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    QUANTIFICATION OF OPTICAL ABSORPTION COEFFICIENTS USING ACOUSTIC SPECTRA IN PHOTOACOUSTIC TOMOGRAPHY
    2.
    发明申请
    QUANTIFICATION OF OPTICAL ABSORPTION COEFFICIENTS USING ACOUSTIC SPECTRA IN PHOTOACOUSTIC TOMOGRAPHY 审中-公开
    光学吸收光谱吸收光谱数据的量化

    公开(公告)号：WO2011127428A2

    公开(公告)日：2011-10-13

    申请号：PCT/US2011/031823

    申请日：2011-04-08

    申请人： WASHINGTON UNIVERSITY ,  GUO, Zijian ,  WANG, Lihong

    发明人： GUO, Zijian ,  WANG, Lihong

    IPC分类号： G01N21/31 ,  G01N21/27 ,  G01N29/46

    CPC分类号： A61B5/0095 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/417 ,  A61B5/7257 ,  A61B8/13 ,  A61B8/5215 ,  A61B2576/00 ,  G01N21/1702

    摘要： Accurately quantifying optical absorption coefficient using acoustic spectra of photoacoustic signals. Optical absorption is closely associated with many physiological parameters, such as the concentration and oxygen saturation of hemoglobin, and it can be used to quantify the concentrations of non-fluorescent molecules. A sample is illuminated by, for example, a pulsed laser and following the absorption of optical energy, a photoacoustic pressure is generated via thermo-elastic expansion. The acoustic waves then propagate and are detected by a transducer. The optical absorption coefficient of the sample is quantified from spectra of the measured photoacoustic signals. Factors, such as system bandwidth and acoustic attenuation, may affect the quantification but are canceled by dividing the acoustic spectra measured at multiple optical wavelengths.

    摘要翻译： 使用光声信号的声谱精确量化光吸收系数。 光吸收与许多生理参数密切相关，如血红蛋白的浓度和氧饱和度，可用于量化非荧光分子的浓度。 样品通过例如脉冲激光照射，并且随着光能的吸收，通过热弹性膨胀产生光声压力。 然后声波传播并由换能器检测。 样品的光吸收系数由测量的光声信号的光谱量化。 诸如系统带宽和声衰减的因素可能影响量化，但是通过除以在多个光波长处测量的声谱被抵消。

    PHOTOACOUSTIC COMPUTED TOMOGRAPHY WITH AN ACOUSTIC REFLECTOR
    4.
    发明申请
    PHOTOACOUSTIC COMPUTED TOMOGRAPHY WITH AN ACOUSTIC REFLECTOR 审中-公开
    具有声学反射器的光电计算机断层扫描

    公开(公告)号：WO2015073523A1

    公开(公告)日：2015-05-21

    申请号：PCT/US2014/065195

    申请日：2014-11-12

    申请人： WASHINGTON UNIVERSITY

    发明人： WANG, Lihong ,  HUANG, Bin ,  XIA, Jun ,  MASLOV, Konstantin ,  ANASTASIO, Mark

    IPC分类号： G02F1/11

    CPC分类号： A61B5/0095 ,  A61B5/0042 ,  A61B8/4245 ,  A61B8/4483 ,  A61B2503/40 ,  A61B2562/0204

    摘要： Systems and methods for improving limited-view photoacoustic tomography using an acoustic reflector are described. In particular, an acoustic reflector and ultrasonic transducer array are integrated to provide a virtual array that enhances the field of view of the ultrasonic transducer array, thereby improving the quality of photoacoustic tomography images obtained using the systems and methods described herein.

    摘要翻译： 描述了使用声反射器改进有限视场光声层析成像的系统和方法。 特别地，声反射器和超声换能器阵列被集成以提供增强超声波换能器阵列的视场的虚拟阵列，从而提高使用本文所述的系统和方法获得的光声层析成像的质量。

    MINIATURIZED PHOTOACOUSTIC IMAGING APPARATUS INCLUDING A ROTATABLE REFLECTOR
    6.
    发明申请
    MINIATURIZED PHOTOACOUSTIC IMAGING APPARATUS INCLUDING A ROTATABLE REFLECTOR 审中-公开
    微型摄影成像设备，包括可旋转反射器

    公开(公告)号：WO2010080991A2

    公开(公告)日：2010-07-15

    申请号：PCT/US2010/020488

    申请日：2010-01-08

    申请人： WASHINGTON UNIVERSITY IN ST. LOUIS ,  WANG, Lihong ,  MASLOV, Konstantin ,  YANG, Joon-Mo

    发明人： WANG, Lihong ,  MASLOV, Konstantin ,  YANG, Joon-Mo

    IPC分类号： A61B1/00

    CPC分类号： A61B5/0095 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/08 ,  A61B5/0873 ,  A61B8/12 ,  A61B8/4461

    摘要： A reflection-mode photoacoustic endoscope includes a light source configured to emit a light pulse, a signal detection or transmission unit configured to detect or emit an ultrasonic pulse, and a rotatable reflector. The rotatable reflector is configured to reflect at least one of the light pulse and the ultrasonic pulse into a target area of an object, and reflect a response signal to the signal detection unit. The response signal is one of a photoacoustic wave generated by the object responsive to the light pulse and an ultrasonic pulse echo generated by the object responsive to the ultrasonic pulse.

    摘要翻译： 反射型光声内窥镜包括配置为发射光脉冲的光源，被配置为检测或发射超声脉冲的信号检测或发送单元和可旋转反射器。 可旋转反射器被配置为将光脉冲和超声波脉冲中的至少一个反射到物体的目标区域中，并将响应信号反映到信号检测单元。 响应信号是响应于光脉冲的物体产生的光声波和响应于超声波脉冲的物体产生的超声脉冲回波之一。

    SYSTEMS AND METHODS OF GRUENEISEN-RELAXATION PHOTOACOUSTIC MICROSCOPY AND PHOTOACOUSTIC WAVEFRONT SHAPING
    10.
    发明申请
    SYSTEMS AND METHODS OF GRUENEISEN-RELAXATION PHOTOACOUSTIC MICROSCOPY AND PHOTOACOUSTIC WAVEFRONT SHAPING 审中-公开
    松散光电显微镜和光电波形形状的系统和方法

    公开(公告)号：WO2015077355A1

    公开(公告)日：2015-05-28

    申请号：PCT/US2014/066437

    申请日：2014-11-19

    申请人： WASHINGTON UNIVERSITY

    发明人： WANG, Lihong ,  WANG, Lidai ,  ZHANG, Chi ,  LAI, Puxiang ,  TAY, Jian Wei

    IPC分类号： G02B21/00

    CPC分类号： G01N29/2418 ,  G01N2201/06113 ,  G02B21/0004 ,  G02B21/002 ,  G02B21/0028 ,  G02B21/008

    摘要： Systems and methods for focusing a light pulse within a focus area using nonlinear photoacoustic wavefront shaping (PAWS) are disclosed herein. The method includes modulating a spatial phase pattern of a light pulse's waveform based on a Grueneisen-relaxation photoacoustic (GR-PA) feedback signal. In addition, systems and methods for performing Grueneisen-relaxation photoacoustic microscopy (GR-PAM) are disclosed herein that include analyzing photoacoustic signals resulting from illumination of a focus region by two closely spaced light pulses. A method of obtaining an absorption coefficient of a sample using Grueneisen-relaxation photoacoustic microscopy (GR-PAM) is also disclosed.

    摘要翻译： 本文公开了使用非线性光声波前整形（PAWS）在聚焦区域内聚焦光脉冲的系统和方法。 该方法包括基于Grueneisen-relaxation光声（GR-PA）反馈信号调制光脉冲波形的空间相位图。 此外，本文公开了用于执行Grueneisen-relaxation光声显微镜（GR-PAM）的系统和方法，其包括分析由两个紧密间隔的光脉冲照射聚焦区域而产生的光声信号。 还公开了使用Grueneisen-relaxation光声显微镜（GR-PAM）获得样品的吸收系数的方法。