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公开(公告)号：WO2020223538A8
公开(公告)日：2020-11-05
申请号：PCT/US2020/030819
申请日：2020-04-30
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , SHI, Lei , MURAUSKI, Kathleen, J. , XU, Xiangdong , TONG, Yunsong , RANDOLPH, John, T. , DART, Michael, J. , BENELKEBIR, Hanae , EDESON, Steven , STARBUCK, Kathryn
IPC分类号： C07D311/74 , A61P25/00 , A61P35/00 , A61P37/00 , C07C1/00 , C07D213/53 , C07D265/36 , C07D271/10 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D413/04 , C07D413/12 , C07D417/12 , A61K31/165 , A61K31/353 , A61K31/397 , A61K31/4025 , A61K31/403 , A61K31/4155 , A61K31/422 , A61K31/4245 , A61K31/437 , A61K31/4433 , A61K45/06 , A61P25/28 , C07C235/22 , C07C235/36 , C07C235/40 , C07C2601/04 , C07C2602/38 , C07C2602/44 , C07D311/22 , C07D311/24 , C07D471/04 , C07D471/08 , C07D493/08
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：WO2020077217A1
公开(公告)日：2020-04-16
申请号：PCT/US2019/055850
申请日：2019-10-11
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , DART, Michael, J. , FROST, Jennifer, M. , TONG, Yunsong , XU, Xiangdong , SHI, Lei , MURAUSKI, Kathleen , PLIUSHCHEV, Marina , BROWN, Brian, S. , VOIGHT, Eric , RANDOLPH, John, T.
IPC分类号： C07C235/36 , C07C271/34 , C07C303/34 , C07D221/00 , C07F9/09
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：WO2019090090A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058974
申请日：2018-11-02
发明人： MARTIN, Kathleen Ann , SIDRAUSKI, Carmela , FROST, Jennifer M. , TONG, Yunsong , XU, Xiangdong , SHI, Lei , XIONG, Zhaoming
IPC分类号： C07D487/10 , C07D205/04 , C07D207/08 , C07D209/44 , C07D211/18 , A61K31/397 , A61P35/00
CPC分类号： C07D487/10 , C07D205/04 , C07D207/08 , C07D209/44 , C07D211/18
摘要： Provided herein are compounds, compositions, and methods useful for the modulation of elF2B, for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：WO2019090085A8
公开(公告)日：2019-05-09
申请号：PCT/US2018/058969
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , FROST, Jennifer, M. , TONG, Yunsong , XU, Xiangdong , CHUNG, Seungwon , ZHANG, Qingwei, I. , SHI, Lei , MURAUSKI, Kathleen , DART, Michael, J. , RANDOLPH, John, T.
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , A61P19/00 , A61P25/00 , A61P3/00 , A61P21/00 , A61P29/00 , A61P35/00 , A61K31/16 , A61K31/165 , A61K31/538 , A61K31/352 , A61K31/36 , A61K31/498 , C07D311/66 , C07D319/20 , C07D405/12 , C07D413/06 , C07D265/36 , C07D493/04 , C07D207/22 , C07D209/42 , C07D307/84
摘要： Provided herein are compounds of formula (I), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions. (Formula I).
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公开(公告)号：WO2019090081A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058963
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , FROST, Jennifer, M. , TONG, Yunsong , XU, Xiangdong , SHI, Lei , CHUNG, Seungwon , XIONG, Zhaoming , MURAUSKI, Kathleen , ZHANG, Qingwei, I. , BROWN, Brian, S. , DART, Michael, J.
IPC分类号： C07D207/26 , C07D209/46 , C07D207/273 , C07D233/32 , C07D239/88 , C07D239/96 , C07D263/20 , C07D265/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D413/12 , A61P3/00 , A61P19/00
CPC分类号： C07D207/273 , A61P3/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P29/00 , A61P35/00 , C07D207/26 , C07D209/46 , C07D233/32 , C07D239/88 , C07D239/96 , C07D263/20 , C07D265/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D413/12
摘要： Provided herein are compounds of Formula (I) or Formula (II), compositions, and methods there of useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：WO2019090078A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058960
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , PLIUSHCHEV, Marina, A. , TONG, Yunsong , XU, Xiangdong , ZHANG, Qingwei, I. , SWEIS, Ramzi, Farah , DART, Michael, J.
IPC分类号： C07D233/64 , C07D249/08 , C07D271/06 , C07D271/10 , C07D401/12 , C07D413/12 , C07D471/04 , C07D491/04 , A61K31/4245 , A61K31/4355 , A61K31/437 , A61K31/4439 , A61P3/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D271/10 , A61P3/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P29/00 , A61P35/00 , C07D233/64 , C07D249/08 , C07D271/06 , C07D401/12 , C07D413/12 , C07D471/04 , C07D491/04
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：WO2019090074A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058955
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , PLIUSHCHEV, Marina, A. , FROST, Jennifer, M. , TONG, Yunsong , XU, Xiangdong , SHI, Lei , ZHANG, Qingwei, I. , XIONG, Zhaoming , SWEIS, Ramzi, Farah , DART, Michael, J. , MURAUSKI, Kathleen
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , C07D213/40 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/84 , C07D231/12 , C07D241/12 , C07D241/20 , C07D471/04 , C07D261/08 , C07D263/32 , C07D271/06
摘要： Provided herein are compounds of formula (I) and (II), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：WO2022094244A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/057300
申请日：2021-10-29
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , DART, Michael, J. , MURAUSKI, Kathleen, J. , RANDOLPH, John, T. , SHI, Lei , SMITH, Russell, C. , TONG, Yunsong , XU, Xiangdong , BENELKEBIR, Hanae , CHOHAN, Kamaldeep, K. , EDESON, Steven, J. , SCHWENK, Sebastian , STARBUCK, Kathryn, A.
IPC分类号： C07D231/12 , C07D231/18 , C07D231/20 , C07D231/56 , C07D311/24 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D471/04 , C07D213/64 , C07D249/04 , C07D401/04 , C07D401/06 , C07D403/04
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (I SR) and for treating related diseases, disorders, and conditions.
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公开(公告)号：WO2019090082A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058965
申请日：2018-11-02
发明人： MARTIN, Kathleen Ann , SIDRAUSKI, Carmela , FROST, Jennifer M. , TONG, Yunsong , XU, Xiangdong , XIONG, Zhaoming , DART, Michael J.
IPC分类号： C07D231/12 , C07D233/64 , C07D413/04 , C07D413/12 , C07D271/06 , A61K31/4245 , A61P35/00
CPC分类号： C07D271/10 , C07D207/33 , C07D231/12 , C07D233/64 , C07D271/06 , C07D413/04 , C07D413/12
摘要： Provided herein are compounds, compositions, and methods useful for the modulation of elF2B and the integrated stress response (ISR) signaling pathway and for treating related diseases, disorders and conditions.
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公开(公告)号：WO2019090076A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058957
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , FROST, Jennifer, M. , PLIUSHCHEV, Marina, A. , TONG, Yunsong , BLACK, Lawrence, A. , XU, Xiangdong , SHI, Lei , ZHANG, Qingwei, I. , CHUNG, Seungwon , SWEIS, Ramzi, Farah , DART, Michael, J. , RANDOLPH, John, T. , MURAUSKI, Kathleen
IPC分类号： C07D213/74 , C07C255/57 , C07D231/14 , C07D237/10 , C07D241/12 , C07D241/44 , C07D261/08 , C07C235/14 , C07D277/32 , C07D213/57 , C07D307/56 , C07D307/82 , C07D317/62 , C07D401/04 , C07D413/04 , C07D487/04 , C07D275/03 , C07D495/04 , C07D513/04 , C07D213/54 , A61P35/00 , A61K31/165
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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