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    OCCLUSION RESISTANT HYDROCEPHALIC SHUNT
    2.
    发明申请
    OCCLUSION RESISTANT HYDROCEPHALIC SHUNT 审中-公开
    防止水污染

    公开(公告)号：WO2004073768A2

    公开(公告)日：2004-09-02

    申请号：PCT/US2004004925

    申请日：2004-02-18

    Applicant: MEDTRONIC INC ,  KOULLICK EDOUARD ,  HENDRIKS MARC ,  BERTRAND WILLIAM J

    Inventor： KOULLICK EDOUARD ,  HENDRIKS MARC ,  BERTRAND WILLIAM J

    IPC: A61K9/50 ,  A61L31/06 ,  A61L31/16 ,  A61M20060101 ,  A61M5/00 ,  A61M27/00 ,  A61M29/00 ,  A61M

    CPC classification number: A61L31/16 ,  A61L31/06 ,  A61L2300/00 ,  A61M1/3655 ,  A61M27/006 ,  C08L83/04 ,  C08L75/04

    Abstract: An occlusion resistant medical shunt, particularly a hydrocephalic shunt, is provided for implantation into a mammal. The shunt has an elongate wall structure configured as a tube having a lumen therethrough and a proximal end for receipt of bodily fluids. The bodily fluids, such as cerebrospinal fluid, flows through the shunt to a distal end for discharge of the bodily fluids. The wall structure of the shunt generally includes a biocompatible medical device material. The shunts of the present invention further include one or more occlusion resistant materials to resist occlusion of the lumenal passage in the shunt.

    Abstract translation: 提供阻塞性医疗分路，特别是脑积水分流器，用于植入哺乳动物。 分流器具有细长的壁结构，其构造为具有通过其的内腔的管，以及用于接收体液的近端。 体液如脑脊液通过分流器流到远端以排出体液。 分流器的壁结构通常包括生物相容的医疗装置材料。 本发明的分流器还包括一种或多种抗阻塞材料，以阻止分路中的内腔通道的阻塞。

    MEDICAL DEVICES FOR DELIVERING ANTI-PROLIFERATIVE COMPOSITIONS TO ANATOMICAL SITES AT RISK FOR RESTENOSIS
    7.
    发明申请
    MEDICAL DEVICES FOR DELIVERING ANTI-PROLIFERATIVE COMPOSITIONS TO ANATOMICAL SITES AT RISK FOR RESTENOSIS 审中-公开
    用于递送抗增生组合物的医疗设备到存在风险的解剖学位点

    公开(公告)号：WO03079936A9

    公开(公告)日：2004-02-26

    申请号：PCT/US0308332

    申请日：2003-03-18

    Applicant: MEDTRONIC AVE INC ,  TREMBLE PATRICE ,  HENDRIKS MARC ,  CARLYLE WENDA

    Inventor： TREMBLE PATRICE ,  HENDRIKS MARC ,  CARLYLE WENDA

    IPC: A61F2/00 ,  A61F2/82 ,  A61K31/33 ,  A61F2/06

    CPC classification number: A61F2/82 ,  A61F2250/0067 ,  A61K31/33

    Abstract: Methods, compositions and devices for inhibiting restenosis are provided. Specifically, molecular chaperone inhibitor compositions and medical devices useful for the site specific delivery of molecular chaperones are disclosed. In one embodiment the medical device is a vascular stent coated with a molecular chaperone inhibitor selected from the group consisting of geldanamycin, herbimycin, macbecin and derivatives and analogues thereof. In another embodiment an injection catheter for delivery and an anti-restenotic effective amount of geldanamycin to the adventitia is provided.

    Abstract translation: 提供了用于抑制再狭窄的方法，组合物和装置。 具体地，公开了分子伴侣抑制剂组合物和用于分子伴侣的位点特异性递送的医疗装置。 在一个实施方案中，医疗装置是涂覆有分子伴侣抑制剂的血管支架，所述分子伴侣抑制剂选自格尔德霉素，草甘膦，麦芽酚及其衍生物和类似物。 在另一个实施方案中，提供用于递送的注射导管和抗再狭窄有效量的格尔德霉素至外膜。

    METHOD FOR MAKING HEPARINIZED BIOMATERIALS
    8.
    发明申请
    METHOD FOR MAKING HEPARINIZED BIOMATERIALS 审中-公开
    制备生物制剂的方法

    公开(公告)号：WO9707834A3

    公开(公告)日：1997-03-27

    申请号：PCT/US9612996

    申请日：1996-08-12

    Applicant: MEDTRONIC INC

    Inventor： VERHOEVEN MICHEL ,  CAHALAN LINDA L ,  HENDRIKS MARC ,  FOUACHE BENEDICTE ,  CAHALAN PATRICK T

    IPC: A61L33/10 ,  A61L33/00

    CPC classification number: A61L33/0011 ,  A61L33/0023 ,  A61L33/0029 ,  Y10S623/921

    Abstract: An improved method of making a medical device having immobilized heparin on a blood-contacting surface in which heparin is admixed with sufficient periodate to react with not more than two sugar units per heparin molecule in a buffer solution having a pH in the range of about 4.5-8. This mixture is reacted for at least 3 hours while protected from light and is then applied to the immobilized amine groups. This is an improvement over the prior art methods which included using an excess of periodate and then stopping the reaction at a desired point by the addition of glycerol since the conversion of only a few of the natural functional groups to aldehydes better preserves the antithrombotic bioeffectiveness of the heparin molecules bound to the surface. The invention also avoids the prior art steps of drying and reconstituting the heparin by providing a reacted mixture of heparin and periodate that can be stored as a stable liquid and applied directly to the aminated surface several days later.

    MEDICAL DEVICE AND METHODS OF USE
    10.
    发明申请
    MEDICAL DEVICE AND METHODS OF USE 审中-公开
    医疗器械及其使用方法

    公开(公告)号：WO02058752A9

    公开(公告)日：2003-02-06

    申请号：PCT/US0144435

    申请日：2001-11-27

    Applicant: MEDTRONIC INC

    Inventor： HENDRIKS MARC

    IPC: A61L27/34 ,  A61L27/38 ,  A61L27/54 ,  A61L29/00 ,  A61L29/08 ,  A61L29/16 ,  A61L31/00 ,  A61L31/14 ,  A61L31/16

    CPC classification number: A61L29/16 ,  A61L27/34 ,  A61L27/38 ,  A61L27/54 ,  A61L29/005 ,  A61L29/085 ,  A61L31/005 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/258 ,  A61L2300/404 ,  A61L2300/626 ,  A61L2300/64

    Abstract: The present invention provides a medical device that includes a carrier and a polynucleotide, where the carrier has a surface that includes a polymer with which the polynucleotide is associated. In another aspect, the present invention provides a medical device that includes a carrier and a cell that expresses an antimicrobial peptide, where the carrier has a surface that includes a polymer with which the cell is associated. The present invention further provides methods of making and using medical devices that include a carrier and a polynucleotide or a cell.0.

    Abstract translation: 本发明提供了一种包括载体和多核苷酸的医疗装置，其中载体具有包含与多核苷酸缔合的聚合物的表面。 另一方面，本发明提供一种医疗装置，其包括载体和表达抗微生物肽的细胞，其中所述载体具有包含与细胞结合的聚合物的表面。 本发明还提供制造和使用包括载体和多核苷酸或细胞的医疗器械的方法。

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