleic acid molecules appended to the protein fragments of interest.

    METHODS FOR USING NUCLEIC ACID APTAMERS FOR DIRECTED TEMPLATED ASSEMBLY
    6.
    发明申请
    METHODS FOR USING NUCLEIC ACID APTAMERS FOR DIRECTED TEMPLATED ASSEMBLY 审中-公开
    使用核酸沉淀物定向模板组装的方法

    公开(公告)号：WO2017205277A2

    公开(公告)日：2017-11-30

    申请号：PCT/US2017/033807

    申请日：2017-05-22

    Applicant: TRIBIOTICA LLC

    Inventor： DUNN, Ian ,  LAWLER, Matthew

    IPC: C12N15/10 ,  C12N15/115

    Abstract: The present disclosure provides nucleic acid aptamers, nucleic acid aptamers hybridized to haplomers, methods of using nucleic acid aptamers to present template sequences, where the aptamers bind to target molecules unique to specific cellular targets, for the purpose of nucleic acid-templated assembly of molecules with desired functions.

    Abstract translation: 本公开内容提供了核酸适体，与单体杂交的核酸适体，使用核酸适体呈递模板序列的方法，其中适体结合特定细胞靶标特有的靶分子，目的 具有所需功能的分子的核酸模板化装配。

    METHODS AND KITS FOR THERANOSTIC APPLICATIONS
    7.
    发明申请
    METHODS AND KITS FOR THERANOSTIC APPLICATIONS 审中-公开
    治疗应用的方法和工具

    公开(公告)号：WO2016089958A1

    公开(公告)日：2016-06-09

    申请号：PCT/US2015/063368

    申请日：2015-12-02

    Applicant: TRIBIOTICA LLC

    Inventor： DUNN, Ian ,  LAWLER, Matthew

    IPC: C40B40/00 ,  C40B20/00 ,  C12Q1/68

    CPC classification number: C12Q1/6816 ,  C12N15/1093 ,  C12Q2533/107 ,  C12Q2563/107 ,  C40B20/00 ,  C40B40/00

    Abstract: The present disclosure is directed to methods and kits for identifying, enriching, and evaluating templated assembly reactants. Some embodiments disclose methods for identifying templated assembly targets by synthesizing templated assembly reactants, hybridizing the templated assembly reactants to target nucleic acids, performing a templated assembly reaction, and identifying the target nucleic acids that hybridized to the templated assembly reactants. Libraries of templated assembly reactants, a kit for identifying templated assembly targets, and a pair of templated assembly targets enriched from a library of chemically-ligated oligonucleotides spatially elicited (CLOSE) products are also disclosed.

    Abstract translation: 本公开涉及用于鉴定，富集和评估模板化组装反应物的方法和试剂盒。 一些实施方案公开了通过合成模板化组装反应物，将模板化组装反应物与靶核酸杂交，进行模板化装配反应以及鉴定与模板组装反应物杂交的靶核酸来鉴定模板化装配目标的方法。 还公开了模板组装反应物的库，用于鉴定模板化装配靶标的试剂盒和从空间引发（CLOSE）产物的化学连接寡核苷酸文库富集的一对模板装配靶标。

    METHODS AND COMPOSITIONS FOR TEMPLATED ASSEMBLY OF NUCLEIC ACID SPECIFIC HETEROCOMPOUNDS
    8.
    发明申请
    METHODS AND COMPOSITIONS FOR TEMPLATED ASSEMBLY OF NUCLEIC ACID SPECIFIC HETEROCOMPOUNDS 审中-公开
    核酸特异性杂交体的组装方法及组合物

    公开(公告)号：WO2014197547A1

    公开(公告)日：2014-12-11

    申请号：PCT/US2014/040822

    申请日：2014-06-04

    Applicant: TRIBIOTICA LLC

    Inventor： DUNN, Ian ,  LAWLER, Matthew

    IPC: C12N15/11

    CPC classification number: A61K47/48092 ,  A61K39/0011 ,  A61K47/549 ,  A61K2039/5158 ,  A61K2039/6025 ,  C12N15/1068 ,  C12N15/111 ,  C12N15/1131 ,  C12N2310/351 ,  C12N2310/3513 ,  C12N2310/3517 ,  C12N2320/30 ,  C12Q1/6811 ,  C12N2310/321 ,  C12N2310/3521 ,  C12Q2543/10 ,  C12Q2523/109

    Abstract: The present disclosure is directed methods and products for synthesizing and using targeted templated assembly reactants comprising at least one nucleic acid recognition moiety, at least one selectively-reactive moiety, and at least one effector partial moiety. The nucleic acid recognition moiety can bind a target nucleic acid sequence within a sample. The nucleic acid recognition moiety also can bind the selectively-reactive moiety. Additionally, the effector partial moiety can bind the selectively-reactive moiety to produce an active effector structure. Also disclosed are methods of delivering the targeted templated assembly reactants and active effector structures formed from the targeted templated assembly reactants.

    Abstract translation: 本公开内容涉及用于合成和使用包含至少一个核酸识别部分，至少一个选择性反应性部分和至少一个效应子部分部分的靶向模板组装反应物的方法和产品。 核酸识别部分可以结合样品内的靶核酸序列。 核酸识别部分还可以结合选择性反应性部分。 此外，效应子部分部分可以结合选择性反应性部分以产生活性效应结构。 还公开了递送由目标模板组装反应物形成的目标模板组装反应物和活性效应结构的方法。

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