公开(公告)号：WO1997005938A1

公开(公告)日：1997-02-20

申请号：PCT/US1996007717

申请日：1996-05-22

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  DENIEGA, Jose, C. ,  DUFF, Daniel, H.

IPC: B01D21/26

CPC classification number: A61M1/30 ,  A61M1/265 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M1/309 ,  A61M2205/3393 ,  A61M2209/082

Abstract: Blood separation systems and methods utilize a membrane separation device (52) comprising a gap (60) between a microporous membrane (64) and a surface (56) facing the microporous membrane (64), one of the microporous membranes (64) and the surface (56) being rotatable relative to the other to cause separation of whole blood in the gap (60) into plasma and concentrated red blood cells. The systems and methods include an inlet pump element (20) and a drive element (46) coupled to the membrane separation device (52) and the steps of commanding the inlet pump element (20) and the drive element (46) as a function of the known beginning hematocrit value to obtain concentrated red blood cells having a high end hematocrit value that remains substantially constant despite variances in the known beginning hematocrit value.

Abstract translation: 血液分离系统和方法利用膜分离装置（52），其包括在微多孔膜（64）和面向微孔膜（64）的表面（56）之间的间隙（60），微孔膜（64）和 表面（56）可相对于另一个旋转，以使间隙（60）中的全血分离成血浆和浓缩红细胞。 这些系统和方法包括入口泵元件（20）和联接到膜分离装置（52）的驱动元件（46），以及将入口泵元件（20）和驱动元件（46）命令为功能的步骤 的已知开始血细胞比容值以获得具有高端血细胞比容值的浓缩红细胞，其尽管在已知的开始血细胞比容值中存在差异但仍保持基本恒定。

公开(公告)号：WO99026678A1

公开(公告)日：1999-06-03

申请号：PCT/US1998/024010

申请日：1998-11-11

IPC: A61M1/34 ,  A61K35/14 ,  A61M1/02 ,  A61M1/26 ,  A61M1/30 ,  B01D17/02 ,  B01D21/00 ,  B01D21/24 ,  B01D21/26 ,  B01D21/28 ,  B01D21/30 ,  B01D61/00 ,  B01D61/14 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D61/08 ,  B01D61/22

CPC classification number: B01D21/2405 ,  A61M1/265 ,  A61M1/30 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M1/309 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3496 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3393 ,  A61M2209/082 ,  B01D17/0217 ,  B01D17/085 ,  B01D21/0012 ,  B01D21/26 ,  B01D2221/10

Abstract: Blood separation systems (200) and methods operate a pump (230) in the inlet line to convey a volume of whole blood from a donor (210) at a commanded flow rate for processing into plasma constituent (228) and concentrated red blood cells (204). The systems (200) and methods set the commanded flow rate to vary the volume of whole blood conveyed over time as a function of known hematocrit value of the selected donor (244), a targeted collection time (246) and a targeted volume of concentrated red blood cells (248). The systems and methods obtain, after processing of whole blood volume, a targeted volume of concentrated red blood cells, which is substantially constant for the population of blood donors despite variances in known hematocrit values among the donors.

Abstract translation: 血液分离系统（200）和方法操作入口管线中的泵（230），以指令的流速输送来自供体（210）的一定体积的全血以加工成血浆成分（228）和浓缩红细胞（ 204）。 系统（200）和方法设定所命令的流速以随着时间的推移改变输送的全血的体积，作为所选择的供体（244）的已知血细胞比容值的函数，靶向收集时间（246）和目标体积的浓缩 红细胞（248）。 系统和方法在全血容量处理后获得目标体积的浓缩红细胞，尽管献血者中已知血细胞比容值的差异，血液供体群体基本上是恒定的。

公开(公告)号：WO2008125893A1

公开(公告)日：2008-10-23

申请号：PCT/IB2007/000944

申请日：2007-04-12

Applicant: GAMBRO LUNDIA AB ,  FAVA, Massimo ,  SUFFRITTI, Mauro ,  SCAGLIONE, Alessandro

Inventor： FAVA, Massimo ,  SUFFRITTI, Mauro ,  SCAGLIONE, Alessandro

IPC: A61M1/16 ,  A61M1/34 ,  A61M1/36

CPC classification number: A61M1/3621 ,  A61M1/1627 ,  A61M1/1656 ,  A61M1/1662 ,  A61M1/1664 ,  A61M1/1682 ,  A61M1/1686 ,  A61M1/169 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/309 ,  A61M1/3465 ,  A61M1/3626 ,  A61M1/3629 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3647 ,  A61M1/3649 ,  A61M1/365 ,  A61M2205/3331 ,  A61M2205/6018 ,  A61M2205/6072

Abstract: A method and apparatus for priming an extracorporeal blood circuit, in which the patient end of an arterial line (79) is connected to a first discharge port (61), and the patient end of a venous line (87) is connected to a second discharge port (62). The two discharge ports are connected to a used dialysate line which connects a dialyser (33) to a drain. The arterial and venous lines are filled with a priming fluid, while the air contained in the arterial and venous lines is evacuated partly through the first discharge port and partly through the second discharge port. Two check valves (65, 66) prevent flow from the used dialysate line towards the two discharge ports. The invention reduces the risk of errors on the part of an operator readying the priming configuration, as well as the risk of contamination of the extracorporeal circuit during the priming phase.

Abstract translation: 一种用于引发体外血液回路的方法和装置，其中动脉线（79）的患者端连接到第一排出口（61），静脉管路（87）的患者端连接到第二 排出口（62）。 两个排出口连接到将透析器（33）连接到排水管的用过的透析液管线上。 动脉和静脉管线填充有引发液，而包含在动脉和静脉线中的空气部分地通过第一排出口排出，部分地通过第二排出口排出。 两个止回阀（65,66）防止从使用过的透析液流向两个排放口流出。 本发明降低了操作者准备启动配置的错误风险，以及在启动阶段期间体外电路污染的风险。

公开(公告)号：WO1990006781A1

公开(公告)日：1990-06-28

申请号：PCT/GB1989001486

申请日：1989-12-13

Applicant: BIO-FLO LIMITED ,  HOOD, Robert, Gordon

Inventor： BIO-FLO LIMITED

IPC: A61M01/14

CPC classification number: A61M1/3663 ,  A61M1/30 ,  A61M1/306 ,  A61M1/309 ,  A61M2205/12 ,  A61M2205/128

Abstract: A fluid flow control apparatus for use in separation and filtration is described which has a removable sterilisable/disposable element (27) which is engageable with a fixed portion (26). When engaged the flow of fluid around a fluid circuit is controlled to optimise separation. The removable element (27) may be combined with a filter unit (16) to form a unitary disposable cassette (90). Sensors (38, 40; 165, 167) can be incorporated in the apparatus for measuring fluid parameters such as pressure, viscosity and pH. Pressure sensors (165, 167; 226, 228) disposed at the filter inlet and outlet, are used to control the transmembrane pressure (TMP) to optimise filtration or separation and in one application this is used in controlling donor plasma separation.

Abstract translation: 描述了用于分离和过滤的流体流动控制装置，其具有可移除的可灭菌/一次性元件（27），其可与固定部分（26）接合。 当接合流体回路周围的流体流动被控制以优化分离。 可移除元件（27）可以与过滤器单元（16）组合以形成整体的一次性盒（90）。 传感器（38,40; 165,167）可以结合在用于测量诸如压力，粘度和pH的流体参数的装置中。 设置在过滤器入口和出口处的压力传感器（165,167,226,228）用于控制跨膜压力（TMP）以优化过滤或分离，并且在一个应用中，其用于控制​​供体血浆分离。