公开(公告)号：EP4436605A1

公开(公告)日：2024-10-02

申请号：EP22896787.3

申请日：2022-11-18

申请人： The Trustees of The University of Pennsylvania

发明人： LINGHAN, Mei ,  ZAPPALA, Fabiana ,  TSOURKAS, Andrew

IPC分类号： A61K39/44 ,  A61K38/16 ,  A61K47/64 ,  A61K47/65 ,  A61P35/00 ,  C07K14/31 ,  C07K14/315 ,  C07K16/18

CPC分类号： A61P35/00 ,  C07K14/31 ,  C07K14/315 ,  C07K16/2887 ,  C07K16/2809 ,  C07K16/468 ,  C07K16/00 ,  C07K2317/3120130101 ,  C07K16/2863 ,  C07K2317/62220130101 ,  C07K2317/7320130101 ,  C07K16/32 ,  C07K16/2803 ,  C07K2317/9220130101 ,  A61K47/65 ,  A61K38/00

公开(公告)号：EP4056588B1

公开(公告)日：2024-09-25

申请号：EP22162298.8

申请日：2016-04-08

IPC分类号： C07K14/725 ,  C07K16/28 ,  C12N5/0783 ,  A61K39/00

CPC分类号： C07K14/7051 ,  C07K2317/2420130101 ,  C07K2317/62220130101 ,  C07K2319/0020130101 ,  A61K2039/7020130101 ,  C07K16/2803 ,  C07K16/2866 ,  A61K45/06 ,  A61K38/00 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C12N5/0636 ,  A61K39/4636 ,  A61K39/464413 ,  A61K39/464419 ,  A61K2239/3820230501 ,  A61K39/4611 ,  A61K39/464424 ,  C12N5/0646 ,  A61K39/464412 ,  A61K2239/4820230501 ,  A61K39/4631

公开(公告)号：EP4429766A1

公开(公告)日：2024-09-18

申请号：EP22817646.7

申请日：2022-11-11

申请人： Université de Genève ,  Les Hôpitaux Universitaires de Genève ,  The Trustees of The University of Pennsylvania

发明人： MIGLIORINI, Denis ,  DE SOSTOA, Jana ,  DUTOIT, Valerie ,  DIETRICH, Pierre-Yves ,  ZOETE, Vincent ,  IWASZKIEWICZ, Justyna ,  MICHIELIN, Olivier ,  POSEY, Avery

IPC分类号： A61P35/00 ,  A61K38/00 ,  A61K48/00 ,  A61P35/02 ,  C07K14/53 ,  C12N9/64 ,  C12N15/62

CPC分类号： C07K14/53 ,  C12N9/6467 ,  A61P35/00 ,  A61P35/02 ,  A61K38/00 ,  C12Y304/21079 ,  C07K2319/0020130101 ,  C07K2319/4320130101 ,  C07K2319/0220130101 ,  C07K2319/5020130101

公开(公告)号：EP3452102B9

公开(公告)日：2024-09-04

申请号：EP17734159.1

申请日：2017-04-13

IPC分类号： A61K48/00 ,  C12N15/86 ,  C07K14/755

CPC分类号： A61K48/0058 ,  C12N15/86 ,  C12N2750/1413220130101 ,  A61P7/04

公开(公告)号：EP4420663A2

公开(公告)日：2024-08-28

申请号：EP24173692.5

申请日：2014-12-19

申请人： Novartis AG ,  The Trustees of The University of Pennsylvania

发明人： BROGDON, Jennifer ,  ENGELS, Boris ,  GLASS, David Jonathan ,  GRANDA, Brian ,  HASTEWELL, John ,  LOEW, Andreas ,  MANNICK, Joan ,  MILONE, Michael ,  MURPHY, Leon ,  SELLERS, William Raj ,  SONG, Huijuan ,  VASH, Brian Edward ,  WEILER, Jan ,  WU, Qilong ,  ZHOU, Li

IPC分类号： A61K31/436

CPC分类号： C07K14/7051 ,  C07K14/70521 ,  C07K14/70539 ,  C07K14/70578 ,  C12N9/90 ,  C07K2319/0020130101 ,  C07K2319/0320130101 ,  C07K2319/7020130101 ,  C12N9/1205 ,  C07K2319/4120130101 ,  C07K2319/4320130101 ,  A61K31/436 ,  C12Y502/00 ,  A61P35/00 ,  A61P37/04 ,  A61K39/464468 ,  A61K2239/2420230501 ,  A61K2239/4820230501 ,  A61K39/4631 ,  A61K39/464404 ,  A61K2239/2320230501 ,  A61K39/4611 ,  A61K2239/3820230501 ,  A61K39/464412

摘要： Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.

公开(公告)号：EP4408436A1

公开(公告)日：2024-08-07

申请号：EP22877521.9

申请日：2022-09-28

申请人： The Trustees of The University of Pennsylvania

发明人： MITCHELL, Michael ,  BILLINGSLEY, Margaret M.

IPC分类号： A61K31/7088 ,  A61K9/107 ,  A61K9/127 ,  A61K9/51 ,  A61K47/54 ,  A61P31/04 ,  A61P35/00 ,  C07C215/08

CPC分类号： A61K9/1271 ,  A61K9/0019 ,  A61K47/543 ,  A61K47/6929 ,  A61K47/6835 ,  A61K45/06

公开(公告)号：EP3747998B1

公开(公告)日：2024-07-24

申请号：EP20170476.4

申请日：2014-03-13

IPC分类号： C12N7/00 ,  C12N7/01 ,  C12N15/00 ,  A61K48/00 ,  C12N9/24 ,  A61P43/00

CPC分类号： C12Y302/01076 ,  C12N9/2402 ,  A61K48/0058 ,  C12N2750/1414320130101 ,  A61P43/00

公开(公告)号：EP4400510A2

公开(公告)日：2024-07-17

申请号：EP24158688.2

申请日：2007-07-30

申请人： The Trustees of the University of Pennsylvania

发明人： Weiner, David B. ,  Yan, Jian

IPC分类号： C07K14/00

CPC分类号： C12N2740/1612220130101 ,  C12N2740/1613420130101 ,  C12N2740/1622220130101 ,  C12N2740/1623420130101 ,  C12N2740/1632220130101 ,  C12N2740/1633420130101 ,  A61K39/12 ,  A61K2039/52320130101 ,  A61K2039/5320130101 ,  C12N2710/2003420130101 ,  C12N2760/1613420130101 ,  C12N2770/2423420130101 ,  A61K38/00 ,  A61K2039/5420130101 ,  A61K2039/5553820130101 ,  A61K2039/58520130101 ,  C07K14/005 ,  A61P15/00 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P31/20 ,  A61P35/00 ,  A61P37/04 ,  A61K39/001157 ,  A61K39/00 ,  A61K39/4611 ,  A61K39/0011 ,  A61K39/464838

摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences for HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.

公开(公告)号：EP4373080A1

公开(公告)日：2024-05-22

申请号：EP24152686.2

申请日：2014-10-24

申请人： The Children's Hospital of Philadelphia ,  The Trustees of The University of Pennsylvania

发明人： HIGH, Katherine A. ,  BENNETT, Jean ,  CHUNG, Daniel ,  MAGUIRE, Albert ,  WELLMAN, Jennifer ,  MCCAGUE, Sarah ,  PODSAKOFF, Gregory

IPC分类号： H04N17/00 ,  A61B5/00 ,  A61B5/11 ,  A61B3/00 ,  A61B3/06

CPC分类号： A61B3/0041 ,  A61B3/0008 ,  A61B3/063

摘要： A test of visual function and/or functional vision may be performed at varying luminance levels. A first course may be selected for a subject. A given course may comprise a layout having a beginning point, at least one turn, at least one obstacle, and an ending point. The first course may be illuminated with a first luminance level based on an estimated lower light sensitivity cutoff. The subject may be prompted to perform a first run of the test. The test may comprise, from the beginning point to the ending point, navigating the layout of the first course by walking around the at least one turn and avoiding the at least one obstacle. A determination may be made as to whether the subject successfully completed the first course based on one or both of speed or accuracy.

公开(公告)号：EP4372002A2

公开(公告)日：2024-05-22

申请号：EP24152127.7

申请日：2017-09-14

申请人： The Trustees of The University of Pennsylvania

发明人： TSOURKAS, Andrew ,  ALTUN, Burcin ,  WANG, Hejia Henry ,  YU, Feifan

IPC分类号： C07K16/00

CPC分类号： C07K19/00 ,  C07K2319/2020130101 ,  C07K2319/3020130101 ,  C12N9/52 ,  C07K16/00 ,  C07K2317/62220130101 ,  C07K16/2809 ,  C07K7/06

摘要： The invention relates to proximity-based sortase-mediated protein purification and ligation. More specifically, the invention relates to compositions and techniques that link protein expression/purification with conjugation to therapeutic agents, imaging agents or linkers.