公开(公告)号：WO2007109201A2

公开(公告)日：2007-09-27

申请号：PCT/US2007006747

申请日：2007-03-16

Applicant: RENOVIS INC ,  KELLY MICHAEL G ,  KINCAID JOHN ,  FANG YUNFENG ,  CAO YEYU ,  KAUB CARL ,  GOWLUGARI SUMITHRA ,  WANG ZHAN

Inventor： KELLY MICHAEL G ,  KINCAID JOHN ,  FANG YUNFENG ,  CAO YEYU ,  KAUB CARL ,  GOWLUGARI SUMITHRA ,  WANG ZHAN

IPC: A61K31/4704 ,  C07D217/22

CPC classification number: C07D401/06 ,  C07D217/24

Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract translation: 公开了双环杂芳基化合物，其具有由以下表示的式：化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物的多种病症，包括作为非限制性实例， 疼痛，炎症，创伤性损伤等。

公开(公告)号：WO2007109192A2

公开(公告)日：2007-09-27

申请号：PCT/US2007/006735

申请日：2007-03-16

Applicant: RENOVIS, INC. ,  KELLY, Michael, G. ,  KINCAID, John ,  FANG, Yunfeng ,  CAO, Yeyu ,  KAUB, Carl ,  GOWLUGARI, Sumithra ,  WANG, Zhan

Inventor： KELLY, Michael, G. ,  KINCAID, John ,  FANG, Yunfeng ,  CAO, Yeyu ,  KAUB, Carl ,  GOWLUGARI, Sumithra ,  WANG, Zhan

IPC: A61K31/4704 ,  C07D217/22

CPC classification number: C07D217/24 ,  C07D401/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following formula (I): the compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract translation: 公开了具有由下式（I）表示的式的双杂芳基化合物：该化合物可以制备成药物组合物，并可用于预防和治疗包括人在内的哺乳动物中的多种病症， 例如疼痛，炎症，创伤性损伤等。

公开(公告)号：WO2005079270A3

公开(公告)日：2005-09-01

申请号：PCT/US2005/004236

申请日：2005-02-11

Applicant: RENOVIS, INC. ,  KELLY, Michael, G. ,  JANAGANI, Satyanarayana ,  KINCAID, John

Inventor： KELLY, Michael, G. ,  JANAGANI, Satyanarayana ,  KINCAID, John

IPC: C07C261/00 ,  A61K31/15

Abstract: The present invention provides aryl nitrones, compositions comprising the same and methods of their use for the treatment or prevention of oxidative, ischemic, ischemia/reperfusion-related and chemokine mediated conditions.

公开(公告)号：WO2005032493A8

公开(公告)日：2005-06-30

申请号：PCT/US2004033403

申请日：2004-10-07

Applicant: RENOVIS INC ,  KELLY MICHAEL G ,  JANAGANI SATYANARAYANA ,  WU GUOXIAN ,  KINCAID JOHN

Inventor： KELLY MICHAEL G ,  JANAGANI SATYANARAYANA ,  WU GUOXIAN ,  KINCAID JOHN

IPC: A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/75 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  A61K

CPC classification number: C07D405/12 ,  C04B35/632 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/75 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

公开(公告)号：WO2005046683A1

公开(公告)日：2005-05-26

申请号：PCT/US2004/033163

申请日：2004-10-07

Applicant: RENOVIS, INC. ,  UPASANI, Ravindra, B. ,  KELLY, Michael, G. ,  JANAGANI, Satyanarayana

Inventor： UPASANI, Ravindra, B. ,  KELLY, Michael, G. ,  JANAGANI, Satyanarayana

IPC: A61K31/44

CPC classification number: C07D319/18 ,  C04B35/632 ,  C07C233/65 ,  C07C233/66 ,  C07C233/69 ,  C07C233/73 ,  C07C233/75 ,  C07C255/60 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D207/337 ,  C07D209/08 ,  C07D209/14 ,  C07D209/16 ,  C07D209/18 ,  C07D209/88 ,  C07D211/34 ,  C07D211/58 ,  C07D213/40 ,  C07D213/53 ,  C07D213/56 ,  C07D213/70 ,  C07D213/75 ,  C07D213/82 ,  C07D215/12 ,  C07D215/38 ,  C07D217/02 ,  C07D221/10 ,  C07D221/12 ,  C07D221/14 ,  C07D231/40 ,  C07D233/54 ,  C07D233/61 ,  C07D233/64 ,  C07D239/42 ,  C07D277/46 ,  C07D295/13 ,  C07D295/135 ,  C07D307/14 ,  C07D307/52 ,  C07D307/54 ,  C07D317/50 ,  C07D317/58 ,  C07D319/12 ,  C07D333/20 ,  C07D333/24 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06

Abstract: Compounds are disclosed that have a formula represented by the following: Formula (I) The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract translation: 公开了具有由下式表示的式的化合物：式（I）化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症， 疼痛，炎症，创伤性损伤等。

公开(公告)号：WO2007109172A3

公开(公告)日：2009-04-30

申请号：PCT/US2007006700

申请日：2007-03-16

Applicant: RENOVIS INC ,  KELLY MICHAEL G ,  KINCAID JOHN ,  FANG YUNFENG ,  CAO YEYU ,  KAUB CARL ,  GOWLUGARI SUMITHRA ,  WANG ZHAN

Inventor： KELLY MICHAEL G ,  KINCAID JOHN ,  FANG YUNFENG ,  CAO YEYU ,  KAUB CARL ,  GOWLUGARI SUMITHRA ,  WANG ZHAN

IPC: C07D217/22 ,  A61K31/4704

CPC classification number: C07D217/22 ,  C07D217/24 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12

Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract translation: 公开了具有由下式表示的式的式（I）的双杂环芳基化合物。 化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

公开(公告)号：WO2007109192A3

公开(公告)日：2007-11-22

申请号：PCT/US2007006735

申请日：2007-03-16

Applicant: RENOVIS INC ,  KELLY MICHAEL G ,  KINCAID JOHN ,  FANG YUNFENG ,  CAO YEYU ,  KAUB CARL ,  GOWLUGARI SUMITHRA ,  WANG ZHAN

Inventor： KELLY MICHAEL G ,  KINCAID JOHN ,  FANG YUNFENG ,  CAO YEYU ,  KAUB CARL ,  GOWLUGARI SUMITHRA ,  WANG ZHAN

IPC: A01N43/40

CPC classification number: C07D217/24 ,  C07D401/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following formula (I): the compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract translation: 公开了具有由下式（I）表示的式的双环杂芳基化合物：所述化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括通过非 - 限制性例子，疼痛，炎症，创伤性损伤等。

公开(公告)号：WO2007109160A9

公开(公告)日：2007-11-15

申请号：PCT/US2007006685

申请日：2007-03-16

Applicant: RENOVIS INC ,  KELLY MICHAEL G ,  KINCAID JOHN ,  FANG YUNFENG ,  CAO YEYU ,  KAUB CARL ,  GOWLUGARI SUMITHRA

Inventor： KELLY MICHAEL G ,  KINCAID JOHN ,  FANG YUNFENG ,  CAO YEYU ,  KAUB CARL ,  GOWLUGARI SUMITHRA

IPC: A61K31/4704 ,  A61K31/4745 ,  C07D217/22

CPC classification number: C07D217/24 ,  C07D401/06 ,  C07D405/06 ,  C07D405/10 ,  C07D471/04

Abstract: Bicycloheteroaryl compounds are disclosed that have formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract translation: 公开了具有式（I）的双杂杂芳基化合物。 化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

公开(公告)号：WO2007109160A2

公开(公告)日：2007-09-27

申请号：PCT/US2007/006685

申请日：2007-03-16

Applicant: RENOVIS, INC. ,  KELLY, Michael, G. ,  KINCAID, John ,  FANG, Yunfeng ,  CAO, Yeyu ,  KAUB, Carl ,  GOWLUGARI, Sumithra

Inventor： KELLY, Michael, G. ,  KINCAID, John ,  FANG, Yunfeng ,  CAO, Yeyu ,  KAUB, Carl ,  GOWLUGARI, Sumithra

IPC: A61K31/4704 ,  C07D217/22 ,  A61K31/4745

CPC classification number: C07D217/24 ,  C07D401/06 ,  C07D405/06 ,  C07D405/10 ,  C07D471/04

Abstract: Bicycloheteroaryl compounds are disclosed that have formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract translation: 公开了具有式（I）的双环杂芳基化合物。 所述化合物可制备成药物组合物，并且可用于预防和治疗包括人在内的哺乳动物的各种病症，包括非限制性实例，疼痛，炎症，创伤性损伤等。

公开(公告)号：WO2007028022A2

公开(公告)日：2007-03-08

申请号：PCT/US2006034236

申请日：2006-09-01

Applicant: RENOVIS INC ,  KINCAID JOHN ,  CAO YEYU ,  KAUB CARL ,  LONERGAN DAVID ,  KELLY MICHAEL G

Inventor： KINCAID JOHN ,  CAO YEYU ,  KAUB CARL ,  LONERGAN DAVID ,  KELLY MICHAEL G

IPC: A61K31/655

CPC classification number: C07D471/04

Abstract: Compounds are disclosed that have a formula represented by the following (I), the compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract translation: 公开了具有由以下（I）表示的式的化合物，该化合物可以制备为药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括通过非限制性的方式 例如疼痛，炎症，创伤性损伤等。