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    A MATERIAL USED FOR PHOSPHOPEPTIDE ENRICHMENT AND A PRODUCTION METHOD THEREOF
    1.
    发明申请
    A MATERIAL USED FOR PHOSPHOPEPTIDE ENRICHMENT AND A PRODUCTION METHOD THEREOF 审中-公开
    用于磷酸盐增殖的材料及其生产方法

    公开(公告)号：WO2014041513A1

    公开(公告)日：2014-03-20

    申请号：PCT/IB2013/058524

    申请日：2013-09-13

    Applicant: SALIH, Bekir ,  CELIKBICAK, Omur ,  ATAKAY, Mehmet

    Inventor： SALIH, Bekir ,  CELIKBICAK, Omur ,  ATAKAY, Mehmet

    IPC: G01N1/40 ,  B01J20/10 ,  B01J20/283 ,  B01J20/32

    CPC classification number: B01J20/3085 ,  B01J20/103 ,  B01J20/3204 ,  B01J20/3248 ,  B01J2220/64 ,  C07K1/145

    Abstract: The present invention relates to a material used for phosphopeptide enrichment which are employed in diagnosis of several diseases in medicine, and a production method thereof comprising the steps of preparing the solvent mixture (11), adjusting the solvent temperature (12), dissolving precursor in the solvent mixture (13), dissolving another precursor in the solvent mixture (14), adding acid into the mixture (15), stirring the mixture (16), filtering the mixture (17), washing off the obtained solid material (18), drying the obtained material (19).

    Abstract translation: 本发明涉及用于诊断医学中几种疾病的磷酸肽富集的材料及其制备方法，其包括以下步骤：制备溶剂混合物（11），调节溶剂温度（12），将前体溶解于 溶剂混合物（13），将另一种前体溶解在溶剂混合物（14）中，向混合物（15）中加入酸，搅拌混合物（16），过滤混合物（17），洗涤所获得的固体材料（18） ，干燥得到的材料（19）。

    METHODS, COMPOSITIONS, DEVICES, AND KITS FOR PERFORMING PHOSPHOLIPID SEPARATION
    2.
    发明申请
    METHODS, COMPOSITIONS, DEVICES, AND KITS FOR PERFORMING PHOSPHOLIPID SEPARATION 审中-公开
    用于进行磷脂分离的方法，组合物，装置和工具

    公开(公告)号：WO2011146890A1

    公开(公告)日：2011-11-24

    申请号：PCT/US2011/037438

    申请日：2011-05-20

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  IRANETA, Pamela, C. ,  WALTER, Thomas, H. ,  ZHANG, Xin ,  WALSH, Daniel, P. ,  WYNDHAM, Kevin, D. ,  FISK, Raymond, P.

    Inventor： IRANETA, Pamela, C. ,  WALTER, Thomas, H. ,  ZHANG, Xin ,  WALSH, Daniel, P. ,  WYNDHAM, Kevin, D. ,  FISK, Raymond, P.

    IPC: C07F9/02

    CPC classification number: C07F9/103 ,  B01D15/22 ,  B01D15/327 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28061 ,  B01J20/28069 ,  B01J20/287 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3246 ,  B01J20/3293 ,  B01J2220/64 ,  B01L3/5023 ,  B01L3/50255 ,  B01L2300/0681 ,  C07K1/30 ,  G01N2030/8813

    Abstract: Methods, kits and devices for separating phospholipids and proteins from small molecules in biochemical samples can feature an apparatus having a wetting barrier, at least one frit and a separation media. For example, an apparatus can include at least one wall defining a chamber having an exit and an entrance; a wetting barrier disposed between the exit and entrance, so as to define a separation media space located between the wetting barrier and the exit and a sample receiving area located between the wetting barrier and the entrance; and a separation media disposed adjacent to the wetting barrier and having a specific affinity for phospholipids. The wetting barrier is adapted to (i) retain the liquid sample and a protein precipitating agent in the sample receiving area under a first force, thereby facilitating the formation of a protein precipitate and a processed sample, and (ii) flow the processed sample through the wetting barrier and separation media under a second force, wherein the second force is greater than the first force, thereby retaining the protein precipitate in the sample receiving area, retaining phospholipids in the separation media, and eluting small molecules.

    Abstract translation: 用于从生物化学样品中分离磷脂和蛋白质与小分子的方法，试剂盒和装置可以具有具有润湿屏障的装置，至少一个玻璃料和分离介质。 例如，设备可以包括限定具有出口和入口的室的至少一个壁; 设置在出口和入口之间的润湿屏障，以便限定位于润湿屏障和出口之间的分离介质空间和位于润湿屏障和入口之间的样品接收区域; 以及与所述润湿屏障相邻并且对磷脂具有特异性亲和力的分离介质。 润湿屏障适于（i）在第一力下在样品接收区域中保留液体样品和蛋白质沉淀剂，从而有助于蛋白质沉淀物和加工样品的形成，以及（ii）将经处理的样品通过 润湿屏障和分离介质，其中第二力大于第一力，从而将蛋白质沉淀物保留在样品接收区域中，将磷脂保留在分离介质中，并洗脱小分子。

    CO-SINTERED POLYMER STRUCTURES
    3.
    发明申请
    CO-SINTERED POLYMER STRUCTURES 审中-公开
    共烧聚合物结构

    公开(公告)号：WO2008029115A1

    公开(公告)日：2008-03-13

    申请号：PCT/GB2007/003327

    申请日：2007-09-04

    Applicant: PORVAIR FILTRATION GROUP LIMITED ,  COWIESON, David, Richard

    Inventor： COWIESON, David, Richard

    IPC: G01N1/34 ,  B01D15/20 ,  B01D15/26 ,  B01J20/26

    CPC classification number: C08J9/24 ,  B01J20/26 ,  B01J20/268 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28026 ,  B01J20/28052 ,  B01J20/28054 ,  B01J2220/64

    Abstract: A co-sintered porous polymer includes at least one molecule specific powder for adsorbing at least one target molecule from a complex liquid mixture when the liquid is passed through the porous co-sintered polymer. The co-sintered polymer can include a sintered porous polyethylene substrate. The or each molecule specific powder can be an immobilising adsorbent powder, for example a molecularly imprinted polymer or a rationally designed polymer.

    Abstract translation: 共烧结多孔聚合物包括至少一种分子特异性粉末，用于当液体通过多孔共烧结聚合物时从复合液体混合物中吸附至少一种靶分子。 共烧结聚合物可以包括烧结多孔聚乙烯基材。 所述或每种分子特异性粉末可以是固定的吸附剂粉末，例如分子印迹聚合物或合理设计的聚合物。

    DEVICE AND METHOD FOR COLLECTING, TRANSPORTING AND RECOVERING LOW MOLECULAR WEIGHT ANALYTES IN SALIVA
    6.
    发明申请
    DEVICE AND METHOD FOR COLLECTING, TRANSPORTING AND RECOVERING LOW MOLECULAR WEIGHT ANALYTES IN SALIVA 审中-公开
    收集，运输和恢复萨拉利昂低分子量分析仪的装置和方法

    公开(公告)号：WO2003007814A1

    公开(公告)日：2003-01-30

    申请号：PCT/US2002/022843

    申请日：2002-07-18

    Applicant: AGILEX BIOSCIENCES, INC. ,  PRONOVOST, Allan, D.

    Inventor： PRONOVOST, Allan, D.

    IPC: A61B5/00

    CPC classification number: B01J20/20 ,  A61B10/0051 ,  B01D15/34 ,  B01J20/18 ,  B01J20/24 ,  B01J20/26 ,  B01J2220/64 ,  G01N1/405 ,  G01N30/02

    Abstract: This invention relates to low molecular weight analyte sequestration, storage, transport and recovery device and methods for its use with saliva samples in the detection of glucose and other low molecular weight analytes. A stimulated or non-stimulated saliva sample is contacted with a matrix (16) disposed within a container (12) that adsorbs glucose, absorbs water and excludes molecules above a certain size when hydrated. After hydration of the matrix by the saliva sample, the glucose is both adsorbed to the matrix, and migrates into the cavities within the matrix, whereas microbes such as bacteria and larger molecules such as proteins cannot. A membrane (18) keeps the matrix (16) in the bottom of the container (12). The sample is then transported to a location where the glucose will be eluted from the matrix and assayed.

    Abstract translation: 本发明涉及低分子量分析物隔离，储存，运输和回收装置及其在唾液样品中用于检测葡萄糖和其它低分子量分析物的方法。 将受刺激或未刺激的唾液样品与位于容器（12）内的基质（16）接触，所述容器（12）在水合时吸附葡萄糖，吸收水并排除高于某一尺寸的分子。 在通过唾液样品对基质进行水合之后，葡萄糖都被吸附到基质上，并且迁移到基质内的空腔中，而微生物如细菌和较大分子如蛋白质则不能。 膜（18）将基质（16）保持在容器（12）的底部。 然后将样品运送到葡萄糖将从基质中洗脱出来并测定的位置。

    AN INTEGRATED HIGH THROUGHPUT SYSTEM FOR THE ANALYSIS OF BIOMOLECULES
    7.
    发明申请
    AN INTEGRATED HIGH THROUGHPUT SYSTEM FOR THE ANALYSIS OF BIOMOLECULES 审中-公开
    用于分析生物分子的综合高通量系统

    公开(公告)号：WO2002082051A2

    公开(公告)日：2002-10-17

    申请号：PCT/US2002/001541

    申请日：2002-01-15

    Applicant: TUBBS, Kemmons, A.

    Inventor： TUBBS, Kemmons, A. ,  NELSON, Randall, W. ,  GRUBER, Karl, A.

    IPC: G01N

    CPC classification number: G01N33/6845 ,  B01J20/28097 ,  B01J20/281 ,  B01J20/286 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3242 ,  B01J20/3259 ,  B01J20/3265 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3282 ,  B01J2220/54 ,  B01J2220/64 ,  B82Y30/00 ,  G01N30/02 ,  G01N30/48 ,  G01N30/6095 ,  G01N33/54366 ,  G01N33/545 ,  G01N33/6803 ,  G01N2570/00 ,  H01J49/164 ,  H01J49/40 ,  Y10T436/255 ,  B01D15/3804

    Abstract: The present invention provides an integrated system capable of selectively retrieving and concentrating specific biomolecules from biological media for subsequent high-performance analyses, quantifying targeted proteins, recognizing variants of targeted biomolecules (e.g., splice variants, point mutations and posttranslational modifications) and elucidating their nature, analyzing for, and identifying, ligands interacting with targeted biomolecules, and high-throughput screening of large populations of samples using a single, unified, economical, multiplexed and parallel processing platform. The prefer-red embodiment of the integrated system comprises molecular traps, such as affinity microcolumns, derivatized mass spectrometer targets, mass spectrometers capable of multi-sample input and robotics with processing/data analysis interactive database. The present invention also includes methods and processes for use of the individual components and the integrated system in biological applications. Furthermore, the preferred embodiment of the present invention provides for the preparation and/or processing of multiple separate devices and/or samples to accomplish high throughput analysis.

    Abstract translation: 本发明提供了能够选择性地从生物培养基中回收和浓缩特定生物分子以进行后续高效分析，定量靶向蛋白质，识别靶向生物分子变异（例如，剪接变体，点突变和翻译后修饰）并阐明其性质的整合系统 ，分析和鉴定与靶向生物分子相互作用的配体，以及使用单个，统一，经济，多路复用和并行处理平台的大量样品的高通量筛选。 集成系统的优选实施例包括分子阱，例如亲和力微柱，衍生质谱仪目标，能够进行多样本输入的质谱仪和具有处理/数据分析交互式数据库的机器人。 本发明还包括在生物应用中使用各个部件和集成系统的方法和方法。 此外，本发明的优选实施例提供了用于实现高通量分析的多个分离的装置和/或样品的制备和/或处理。

    SAMPLE PREPARATION DEVICE WITH EMBEDDED SEPARATION MEDIA
    9.
    发明申请
    SAMPLE PREPARATION DEVICE WITH EMBEDDED SEPARATION MEDIA 审中-公开
    具有嵌入式分离介质的样品制备装置

    公开(公告)号：WO02040131A1

    公开(公告)日：2002-05-23

    申请号：PCT/US2001/050151

    申请日：2001-10-26

    IPC: B01J20/28 ,  B01L3/02 ,  G01N1/40 ,  G01N30/60 ,  B01D15/08

    CPC classification number: B01J20/28026 ,  B01J2220/64 ,  B01L3/0275 ,  B01L2200/0631 ,  G01N1/405 ,  G01N30/6004 ,  G01N30/6039 ,  G01N30/606 ,  G01N30/6065 ,  G01N30/6069

    Abstract: The present invention relates to a device for small volume sample preparation using tubes (1), columns, and sheets, such as capillaries or pipette tips, in which particles of a separation medium (4), such as particles of a chromatography material used for sample preparation, are directly embedded in the solid material composing the tubes (1) or columns or sheets. The present invention minimizes sample loss and is well suited for samples with volumes in nanoliters.

    Abstract translation: 本发明涉及一种使用管（1），柱和片材（例如毛细管或吸管头）的小体积样品制备装置，其中分离介质（4）的颗粒例如用于 样品制备物直接嵌入构成管（1）或柱或片的固体材料中。 本发明使样品损失最小化，并且非常适合具有纳升体积的样品。

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