公开(公告)号：WO2021148787A1

公开(公告)日：2021-07-29

申请号：PCT/GB2021/050123

申请日：2021-01-20

Applicant: OXFORD UNIVERSITY INNOVATION LIMITED

Inventor： COHEN KADOSH, Roi ,  REED, Thomas ,  NGUYEN, Vu ,  VAN BUEREN, Nienke

IPC: A61N1/36 ,  A61N1/04 ,  A61N1/0456 ,  A61N1/36025 ,  A61N1/3603

Abstract: This disclosure relates to transcranial stimulation. In one arrangement, a method for obtaining personalized parameters for transcranial stimulation is provided. Baseline data about a test subject are received, the baseline data comprising information about the test subject acquired prior to transcranial stimulation applied to the test subject. A Gaussian process model of performance of one or more training subjects is used to obtain personalized parameters for transcranial stimulation for the test subject based on the received baseline data. The Gaussian process jointly models subject performance during and/or after transcranial stimulation as a function of both i) parameters defining the transcranial stimulation; and ii) baseline data for the one or more training subjects.

公开(公告)号：WO2021126097A1

公开(公告)日：2021-06-24

申请号：PCT/TR2019/051093

申请日：2019-12-17

Applicant: CAKMAK, Yusuf Ozgur

Inventor： CAKMAK, Yusuf Ozgur

IPC: A61N1/04 ,  A61N1/36 ,  A61N5/06 ,  A61N1/372 ,  A61B5/01 ,  A61B5/024 ,  A61B5/04 ,  A61B5/00 ,  A61B2562/0204 ,  A61B2562/0219 ,  A61B2562/0233 ,  A61B2562/0271 ,  A61B5/0077 ,  A61B5/02405 ,  A61B5/02416 ,  A61B5/02438 ,  A61B5/0531 ,  A61B5/1103 ,  A61B5/1118 ,  A61B5/30 ,  A61B5/369 ,  A61B5/389 ,  A61B5/4803 ,  A61B5/4848 ,  A61B5/6822 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36031 ,  A61N1/37217 ,  A61N2/002 ,  A61N2/006 ,  A61N2005/0626 ,  A61N2005/0645 ,  A61N2005/0659 ,  A61N2007/0026 ,  A61N5/0622

Abstract: The present invention relates to a stimulation device comprising a body containing at least one stimulation means and adapted to be transcutaneously attached to the neck of a subject where said stimulation means is adapted to generate a stimulating signal during a stimulating state. Said stimulation means is positioned to be in stimulating contact with the sternocleidomastoid muscle and the trunks of the lesser occipital nerve, greater auricular nerve, transverse cervical nerve or supraclavicular nerve with their autonomic fibers synchronously. The stimulation can be provided in the form an electrical, optical, vibrational, thermal, mechanical and/or magnetic stimulation. The stimulation device can be used bilaterally on the right and left sides of the subject's neck, working as a unit in a synchronous or alternating manner.

公开(公告)号：WO2022130183A2

公开(公告)日：2022-06-23

申请号：PCT/IB2021/061665

申请日：2021-12-13

Applicant: NOVOCURE GMBH

Inventor： WASSERMAN, Yoram ,  OBUCHOVSKY, Stas ,  KUPLENNIK, Nataliya

IPC: A61N1/04 ,  A61N1/05 ,  A61N1/36 ,  A61N1/40 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0529 ,  A61N1/36002 ,  A61N1/36025 ,  A61N1/3603 ,  H01L37/02

Abstract: TTFields are applied using transducer arrays made from a plurality of individual electrode elements. The temperatures of those electrode elements can be normalized by positioning respective regions of pyroelectric material in thermal contact with the electrode elements, and subsequently applying an AC signal to each of the electrode elements at respective duty cycles so that an alternating electric field is induced within the subject. For each of the regions of the pyroelectric material, an electrical characteristic that is related to temperature is measured after the AC signal turns off. The duty cycles of the AC signals that are applied to the electrode elements is adjusted until the measured electrical characteristics indicate that the temperatures of all the regions of the pyroelectric material have equalized to within 1° C.

公开(公告)号：WO2021175898A1

公开(公告)日：2021-09-10

申请号：PCT/EP2021/055278

申请日：2021-03-03

Applicant: GRETAP AG

Inventor： TASS, Peter Alexander

IPC: A61N1/36 ,  A61H23/00 ,  A61M21/00 ,  A61H2201/0157 ,  A61H2201/1207 ,  A61H2201/1607 ,  A61H2205/02 ,  A61H23/008 ,  A61H23/0245 ,  A61M2021/0022 ,  A61M2021/0027 ,  A61M2021/0044 ,  A61M2021/0066 ,  A61M2021/0072 ,  A61M2209/088 ,  A61N1/36025

Abstract: The present invention pertains to a medical treatment device (10) for stimulating neurons of a patient to suppress a pathologically synchronous activity of the neurons. The device (10) comprises a non-invasive stimulation unit (12) configured for simultaneously administering at least one acoustic stimulus and at least one non-acoustic stimulus to a patient's body, each of which is configured to suppress the pathologically synchronous activity when being administered to the patient's body.

公开(公告)号：WO2021148715A1

公开(公告)日：2021-07-29

申请号：PCT/FI2021/050028

申请日：2021-01-20

Applicant: SALUSTIM GROUP OY

Inventor： NISKANEN, Tero ,  NISSILÄ, Seppo

IPC: A61N1/04 ,  A61N1/36 ,  A61H39/002 ,  A61N1/0456 ,  A61N1/0472 ,  A61N1/0484 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36036 ,  H01M4/02

Abstract: The invention relates to nerve stimulation electrode structure for external ear, said electrode structure comprising a first electrode (111), a second electrode (112), a base (B) for supporting the electrodes, said electrode structure further comprising connecting points (113, 114) for the electrodes for creating connection to a stimulation device (106). At least in the area between the electrodes the base (B), said base being planar, comprises a flexible bending area (130) for enabling the electrode structure to be bent to an inclined position forming a first wing (W1) for the first electrode and a second wing (W2) for the second electrode for enabling electrode contact to the ear on both outer sides of the bended electrode structure.

公开(公告)号：WO2023275718A1

公开(公告)日：2023-01-05

申请号：PCT/IB2022/055955

申请日：2022-06-27

Applicant: NOVOCURE GMBH

Inventor： WASSERMAN, Yoram ,  WEINBERG, Uri ,  OBUCHOVSKY, Stas ,  KUPLENNIK, Nataliya ,  SHAPIRO, David ,  SHTOTLAND, Michael ,  KIRILLOV, Sergei

IPC: A61N1/04 ,  A61N1/36 ,  A61N1/40 ,  A61B5/0537 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/36002 ,  A61N1/36025 ,  A61N1/3603

Abstract: Tumor treating fields (TTFields) can be delivered to a subject's body with improved safety and efficacy by determining the condition of participating electrode elements and/or the subject's skin condition under positioned electrode elements. This may be accomplished by applying an AC signal to pairs or groups of electrode elements and taking corresponding impedance measurements. In some embodiments, the impedance measurements are indicative of electrode element condition and/or skin condition. These determined conditions can be used to adjust or pause TTFields treatment, for example to permit skin recovery or to ensure that participating electrode elements will properly function.

公开(公告)号：WO2022170443A1

公开(公告)日：2022-08-18

申请号：PCT/CA2022/050214

申请日：2022-02-14

Applicant: RALSTON, John D.

Inventor： PETERS, Ryan Michael ,  BANMAN, Christopher J.

IPC: A61B5/11 ,  A61B5/00 ,  G16H50/50 ,  A61B2562/0219 ,  A61B5/1116 ,  A61B5/1126 ,  A61B5/4023 ,  A61B5/4842 ,  A61B5/4848 ,  A61B5/6814 ,  A61B5/7264 ,  A61B5/7275 ,  A61N1/36025 ,  A61N1/36031 ,  A61N1/36046 ,  G16H20/30 ,  G16H40/63 ,  G16H50/20 ,  G16H50/70

Abstract: A system includes a sensing assembly configured to be disposed on a mastoid of a user. The sensing assembly includes a housing, a first sensor disposed in the housing and configured to measure a first phybrata signal from the user, and a second sensor disposed in the housing and configured to measure a second phybrata signal from the user, the second phybrata signal different from the first phybrata signal. A controller is in communication with the sensing assembly. The controller is configured to: receive a first phybrata data from the sensing assembly, the first phybrata data including information obtained from the first phybrata signal and the second phybrata signal. The controller is configured to determine a phybrata parameter associated with the user based on the first phybrata data, and determine a phybrata signature associated with the user based on the phybrata parameter.

公开(公告)号：WO2022020045A1

公开(公告)日：2022-01-27

申请号：PCT/US2021/038084

申请日：2021-06-18

Applicant: NEXALIN TECHNOLOGY, INC.

Inventor： CLAUDE, John Patrick

IPC: A61N1/00 ,  A61N1/04 ,  A61N1/36 ,  A61N1/36025 ,  A61N1/36034

Abstract: Transcranial electrostimulation systems and methods are contemplated in which a high current level, charge balanced alternating current electrical signal is generated for delivery to the occipital region of a patient's brain. By stimulating the brain with a charged balanced stimulation current with a stimulation current envelope defining one or more series of pulses at particular frequencies and durations designed to evoke metabolic response in the neurons, significant improvements in efficacy and reductions in patient discomfort may be achieved relative to earlier methods of transcranial electrical stimulation, especially those in which result in a resultant rectified direct current component being administered to the patient. Further advantages, especially in promoting neural entrainment, may be realized as well via utilizing multiple series of pulses at different frequencies, and via the dynamic adjustment of the stimulation waveform via incorporation of feedback signals in order to maintain charge balance in real-time.

公开(公告)号：WO2021245129A1

公开(公告)日：2021-12-09

申请号：PCT/EP2021/064780

申请日：2021-06-02

Applicant: NEUROCARE GROUP AG

Inventor： BERKES, Sebastian ,  STEIN, Patrick ,  SCHELLHORN, Klaus

IPC: A61B5/00 ,  A61N1/372 ,  A61N2/00 ,  A61B5/374 ,  A61B5/0004 ,  A61B5/0006 ,  A61N1/025 ,  A61N1/36025 ,  A61N2/006

Abstract: Die Erfindung betrifft ein System zur körperzustandsabhängigen Stimulation mittels Funktionsmodulen, z.B. einem Aktionsmodul (2, Modul D/A) zur Stimulation von Gewebe und einem Erfassungsmodul (3, Modul A/D) zur Ableitung Messung) von Biodaten oder Biosignalen, dadurch gekennzeichnet, dass die Kommunikation zwischen beiden Modulen über eine Kommunikationsverbindung (5) erfolgt, die harte oder zumindest feste Echtzeitanforderungen erfüllt. Bevorzugt umfasst die Kommunikationsverbindung (5) einen echtzeitfähigen Bus, an den die beiden Module angeschlossen sind, vor allem einen EtherCAT-Bus.

公开(公告)号：WO2021190762A1

公开(公告)日：2021-09-30

申请号：PCT/EP2020/058725

申请日：2020-03-27

Applicant: FONDATION ASILE DES AVEUGLES ,  DROPSLAB TECHNOLOGIES GMBH

Inventor： IONTA, Silvio ,  MINOUFEKR, Meysam ,  OSIMO, Sofia

IPC: G06F3/01 ,  A61N1/36 ,  A61B5/11 ,  A61B2505/09 ,  A61B3/113 ,  A61B5/1104 ,  A61B5/1122 ,  A61B5/1124 ,  A61B5/163 ,  A61B5/4836 ,  A61B5/6803 ,  A61B5/6897 ,  A61B5/745 ,  A61N1/20 ,  A61N1/36025 ,  G06F3/011 ,  G06F3/017

Abstract: A virtual reality (VR) system is used to render a 3D VR game scene comprising at least one VR object stimulus on a VR head mounted display screen. During a first training session, the VR system measures commands from the user dominant hand with a VR handle, and the time series of respectively the user head and the user hand positions and/or orientations vectors, as well as the time series of the user gaze direction vectors relative to the user head position and orientation origin in the 3D virtual environment. A HD-tDCS neurostimulation is applied to the user in a time range between one hour before and one hour after the first session. The VR system compares the measured user motion time series data with a reference motion time series data to determine a user motion drift for the first session, possibly with a principal component analysis (PCA) or a functional principal component analysis (FPCA) to extract and compare the principal components of the user motion time series of positions and/or orientations. If the user motion drift exceeds a threshold, the VR system adapts the rendering of at least one property of the VR object stimulus and/or the HT-tDCS neurostimulation in a next session.