Invention Application
- Patent Title: Very large scale immobilized polymer synthesis
- Patent Title (中): 非常大规模的固定化聚合物合成
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Application No.: US11040520Application Date: 2005-01-21
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Publication No.: US20050214828A1Publication Date: 2005-09-29
- Inventor: Michael Pirrung , J. Read , Stephen Fodor , Lubert Stryer
- Applicant: Michael Pirrung , J. Read , Stephen Fodor , Lubert Stryer
- Applicant Address: US CA Santa Clara
- Assignee: Affymetrix, INC.
- Current Assignee: Affymetrix, INC.
- Current Assignee Address: US CA Santa Clara
- Main IPC: G01N33/48
- IPC: G01N33/48 ; B01J19/00 ; B01J19/08 ; B01L7/00 ; B05D3/00 ; C07B51/00 ; C07B61/00 ; C07C229/14 ; C07C229/16 ; C07C231/02 ; C07C237/22 ; C07D263/44 ; C07D317/62 ; C07H19/04 ; C07H19/10 ; C07H21/00 ; C07K1/04 ; C07K1/06 ; C07K7/06 ; C07K14/00 ; C07K16/00 ; C07K17/02 ; C07K17/06 ; C07K17/08 ; C07K17/14 ; C08F2/46 ; C12M1/34 ; C12Q1/68 ; C40B30/04 ; C40B40/06 ; C40B40/10 ; C40B60/14 ; G01N1/30 ; G01N15/14 ; G01N21/25 ; G01N21/64 ; G01N33/53 ; G01N33/533 ; G01N33/536 ; G01N33/541 ; G01N33/543 ; G01N33/566 ; G01N33/58 ; G01N37/00 ; G03F7/00 ; G03F7/26 ; G03F7/38 ; G11C13/02 ; H01L21/98
Abstract:
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
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