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    REGULATORY NUCLEIC ACIDS AND METHODS OF USE
    1.
    发明申请
    REGULATORY NUCLEIC ACIDS AND METHODS OF USE 审中-公开
    调节性核酸和使用方法

    公开(公告)号：WO2013067259A3

    公开(公告)日：2013-08-15

    申请号：PCT/US2012063169

    申请日：2012-11-02

    Applicant: SYNGENTA PARTICIPATIONS AG ,  NUCCIO MICHAEL

    Inventor： NUCCIO MICHAEL

    IPC: C12N15/82 ,  A01H5/00 ,  C12N9/00 ,  C12N9/12 ,  C12N9/16 ,  C12N9/88

    CPC classification number: C12N15/8269 ,  C12N9/0006 ,  C12N9/1205 ,  C12N9/1294 ,  C12N9/16 ,  C12N9/88

    Abstract: The present invention relates generally to the field of molecular biology and describes nucleic acids encoding regulatory elements capable of affecting expression of a coding sequence. The regulatory elements described herein may be used to direct the expression of a heterologous coding region in the green tissues and upon exposure to light in plants. The invention may also be used to create transgenic plants having increased yield.

    Abstract translation: 本发明一般涉及分子生物学领域，并且描述了编码能够影响编码序列表达的调控元件的核酸。 本文所述的调节元件可用于指导在绿色组织中的异源编码区的表达和在植物中暴露于光时。 本发明还可用于产生具有增加的产量的转基因植物。

    PLANTS WITH REDUCED ACTIVITY OF THE STARCH PHOSPHORYLATING ENZYME PHOSPHOGLUCAN, WATER DIKINASE
    2.
    发明申请
    PLANTS WITH REDUCED ACTIVITY OF THE STARCH PHOSPHORYLATING ENZYME PHOSPHOGLUCAN, WATER DIKINASE 审中-公开
    具有降低活性的植物酶活性磷酸酶水解酶

    公开(公告)号：WO2005095618A3

    公开(公告)日：2006-03-02

    申请号：PCT/EP2005002450

    申请日：2005-03-04

    Applicant: BAYER CROPSCIENCE GMBH ,  FROHBERG CLAUS ,  KOETTING OLIVER ,  RITTE GERHARD ,  STEUP MARTIN

    Inventor： FROHBERG CLAUS ,  KOETTING OLIVER ,  RITTE GERHARD ,  STEUP MARTIN

    IPC: C12N9/00 ,  C12N9/12 ,  C12N15/82 ,  A01H5/00 ,  C07K16/40 ,  C12N1/21 ,  C12N5/10 ,  C12N15/01 ,  C12N15/11 ,  C12N15/54

    CPC classification number: C12N9/00 ,  C08B31/066 ,  C12N9/1294 ,  C12N15/8245

    Abstract: The present invention relates to plant cells and plants, which are genetically modified, wherein the genetic modification leads to the reduction of the activity of a starch phosphorylating OKl protein in comparison with corresponding wild type plant cells or wild type plants that have not been genetically modified. The OKl protein acts as a phosphoglucan, water dikinase (PWD) which predominately phosphorylates the C3 position. Genetically modified plants in which the expression of PWD is reduced show a starch excess phenotype. Furthermore, the present invention relates to means and methods for the manufacture of such plant cells and plants. Plant cells and plants of this type synthesise a modified starch. The present invention therefore also relates to the starch synthesised by the plant cells and plants according to the invention, methods for the manufacture of this starch, and the manufacture of starch derivatives of this modified starch, as well as flours containing starches according to the invention. Furthermore, the present invention relates to nucleic acid molecules, which ar suitable for manufacturing plants according to the invention.

    Abstract translation: 本发明涉及遗传修饰的植物细胞和植物，其中与相应的野生型植物细胞或未经遗传修饰的野生型植物相比，遗传修饰导致淀粉磷酸化OK1蛋白的活性降低 。 OK1蛋白作为主要磷酸化C3位置的磷酸葡聚糖，水分激酶（PWD）。 其中PWD表达减少的遗传修饰植物显示淀粉过量表型。 此外，本发明涉及用于制造这种植物细胞和植物的方法和方法。 这种植物细胞和植物合成改性淀粉。 因此，本发明还涉及由根据本发明的植物细胞和植物合成的淀粉，这种淀粉的制造方法，以及该改性淀粉的淀粉衍生物的制造，以及含有本发明淀粉的面粉 。 此外，本发明涉及适合于制造根据本发明的植物的核酸分子。

    REGULATORY NUCLEIC ACIDS AND METHODS OF USE
    4.
    发明申请
    REGULATORY NUCLEIC ACIDS AND METHODS OF USE 审中-公开
    调节核酸及其使用方法

    公开(公告)号：WO2013067259A2

    公开(公告)日：2013-05-10

    申请号：PCT/US2012/063169

    申请日：2012-11-02

    Applicant: SYNGENTA PARTICIPATIONS AG ,  NUCCIO, Michael

    Inventor： NUCCIO, Michael

    IPC: C12N15/82 ,  C12N9/12 ,  A01H5/00 ,  C12N9/16 ,  C12N9/88 ,  C12N9/00

    CPC classification number: C12N15/8269 ,  C12N9/0006 ,  C12N9/1205 ,  C12N9/1294 ,  C12N9/16 ,  C12N9/88

    Abstract: The present invention relates generally to the field of molecular biology and describes nucleic acids encoding regulatory elements capable of affecting expression of a coding sequence. The regulatory elements described herein may be used to direct the expression of a heterologous coding region in the green tissues and upon exposure to light in plants. The invention may also be used to create transgenic plants having increased yield.

    Abstract translation: 本发明一般涉及分子生物学领域，并且描述了编码能够影响编码序列表达的调节元件的核酸。 本文所述的调节元件可用于指导绿色组织中异源编码区的表达并且在植物中暴露于光下时。 本发明还可以用于产生具有增加产量的转基因植物。

    WNT PATHWAY MUTATIONS IN CANCER STEM CELLS
    6.
    发明申请
    WNT PATHWAY MUTATIONS IN CANCER STEM CELLS 审中-公开
    癌症干细胞中的WNT途径突变

    公开(公告)号：WO2008073619A2

    公开(公告)日：2008-06-19

    申请号：PCT/US2007083532

    申请日：2007-11-02

    Applicant: UNIV CALIFORNIA ,  JAMIESON CATRIONA HELEN M ,  GERON IFAT ,  ABRAHAMSON ANNELIE ,  KAVALERCHIK EDWARD ,  WEISSMAN IRVING L ,  GOTTLIB JASON

    Inventor： JAMIESON CATRIONA HELEN M ,  GERON IFAT ,  ABRAHAMSON ANNELIE ,  KAVALERCHIK EDWARD ,  WEISSMAN IRVING L ,  GOTTLIB JASON

    IPC: C12Q1/68

    CPC classification number: C12N9/1294 ,  A01K67/0271 ,  A01K2227/105 ,  A01K2267/0331 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136

    Abstract: Cancer specific splicing events in the Wnt/ß -catenin signaling pathway are associated with progression of myelogenous leukemia. Misspliced genes of interest include GSK3ß. In some embodiments of the invention, polynucleotides are provided that correspond to misspliced GSK3ß transcripts associated with cancer. Such transcripts are characterized by a deletion of exon (8), and particularly in exon (8) and (9). Detection of such transcripts in cells is indicative of the presence of leukemia, and particularly of the presence of leukemia stem cells. In other embodiments, polypeptides are provided that are encoded by misspliced GSK3ß transcripts associated with cancer. Such polypeptides are useful as diagnostic markers for cancer, and as a target for screening of therapeutic agents. Animal models comprising a human LSC having a misspliced GSK3b transcript provide a useful model for leukemia, for drug/gene screening in the prevention and treatment of leukemia in humans, etc.

    Abstract translation: Wnt /β-catenin信号通路中的癌细胞特异性剪接事件与骨髓性白血病的进展有关。 感兴趣的未知基因包括GSK3β。 在本发明的一些实施方案中，提供了与癌症相关的错过的GSK3β转录物相应的多核苷酸。 这些转录物的特征在于外显子（8）的缺失，特别是在外显子（8）和（9）中。 细胞中这些转录物的检测表明存在白血病，特别是存在白血病干细胞。 在其它实施方案中，提供由与癌症相关的错过的GSK3β转录物编码的多肽。 这样的多肽可用作癌症的诊断标记物，以及用作筛选治疗剂的靶标。 包含具有错误的GSK3b转录物的人LSC的动物模型为白血病提供了有用的模型，用于预防和治疗人类白血病等的药物/基因筛选。

    GENETICALLY MODIFIED PLANTS WHICH SYNTHESIZE A STARCH HAVING INCREASED SWELLING POWER
    7.
    发明申请
    GENETICALLY MODIFIED PLANTS WHICH SYNTHESIZE A STARCH HAVING INCREASED SWELLING POWER 审中-公开
    合成改良植物的遗传改良植物

    公开(公告)号：WO2008017518A1

    公开(公告)日：2008-02-14

    申请号：PCT/EP2007/007282

    申请日：2007-08-09

    Applicant: BAYER CROPSCIENCE AG ,  FROHBERG, Claus

    Inventor： FROHBERG, Claus

    IPC: C12N5/10 ,  C12N15/29 ,  A01H5/00 ,  C08B30/04 ,  A23L1/0522 ,  C12N9/12 ,  C12N9/10

    CPC classification number: C12N15/8245 ,  C08B30/04 ,  C08B30/042 ,  C08B30/044 ,  C08B31/00 ,  C12N9/1051 ,  C12N9/1294

    Abstract: The present invention relates to genetically modified plant cells and plants, and to processes for the production of genetically modified plant cells and plants which have an increased activity of a protein having the activity of a starch synthase Il and an increased activity of a protein having the activity of a glucan-water dikinase. Plants of this type synthesize starches having increased hot water swelling power. The present invention likewise relates to starches having increased hot water swelling power, and to processes for their production.

    Abstract translation: 本发明涉及遗传修饰的植物细胞和植物，以及用于生产具有增加的具有淀粉合成酶II活性的蛋白质的活性增加的遗传修饰的植物细胞和植物的方法，以及具有 葡聚糖 - 水二激酶的活性。 这种类型的植物合成具有增加的热水膨胀力的淀粉。 本发明同样涉及具有增加的热水膨胀力的淀粉及其生产方法。

    PLANTS WITH ENGINEERED ENDOGENOUS GENES
    8.
    发明申请
    PLANTS WITH ENGINEERED ENDOGENOUS GENES 审中-公开
    具有工程内源基因的植物

    公开(公告)号：WO2016054039A1

    公开(公告)日：2016-04-07

    申请号：PCT/US2015/052940

    申请日：2015-09-29

    Applicant: AGRIVIDA, INC.

    Inventor： RAAB, R. Michael ,  LANAHAN, Michael ,  BONIN, Christopher ,  BOUGRI, Oleg

    IPC: C12N15/82 ,  A23K10/00

    CPC classification number: C12N15/8245 ,  C12N9/1294 ,  C12N15/8218

    Abstract: Genetically engineered plants expressing altered Glucan Water Dikinase and having elevated levels of starch are provided. Methods of genetically engineering plants to express altered Glucan Water Dikinase, and genetic constructs are provided. Methods of breeding genetically engineered plants homozygous for a mutated gene encoding an altered Glucan Water Dikinase are described. Methods of agricultural processing and animal feed using the genetically engineered plants are also provided.

    Abstract translation: 提供表达改变的葡聚糖水定影素并具有升高的淀粉水平的转基因植物。 提供植物表达改变的葡聚糖水定点酶的方法和基因构建体。 描述了对编码改变的葡聚糖水定点酶的突变基因纯合的遗传工程植物的方法。 还提供了使用遗传工程植物的农业加工和动物饲料的方法。

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