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    CONFORMATIONALLY RESTRICTED POLYAMINES AND THEIR USE AS ANTINEOPLASTIC AGENTS
    2.
    发明申请
    CONFORMATIONALLY RESTRICTED POLYAMINES AND THEIR USE AS ANTINEOPLASTIC AGENTS 审中-公开
    一致的限制性聚氨酯及其作为抗肿瘤药物使用

    公开(公告)号：WO1998017624A1

    公开(公告)日：1998-04-30

    申请号：PCT/US1997018453

    申请日：1997-10-15

    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION

    Inventor： WISCONSIN ALUMNI RESEARCH FOUNDATION ,  FRYDMAN, Benjamin, J. ,  MARTON, Laurence, J. ,  REDDY, Vendohar, K. ,  VALASINAS, Aldonia, L. ,  WITIAK, Donald, T.

    IPC: C07C211/18

    CPC classification number: C07C211/36 ,  C07C211/18 ,  C07C211/22

    Abstract: Compounds of the Formula (I): E-NH-D-NH-B-A-B-NH-D-NH-E, wherein A is C2-C6 alkene, C3-C6 cycloalkyl, cycloalkenyl, or cycloaryl; B is independently a single bond, C1-C6 alkyl alkenyl; D is independently C1-C6 alkyl or alkenyl, or C3-C6 cycloalkyl, cycloalkenyl, or cycloaryl; and E is independently H, C1-C6 alkyl or alkenyl; and pharmaceutically suitable salts thereof; a synthetic method therefor, pharmaceutical dosage forms containing one of more of these compounds, and use of these compounds in the treatment of neoplastic cell growth, are disclosed.

    Abstract translation: 式（I）化合物：E-NH-D-NH-B-A-B-NH-D-NH-E，其中A是C 2 -C 6烯烃，C 3 -C 6环烷基，环烯基或环芳基; B独立地是单键，C1-C6烷基烯基; D独立地为C 1 -C 6烷基或链烯基，或C 3 -C 6环烷基，环烯基或环芳基; 且E独立地为H，C 1 -C 6烷基或链烯基; 和其药学上合适的盐; 公开了其合成方法，含有这些化合物中的一种以上的药物剂型以及这些化合物在治疗肿瘤细胞生长中的用途。

    ANTIFUNGAL COMPOUNDS
    9.
    发明申请
    ANTIFUNGAL COMPOUNDS 审中-公开
    抗真菌化合物

    公开(公告)号：WO1992021236A1

    公开(公告)日：1992-12-10

    申请号：PCT/GB1992000964

    申请日：1992-05-28

    Applicant: BRITISH TECHNOLOGY GROUP LTD. ,  ROBINS, David, John ,  WALTERS, Dale, Ronald

    Inventor： BRITISH TECHNOLOGY GROUP LTD.

    IPC: A01N33/04

    CPC classification number: A01N33/04 ,  C07C211/22

    Abstract: Compounds having the formula (I): (R1R2N)CH2-CH=CH-CH2(NR3R4) wherein R1, R2, R3 and R4, which may be the same or different represent hydrogen atoms, an alkyl group having from 1 to 6 carbon atoms, a cycloalkyl group of 3 to 6 carbon atoms, a heterocyclic group, an aryl group, a heteroaryl group having from 3 to 6 atoms, an amidino group or R1, R2 and/or R3 and R4 together represent a carbocyclic or heterocyclic group comprising from 3 to 6 atoms with the proviso that R1, R2, R3 and R4 cannot simultaneously represent hydrogen and salts thereof are fungicides especially mildewicides. Preferred compounds are those wherein the groups R represent methyl or ethyl groups.

    Abstract translation: 具有式（I）的化合物：（R 1 R 2 N）CH 2 -CH = CH-CH 2（NR 3 R 4）其中可以相同或不同的R 1，R 2，R 3和R 4表示氢原子，具有1至6个碳原子的烷基 3至6个碳原子的环烷基，杂环基，芳基，3至6个原子的杂芳基，脒基或R 1，R 2和/或R 3和R 4一起表示碳环或杂环基 包括3至6个原子，条件是R1，R2，R3和R4不能同时代表氢，其盐是杀真菌剂，特别是防霉剂。 优选的化合物是其中基团R表示甲基或乙基的化合物。

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