- 专利标题： Humanized and affinity matured antibodies to FcRH5 and methods of use
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申请号： US16395009申请日： 2019-04-25
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公开(公告)号： US11192950B2公开(公告)日： 2021-12-07
- 发明人: Isidro Hotzel , Teemu T. Junttila , Ji Li , Justin Scheer , Danielle Dicara , Diego Ellerman , Christoph Spiess , Paul J. Carter
- 申请人： Genentech, Inc.
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Clark & Elbing LLP
- 代理商 Thomas J. Takara
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04 ; C12P21/06 ; C12P21/04 ; C12N5/00 ; C12N5/16 ; C12N1/20 ; C07K16/28 ; A61K47/68 ; A61K39/395 ; A61K45/06 ; C07K16/30 ; G01N33/574 ; C07K16/00 ; A61K39/00
摘要：
The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.