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    METHOD OF TREATING A FABRIC
    6.
    发明申请
    METHOD OF TREATING A FABRIC 审中-公开
    处理织物的方法

    公开(公告)号：WO2016176280A1

    公开(公告)日：2016-11-03

    申请号：PCT/US2016/029479

    申请日：2016-04-27

    申请人： THE PROCTER & GAMBLE COMPANY

    发明人： LANT, Neil, Joseph ,  WOOD, Rebecca, Louise ,  GUMEL, Jeremie, Robert Marcel

    IPC分类号： C11D3/386

    CPC分类号： C11D3/38636 ,  C12Y301/21001 ,  C12Y301/30002 ,  C12Y302/01052

    摘要： Method for treating a hydrophobically-modified textile with an aqueous solution of a nuclease enzyme, preferably a deoxyribonuclease or ribonuclease enzyme, rinsing and drying the textile. Use of the finishing step for improved cleaning with an aqueous solution of a nuclease enzyme, preferably a deoxyribonuclease or ribonuclease enzyme

    摘要翻译： 用核酸酶，优选脱氧核糖核酸酶或核糖核酸酶的水溶液处理疏水改性纺织品的方法，漂洗和干燥纺织品。 使用整理步骤来改进用核酸酶酶，优选脱氧核糖核酸酶或核糖核酸酶的水溶液的清洗

    β-HEXOSAMINIDASE PROTEIN VARIANTS AND ASSOCIATED METHODS FOR TREATING GM2 GANGLIOSIDOSES
    7.
    发明申请
    β-HEXOSAMINIDASE PROTEIN VARIANTS AND ASSOCIATED METHODS FOR TREATING GM2 GANGLIOSIDOSES 审中-公开
    β-HEXOSAMINIDASE蛋白变体及相关方法治疗GM2 GANGLIOSIDOSES

    公开(公告)号：WO2015150922A2

    公开(公告)日：2015-10-08

    申请号：PCT/IB2015001208

    申请日：2015-03-17

    申请人： HOSPITAL FOR SICK CHILDREN ,  UNIV MANITOBA

    发明人： MAHURAN DON ,  MARK BRIAN

    IPC分类号： C12N15/56

    CPC分类号： C12N9/2402 ,  A61K38/00 ,  C12Y302/01052

    摘要： Embodiments herein include variants of β-hexosaminidase that are useful for hydrolyzing GM2 ganglioside, polynucleotides encoding the same, and related methods. In various embodiments, a variant β-hexosaminidase subunit is included wherein the variant β-hexosaminidase subunit forms a homodimer under physiological conditions and wherein the variant β- hexosaminidase subunit associates with GM2 activator protein to hydrolyze GM2 ganglioside. In some embodiments, an isolated or recombinant polynucleotide encoding such a variant β-hexosaminidase subunit is included. In some embodiments, a method of treating a subject exhibiting an abnormal cellular accumulation of GM2 ganglioside is included wherein the method includes administering a composition including a protein variant of β-hexosaminidase or a polynucleotide encoding the same. Other embodiments are included herein.

    摘要翻译： 本文的实施方案包括可用于水解GM2神经节苷脂的β-己糖胺酶的变体，及其编码的多核苷酸以及相关方法。 在各种实施方案中，包括变体β-己糖胺酶亚基，其中变体β-己糖胺酶亚基在生理条件下形成同二聚体，并且其中所述变体β-己糖氨酰胺酶亚基与GM2激活蛋白缔合以水解GM2神经节苷脂。 在一些实施方案中，包括编码这种变体β-己糖胺酶亚基的分离或重组多核苷酸。 在一些实施方案中，包括治疗表现出GM2神经节苷脂异常细胞积聚的受试者的方法，其中所述方法包括施用包含β-氨基己糖苷酶的蛋白质变体或其编码的多核苷酸的组合物。 其他实施例包括在本文中。

    GLYCOPROTEINS
    8.
    发明申请
    GLYCOPROTEINS 审中-公开
    糖蛋白

    公开(公告)号：WO2015080603A1

    公开(公告)日：2015-06-04

    申请号：PCT/NZ2014/050014

    申请日：2014-11-28

    申请人： FAIRBANKS, Antony John

    发明人： FAIRBANKS, Antony John

    IPC分类号： C07K1/107 ,  C07K1/08 ,  C07K1/36 ,  C12P21/04 ,  A61K38/51 ,  A61P43/00

    CPC分类号： C12Y302/01052 ,  A61K38/00 ,  C07K1/1077 ,  C12P21/005

    摘要： The present invention relates generally to phosphorylated glycoproteins and glycopeptides, methods of chemoenzymatic synthesis of phosphorylated glycoproteins or glycopeptides, compositions comprising such phosphorylated glycoproteins or glycopeptides, therap eutic methods utilizing such phosphorylated glycoproteins or glycopeptides, and to the use of such phosphorylated glycoproteins or glycopeptides in the manufacture of medicaments.

    摘要翻译： 本发明一般涉及磷酸化糖蛋白和糖肽，磷酸化糖蛋白或糖肽的化学酶合成方法，包含这种磷酸化糖蛋白或糖肽的组合物，利用这种磷酸化糖蛋白或糖肽的治疗方法，以及使用这种磷酸化糖蛋白或糖肽 制药。

    COMPOSITIONS FOR THE RESTORATION OF A FECAL MICROBIOTA AND METHODS FOR MAKING AND USING THEM
    9.
    发明申请
    COMPOSITIONS FOR THE RESTORATION OF A FECAL MICROBIOTA AND METHODS FOR MAKING AND USING THEM 审中-公开
    用于恢复FECAL MICROBIOTA的组合物及其制备和使用它们的方法

    公开(公告)号：WO2014078911A1

    公开(公告)日：2014-05-30

    申请号：PCT/AU2013/001362

    申请日：2013-11-26

    申请人： BORODY, Thomas Julius

    发明人： BORODY, Thomas Julius

    IPC分类号： A61K35/38 ,  A61P1/00 ,  C07K14/195

    CPC分类号： A61K35/38 ,  A61K9/19 ,  A61K9/2004 ,  A61K31/341 ,  A61K31/4164 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/606 ,  A61K31/635 ,  A61K31/655 ,  A61K31/706 ,  A61K35/74 ,  A61K35/741 ,  A61K35/742 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K35/76 ,  A61K36/28 ,  A61K36/31 ,  A61K36/48 ,  A61K36/8962 ,  A61K38/40 ,  A61K38/465 ,  A61K38/47 ,  A61K38/51 ,  A61K45/06 ,  A61K2300/00 ,  C12N1/20 ,  C12Y301/21001 ,  C12Y302/01 ,  C12Y302/01052 ,  Y02A50/473

    摘要： In alternative embodiments, the invention provides compositions and methods for treating various disorders and conditions in mammals, including chronic disorders in which there is a presence of an abnormal microbiota or an abnormal distribution of microflora in the gastrointestinal tract. In alternative embodiments, the invention provides liquid preparations or formulations derived from a human fecal material (e.g., a stool) processed, e.g., filtered and/or centrifuged, such that all bacteria, fungal spores and viruses are removed, but retaining the native biologically active molecules from the fecal material and bacteriophages. In alternative embodiments, the invention provides a "rough-", "incomplete-" or medium- filtered microbiota which still comprises native physiological components or nutritive agents for the bacteria, e.g., retains native biologically and nutritionally active components. In alternative embodiments, the invention provides a highly filtered or substantially purified microbiota in combination with, or having added back, a liquid preparation or formulation of the invention. In alternative embodiments, the invention provides compositions or formulations where the bacteria, or microbiota, component has been cultured, or cultured under anaerobic conditions, or harvested, stored and/or cultured under anaerobic conditions. In alternative embodiments, the invention provides various additives, compositions and donor restrictions for treating these disorders and conditions.

    摘要翻译： 在替代实施方案中，本发明提供用于治疗哺乳动物中各种病症和病症的组合物和方法，包括其中在胃肠道中存在异常微生物群或微生物群落的异常分布的慢性病症。 在替代实施方案中，本发明提供来自人类粪便物质（例如，粪便）的液体制剂或制剂，例如经过过滤和/或离心处理，使得除去所有细菌，真菌孢子和病毒，但保留天然生物学 来自粪便物质和噬菌体的活性分子。 在替代实施方案中，本发明提供了一种“粗”，“不完全”或中等过滤的微生物群，其还包含细菌的天然生理成分或营养剂，例如保留天然生物和营养活性成分。 在替代实施方案中，本发明提供与本发明的液体制剂或制剂组合或加入的高度过滤或基本上纯化的微生物群。 在替代实施方案中，本发明提供其中细菌或微生物组分已经在厌氧条件下培养或培养，或在厌氧条件下收获，储存和/或培养的组合物或制剂。 在替代实施方案中，本发明提供用于治疗这些疾病和病症的各种添加剂，组合物和供体限制。