Approaches for partially reconfiguring a frame are disclosed. In one approach, a circuit arrangement includes programmable resources, frames of configuration memory cells, and partial configuration control memory cells. Each frame includes a plurality of subsets of configuration memory cells, and each subset configures one of the programmable resources. Each partial configuration control memory cell is coupled to a respective one of the subsets. Responsive to a first partial bitstream that includes a quantity of configuration data for all the subsets of configuration cells of a first frame of the plurality of frames, each subset of the configuration memory cells of the first frame is configurable or not configurable responsive to the state of the associated partial configuration control memory cell.