公开(公告)号：WO2004106487A2

公开(公告)日：2004-12-09

申请号：PCT/NZ2004/000116

申请日：2004-06-03

Applicant: AGRESEARCH LIMITED ,  TAPPER, Brian, Anthony ,  COOPER, Bruce, Matheson ,  EASTON, Herrick, Sydney ,  FLETCHER, Lester, Ronald ,  HUME, David, Edward ,  LANE, Geoffrey, Alexander ,  LATCH, Garrick, Cecil, Morland ,  PENNELL, Christopher, Gerald, Lee ,  POPAY, Alison, Jean ,  CHRISTENSEN, Michael, John

Inventor： TAPPER, Brian, Anthony ,  COOPER, Bruce, Matheson ,  EASTON, Herrick, Sydney ,  FLETCHER, Lester, Ronald ,  HUME, David, Edward ,  LANE, Geoffrey, Alexander ,  LATCH, Garrick, Cecil, Morland ,  PENNELL, Christopher, Gerald, Lee ,  POPAY, Alison, Jean ,  CHRISTENSEN, Michael, John

IPC: C12N

CPC classification number: A01H15/00 ,  A01N63/04 ,  C12P17/18 ,  C12R1/645 ,  Y10S435/911

Abstract: An endophyte or endophyte culture of N. Iolii species is described that, in combination with a host grass does not cause typical symptoms of ryegrass toxicosis in grazing animals and also contains levels of compounds from the class of janthitrems epoxides to individually or in combination protect the host grass from pests or abiotic stresses or both. Uses and methods are also described to produce and characterise the combination as well as alternative uses for compounds from the class of janthitrem epoxide compounds.

Abstract translation: 描述了N.Iolii物种的内生真菌或内生真菌培养物，其与宿主草组合不会在放牧动物中引起黑麦草中毒的典型症状，并且还含有来自类别的珠穆朗定子环氧化物的化合物水平以单独或组合保护 宿主草从害虫或非生物胁迫或两者。 还描述了用途和方法来产生和表征该组合以及来自类似于janthitrem环氧化合物的化合物的替代用途。

公开(公告)号：WO0154510A9

公开(公告)日：2002-10-17

申请号：PCT/US0102715

申请日：2001-01-26

Applicant: OMEGATECH INC ,  REUCKER CRAIG M ,  DIMASI DON ,  HANSEN JON M ,  MIRRASOUL PETER J ,  BAILEY RICHARD B ,  WEEDER GEORGE T III ,  KANEKO TATSUO ,  BARCLAY WILLIAM R

Inventor： REUCKER CRAIG M ,  DIMASI DON ,  HANSEN JON M ,  MIRRASOUL PETER J ,  BAILEY RICHARD B ,  WEEDER GEORGE T III ,  KANEKO TATSUO ,  BARCLAY WILLIAM R

IPC: C12N15/09 ,  A23B7/10 ,  A23D9/00 ,  A23L1/03 ,  C12N1/00 ,  C12N1/12 ,  C12N1/13 ,  C12P7/64 ,  C12R1/89

CPC classification number: A23K50/80 ,  A23D9/00 ,  A23K20/158 ,  A23L29/065 ,  A23V2002/00 ,  C11B1/10 ,  C12N1/00 ,  C12N1/12 ,  C12P7/6409 ,  C12P7/6427 ,  C12P7/6472 ,  Y10S435/911

Abstract: The present invention provides a process for growing eukaryotic microorganisms, which are capable of producing lipids, in particular, lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.

Abstract translation: 本发明提供了一种生长真核微生物的方法，其能够产生脂质，特别是含有多烯脂肪酸的脂质。 本发明还提供了一种生产真核微生物脂质的方法。

公开(公告)号：WO00073511A1

公开(公告)日：2000-12-07

申请号：PCT/EP2000/004915

申请日：2000-05-25

IPC: G01N33/50 ,  A61K45/00 ,  A61P31/18 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/15 ,  G01N33/569 ,  A61K31/44 ,  A61K31/505 ,  G06F19/00

CPC classification number: C12Q1/703 ,  Y10S435/911 ,  Y10S435/912

Abstract: The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic characterization of a target population of HIV and the subsequent correlation of this information to phenotypic interpretation in order to correlate virus mutational profiles with drug resistance. The invention also relates to methods of utilizing the mutational profiles of the invention in databases, drug development, i.e. , drug design, and drug modification, therapy and treatment design, clinical management and diagnostic analysis.

Abstract translation: 本发明提供与HIV药物的表型抗性相关的HIV-1逆转录酶和/或蛋白酶基因的新突变，突变组合或突变分布。 更具体地，本发明涉及HIV的目标群体的基因型表征的使用以及该信息随后与表型解释的相关性，以将病毒突变特征与耐药性相关联。 本发明还涉及在数据库，药物开发，即药物设计，药物修饰，治疗和治疗设计，临床管理和诊断分析中利用本发明的突变特征的方法。

公开(公告)号：WO00069561A1

公开(公告)日：2000-11-23

申请号：PCT/US2000/013220

申请日：2000-05-12

IPC: B01L7/00 ,  B01L7/02 ,  C12M1/02 ,  F28D15/00 ,  B01L3/00 ,  C12M1/34 ,  C12M1/36 ,  F28F7/00 ,  F28F27/02 ,  F28D13/06

CPC classification number: B01L7/5255 ,  B01L7/02 ,  B01L7/52 ,  B01L2300/12 ,  B01L2300/185 ,  F28D15/00 ,  Y10S435/911 ,  Y10S435/912

Abstract: An apparatus (figure 8) for temperature control of biological/chemical samples employing liquid metal (83) is described. A gallium-indium alloy may be used to provide excellent temperature control. Methods of using liquid metal to provide temperature control for biological/chemical samples are also described. A preferred use for the described liquid metal-heating apparatus is to provide precise temperature control for polymerase chain reaction (PCR).

Abstract translation: 描述了使用液态金属（83）的生物/化学样品的温度控制的装置（图8）。 可以使用镓铟合金来提供优异的温度控制。 还描述了使用液态金属为生物/化学样品提供温度控制的方法。 所述液体金属加热装置的优选用途是为聚合酶链反应（PCR）提供精确的温度控制。

公开(公告)号：WO99067272A1

公开(公告)日：1999-12-29

申请号：PCT/JP1999/003191

申请日：1999-06-16

IPC: C12N1/20 ,  A61K31/704 ,  A61P31/04 ,  C07J63/00 ,  C07J71/00 ,  C12P19/60 ,  C07J3/00 ,  A61K31/575 ,  C12R1/645

CPC classification number: C12R1/645 ,  C07J63/008 ,  C12P19/60 ,  Y10S435/911

Abstract: The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided are a pharmaceutical composition comprising the compound and pharmaceutically acceptable carrier, a use of the WF002 as a medicament and use of the compound for manufacture of the medicament for treatment of infectious disease.

Abstract translation: 本发明提供了具有抗病原微生物的抗微生物活性的新的式（I）生物活性化合物及其生产方法。 还提供了包含该化合物和药学上可接受的载体的药物组合物，该WF002作为药物的用途以及该化合物用于制备用于治疗感染性疾病的药物的用途。

公开(公告)号：WO99057302A1

公开(公告)日：1999-11-11

申请号：PCT/JP1999/002171

申请日：1999-04-23

IPC: A23J3/34 ,  A23L27/50 ,  C12P1/02 ,  C12P21/00 ,  C12P21/06

CPC classification number: C12P21/00 ,  A23J3/346 ,  A23L27/50 ,  C12P1/02 ,  C12R1/69 ,  Y10S435/911 ,  Y10S435/913 ,  Y10S435/918

Abstract: A process for obtaining a protein hydrolyzate by enzymatically hydrolyzing a vegetable protein material containing saccharides by using a mold culture in a liquid reaction system, which comprises mixing the vegetable protein material with the mold culture, effecting the reaction first under aeration and agitation within a temperature range of from 15 to 39 DEG C, then ceasing the aeration and completing the reaction within a temperature range of from 40 to 60 DEG C. By using this method, enzymatic hydrolyzates of vegetable protein materials can be prevented from browning.

Abstract translation: 一种通过在液体反应体系中使用霉菌培养来酶解水解包含糖类的植物蛋白质材料来获得蛋白质水解产物的方法，该方法包括将植物蛋白材料与模具培养物混合，首先在通风和搅拌下在温度下进行反应 范围为15〜39℃，然后在40〜60℃的温度范围内停止通气并完成反应。通过使用该方法，可以防止植物蛋白物质的酶水解产物变褐。

公开(公告)号：WO99025876A1

公开(公告)日：1999-05-27

申请号：PCT/US1998/024520

申请日：1998-11-17

IPC: C12N15/10 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12N15/63 ,  C12N15/70 ,  C12P19/34 ,  C12Q1/70 ,  G01N33/53

CPC classification number: C12N15/1086 ,  C12Q1/6897 ,  Y10S435/911 ,  Y10S435/912

Abstract: The present invention is directed to a method for detection, characterization and isolation of nucleic acids encoding proteins of a desired property, such as a particular cellular localization. The invention further provides for rapid expression of such proteins or glycoproteins in mammalian cells and for facilitated purification of the novel secreted proteins or glycoproteins. Further, the invention provides for radioactive labelling of the novel proteins or glycoproteins, for rapid identification of sites of binding including animals and for rapid production of infective viral vectors for use in gene transfer.

Abstract translation: 本发明涉及用于检测，表征和分离编码具有所需性质（例如特定细胞定位）的蛋白质的核酸的方法。 本发明进一步提供了这些蛋白质或糖蛋白在哺乳动物细胞中的快速表达，并促进新分泌的蛋白质或糖蛋白的纯化。 此外，本发明提供新型蛋白质或糖蛋白的放射性标记，用于快速鉴定包括动物在内的结合位点，并快速产生用于基因转移的感染性病毒载体。

公开(公告)号：WO99006584A1

公开(公告)日：1999-02-11

申请号：PCT/US1998/015670

申请日：1998-07-28

IPC: C12N9/24 ,  C12P7/06 ,  C12P7/10 ,  C12P19/14 ,  C12P7/08 ,  C12N1/16 ,  C12N9/26 ,  C12P19/02

CPC classification number: C12Y302/01055 ,  C12N9/2402 ,  C12P7/06 ,  C12P7/10 ,  C12P19/14 ,  Y02E50/16 ,  Y02E50/17 ,  Y10S435/911

Abstract: A new alpha -L-arabinofuranosidase enzym which is highly thermostable, and is effective for the hydrolysis of arabinofuranosyl residues from L-arabinose containing polysaccharides and hemicelluloses is disclosed. The enzyme is produced by color variant A. pullulans strain NRRL Y-21792. This alpha -L-arabinofuranosidase may be used in conjunction with xylanolytic enzymes for the treatment of hemicellulosic materials to produce fermentable sugars, particularly xylose and L-arabinose.

Abstract translation: 公开了一种高度热稳定的新的α-L-阿拉伯呋喃糖苷酶酶，并且对于从含有L-阿拉伯糖的多糖和半纤维素中水解阿拉伯呋喃糖残基是有效的。 该酶由颜色变种A.支链淀粉菌株NRRL Y-21792产生。 该α-L-阿拉伯呋喃糖苷酶可以与木聚糖分解酶结合使用，用于处理半纤维素材料以产生可发酵糖，特别是木糖和L-阿拉伯糖。

公开(公告)号：WO99002662A1

公开(公告)日：1999-01-21

申请号：PCT/CA1998/000668

申请日：1998-07-10

IPC: C12N9/24 ,  C12N9/42 ,  C12N1/14 ,  C12N15/01

CPC classification number: C12Y302/01039 ,  C12N9/244 ,  C12R1/645 ,  C12Y302/01004 ,  C12Y302/01006 ,  C12Y302/01058 ,  C12Y302/01073 ,  Y10S435/911

Abstract: Strains of the aerobic mycoparasitic fungus Coniothyrium minitans having high levels of beta -glucanase activity have been obtained. Preferred strains have been deposited at the American Type Culture Collection under accession numbers 74415, 74416, 74417, 74418, 74419, 74435 and 74436. Methods for mutagenizing C. minitans 74415 and obtaining strains having beta -glucanase activity are provided.

Abstract translation: 已经获得了具有高水平的β-葡聚糖酶活性的需氧真菌寄生真菌菌丝体的菌株。 优选的菌株已经以保藏号74415,74416,74417,74418,74419,74435和74436保藏在美国典型培养物保藏中心。提供了诱变小分支杆菌74415并获得具有β-葡聚糖酶活性的菌株的方法。