公开(公告)号：WO2018175346A1

公开(公告)日：2018-09-27

申请号：PCT/US2018/023182

申请日：2018-03-19

Applicant: SPECTRAL PLATFORMS, INC.

Inventor： VERMA, Ravi ,  YU, Changjun

IPC: G01N33/58 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/06 ,  C12Q1/08 ,  C12Q1/18 ,  C12Q1/20 ,  C07H21/02

CPC classification number: G01N21/65 ,  C12Q1/04 ,  C12Q1/14 ,  C12Q1/18 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6486 ,  G01N2201/06113

Abstract: Resonant Raman spectroscopy including irradiating a sample with a monochromatic light source at a first irradiation intensity and a second irradiation intensity, determining the intensity of one or more of the Resonant Raman scattering and fluorescence scattering at the first irradiation intensity and second irradiation intensity, calculating a rate of change of one or more of the intensity of Resonant Raman scattering and fluorescence in response to the change in irradiation intensity from the first irradiation intensity to the second irradiation intensity and comparing one or more of the rate of change in the intensity of Resonant Raman scattering and the rate of change in the intensity of fluorescence scattering with the rate of change in the irradiation intensity by the monochromatic light source to determine the Resonant Raman response of the sample.

公开(公告)号：WO2017197271A1

公开(公告)日：2017-11-16

申请号：PCT/US2017/032417

申请日：2017-05-12

Applicant: BD BIOSCIENCES

Inventor： DIEBOLD, Eric ,  OWSLEY, Keegan ,  LIN, Jonathan ,  BAHR, Matthew

IPC: G01N15/14 ,  G06T7/521 ,  G01N21/53 ,  G01N21/64

CPC classification number: G01N15/1475 ,  G01N15/1429 ,  G01N15/147 ,  G01N21/6456 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/144 ,  G01N2201/06113 ,  G01N2201/10 ,  G01N2201/12 ,  G01N2201/129 ,  G06T7/0012 ,  G06T7/246 ,  G06T7/521 ,  G06T2207/30024

Abstract: In one aspect, a system for performing flow cytometry is disclosed, which comprises a laser for generating laser radiation for illuminating a sample, at least one detector for detecting at least a portion of a radiation emanating from the sample in response to said illumination so as to generate a temporal signal corresponding to said detected radiation, and an analysis module for receiving said temporal signal and performing a statistical analysis of said signal based on a forward model to reconstruct an image of said sample.

Abstract translation: 在一个方面，公开了用于执行流式细胞术的系统，其包括用于产生激光辐射以照射样本的激光器，至少一个检测器，用于检测从所述激光辐射发出的辐射的至少一部分 响应于所述照射采样以便产生对应于所述检测到的辐射的时间信号;以及分析模块，用于接收所述时间信号并且基于正向模型对所述信号执行统计分析以重建所述样本的图像。 / p>

公开(公告)号：WO2017188744A1

公开(公告)日：2017-11-02

申请号：PCT/KR2017/004474

申请日：2017-04-27

Applicant: 한국표준과학연구원

Inventor： 권혁상

IPC: G01N21/552 ,  G01Q60/04 ,  G01N21/25

CPC classification number: G01N21/658 ,  G01N21/255 ,  G01N2201/06113 ,  G01N2201/12

Abstract: 본 발명은 a) 암시야 현미경을 통해 SERS 센서용 기판 상에 위치한 나노입자의 색상을 측정하는 단계; b) 측정된 색상을 나노입자간 거리로 환산하는 단계; c) SERS 센서용 기판의 라만 신호강도를 획득하는 단계; d) 환산된 거리와 동일한 거리를 가지는 나노입자를 포함하는 표준 SERS 센서용 기판의 표준 라만 신호강도를 획득하는 단계; 및 e) 라만 신호강도와 표준 라만 신호강도를 비교하는 단계;를 포함하는 SERS 센서용 기판의 평가방법에 관한 것이다.

Abstract translation:

本发明包括以下步骤：a）测量所述纳米颗粒对于位于通过暗视野显微术在基片上SERS传感器的颜色; b）将测量的颜色转换成纳米颗粒距离; c）获得SERS传感器的衬底的拉曼信号强度; d）获得标准SERS传感器的衬底的标准拉曼信号强度，所述标准SERS传感器包括具有等于转换距离的距离的纳米粒子; e）将拉曼信号强度与标准拉曼信号强度进行比较。

公开(公告)号：WO2017174041A1

公开(公告)日：2017-10-12

申请号：PCT/CN2017/085410

申请日：2017-05-22

Applicant: 深圳市瀚海基因生物科技有限公司

Inventor： 颜钦 ,  姜泽飞 ,  郑焦 ,  吴平 ,  周志良 ,  葛良进

IPC: C12M1/34 ,  G01N21/64

CPC classification number: C12Q1/6869 ,  B01L3/502 ,  B01L9/50 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/18 ,  C12M1/34 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6471 ,  G01N2201/06113 ,  G01N2201/068 ,  G02B21/06 ,  G02B21/16 ,  G02B21/245 ,  C12Q2565/601

Abstract: 一种核酸测序系统，属于基因测序领域，其包括机座(1)，机座(1)上设有夹装平台(2)、试剂存放装置(3)、流体控制装置(4)、移动平台(5)和全反射显微镜(7)；夹装平台(2)上设有基因测序芯片(6)；试剂存放装置(3)用于存放基因测序试剂；流体控制装置(4)用于将基因测序试剂从试剂存放装置(3)内抽送至基因测序芯片(6)；移动平台(5)用于带动夹装平台(2)移向和移离全反射显微镜(7)；全反射显微镜(7)用于检测基因测序芯片(6)内的样品的基因序列。

公开(公告)号：WO2017173330A1

公开(公告)日：2017-10-05

申请号：PCT/US2017/025474

申请日：2017-03-31

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

Inventor： XIANG, Liangzhong ,  CHEN, Jian ,  SAMANT, Pratik

IPC: A61B8/13 ,  A61B5/06 ,  A61B6/03 ,  A61B6/12 ,  G01N21/00

CPC classification number: G01N29/0672 ,  A61B5/0095 ,  A61B5/02007 ,  A61B8/13 ,  A61B2562/0285 ,  G01N21/1702 ,  G01N29/221 ,  G01N29/223 ,  G01N29/2418 ,  G01N2021/1706 ,  G01N2201/06113 ,  G01N2291/02466

Abstract: A method and system of nanoscale photoacoustic tomography (nPAT) for non-invasive three-dimensional mapping and characterization of fine cellular structures (such as but not limited to organelles, vesicles, and macromolecules) of biological samples is disclosed.

Abstract translation: 纳米级光声层析成像（nPAT）的方法和系统，用于生物样品的细胞结构（例如但不限于细胞器，囊泡和大分子）的无创三维测绘和表征 被披露。

公开(公告)号：WO2017139719A1

公开(公告)日：2017-08-17

申请号：PCT/US2017/017579

申请日：2017-02-12

Applicant: BRETON, Leo

Inventor： BRETON, Leo

IPC: G01M15/10 ,  G01N21/35 ,  G01N33/00 ,  G01N15/04 ,  F01N13/00 ,  G01F1/46

CPC classification number: G01F1/46 ,  F01N11/00 ,  F01N2560/02 ,  F01N2560/07 ,  G01N21/27 ,  G01N21/3504 ,  G01N33/0036 ,  G01N2201/06113 ,  Y02T10/47

Abstract: A chemical species mass flow meter measurement system for use in fluid mixture streams includes a chemical species concentration detection analyzer physically located within a fluid volume flow rate sensing probe along with bulk temperature and pressure sensing devices for relating to standard conditions. The system uses concentration detection analyzers specifically suited to the intended application. Applications include the measurement of exhaust mass emissions from vehicles, the fuel economy of vehicles, as well as the measurement of the mass flow rate of chemical species of interest in general industrial processes.

Abstract translation: 用于流体混合物流中的化学物质质量流量计测量系统包括物理上位于流体体积流率感测探针内的化学物质浓度检测分析仪以及体温度和压力感测装置，用于与 标准条件。 该系统使用专门适用于预期应用的浓度检测分析仪。 其应用包括车辆尾气排放物测量，车辆的燃油经济性测量，以及一般工业过程中感兴趣的化学物质的质量流量测量。

公开(公告)号：WO2017098413A1

公开(公告)日：2017-06-15

申请号：PCT/IB2016/057401

申请日：2016-12-07

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  IBM UNITED KINGDOM LIMITED ,  IBM (CHINA) INVESTMENT COMPANY LIMITED

Inventor： LI, Ning ,  HU, Huan ,  SADANA, Devendra ,  ASTIER, Yann, Andre ,  SMITH, Joshua, Thomas ,  GUNAWAN, Oki ,  SPRATT, William, Thomas

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  B01L3/502753 ,  B01L2200/0652 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0864 ,  B01L2400/086 ,  G01N15/0255 ,  G01N15/1429 ,  G01N15/1436 ,  G01N15/1484 ,  G01N21/05 ,  G01N21/645 ,  G01N2015/0038 ,  G01N2015/0065 ,  G01N2015/035 ,  G01N2015/1081 ,  G01N2021/0346 ,  G01N2201/024 ,  G01N2201/06113 ,  G01N2201/062

Abstract: Methods, apparatuses, and computer program products are provided where fluid, such as a blood sample, is entered into a microfluidic channel (106, 108, 110, 202) in a microchip (102) where the microfluidic channel (106, 108, 110, 202) possesses a micro/nanopillar array (112, 208, 302) for sorting molecules (114, 116, 206, 210, 212, 304) by size. When the fluid passes through the micro/nanopillar array (112, 208, 302) it is separated into particles of interest (116, 210, 304) or particles not of interest (114, 212) or both. When particles of interest (116, 210, 304) are lit by a light source (120, 308) via a first waveguide (118, 306) in the microchip (102) connecting the light source (120, 308) to the microfluidic channel (106, 108, 110, 202), then lighted particles of interest (116, 210, 304) can be detected by an optical detector (124, 312) via a second waveguide (122, 310) in the microchip (102) connecting the optical detector (124, 312) to the microfluidic channel (106, 108, 110, 202). The information from the optical detector (124, 312) can be analyzed further by connecting the microchip (102) to a mobile computing device (104) with its own processing abilities or abilities via the internet or cloud (134).

Abstract translation: 提供了方法，装置和计算机程序产品，其中诸如血液样本的流体被输入到微芯片（102）中的微流体通道（106,108,110,202）中，其中 微流体通道（106,108,110,202）具有用于按大小分选分子（114,116,206,210,212,304）的微米/纳米柱阵列（112,208,302）。 当流体通过微米/纳米柱阵列（112,208,302）时，其被分离成感兴趣的颗粒（116,210,304）或不感兴趣的颗粒（114,212）或两者。 当通过微芯片（102）中的第一波导（118,306）将光源（120,308）连接到微流体通道（120,308）时，感兴趣的颗粒（116,210,304） （106,108,110,202），然后经由所述微芯片（102）中的第二波导（122,310）连接，由光学检测器（124,312）检测到所关注的发光粒子（116,210,304） 光学检测器（124,312）到微流体通道（106,108,110,202）。 来自光学检测器（124,312）的信息可通过经由因特网或云（134）以其自身处理能力或能力将微芯片（102）连接到移动计算设备（104）来进一步分析。

公开(公告)号：WO2017079462A1

公开(公告)日：2017-05-11

申请号：PCT/US2016/060370

申请日：2016-11-03

Applicant: COLORCULTURE NETWORK, LLC

Inventor： WITCHELL, David, J. ,  OLSON, Erlend

IPC: G06K9/00

CPC classification number: A45D44/005 ,  A45D2044/007 ,  A61B5/0075 ,  A61B5/448 ,  G01J3/2823 ,  G01N21/274 ,  G01N21/31 ,  G01N21/39 ,  G01N2201/06113 ,  G01N2201/127

Abstract: A method, system and device for determining the properties of hair and skin. The method, system and device facilitates the selection and application of an application of a product to the hair or skin of an individual to achieve a desired target result. The hair or skin properties measured may include the hair composition and chemical components of the hair, as well as substances that may coat the hair, and other substances on, absorbed or adsorbed on or into the hair. A hyper-spectral imaging component is employed to obtain information from the hair or skin and that information is used to provide a produce used to produce the target result.

Abstract translation: 用于确定头发和皮肤特性的方法，系统和设备。 该方法，系统和装置有利于产品对个人头发或皮肤的应用的选择和应用，以实现期望的目标结果。 测得的头发或皮肤特性可以包括头发的组成和化学成分，以及可能涂在头发上的物质，以及吸收或吸附在头发上或头发上的其他物质。 使用高光谱成像组件来从头发或皮肤获得信息，并且该信息被用于提供用于产生目标结果的产品。

公开(公告)号：WO2017075176A1

公开(公告)日：2017-05-04

申请号：PCT/US2016/059054

申请日：2016-10-27

Applicant: CEDARS-SINAI MEDICAL CENTER

Inventor： BLACK, Keith L. ,  BAKER, Michael ,  JONES, Howland ,  BUTTE, Pramod

IPC: G01N21/64 ,  A61B5/00 ,  G01J3/02 ,  G01J3/28 ,  G01J3/44

CPC classification number: A61B5/0071 ,  A61B5/00 ,  A61B5/0075 ,  A61B5/0091 ,  A61B5/08 ,  A61B5/4064 ,  A61B5/4255 ,  A61B5/441 ,  A61B5/7267 ,  A61B10/02 ,  A61B2017/00057 ,  A61B2576/026 ,  G01N21/6402 ,  G01N21/6408 ,  G01N2201/06113 ,  G01N2201/129 ,  G06K9/6267 ,  G06T7/0012 ,  G06T2207/10064 ,  G06T2207/30016 ,  G06T2207/30028 ,  G06T2207/30061 ,  G06T2207/30068 ,  G06T2207/30088

Abstract: Described herein are methods and systems for analyzing a sample by applying time resolved laser induced fluorescence spectroscopy to the sample to measure lifetime time decay profile data relating to the sample, and applying multivariate analysis to process the data so as to classify a sample as, for example, normal or abnormal. The sample may be cells, fluid or tissue from any organ. The sample may be in vitro or in vivo . The data may be obtained in situ or in vitro .

Abstract translation: 本文描述了用于通过将时间分辨激光诱导荧光光谱应用于样品以测量与样品有关的寿命时间衰减分布数据并且应用多变量分析来处理数据来分析样品的方法和系统 以将样品分类为例如正常或异常。 样品可以是来自任何器官的细胞，液体或组织。 样品可以是体外或体内。 数据可以在原位或体外。