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    NOVEL CARTILAGE CELL PROLIFERATION AND DIFFERENTIATION INDUCER
    5.
    发明公开
    NOVEL CARTILAGE CELL PROLIFERATION AND DIFFERENTIATION INDUCER 有权
    新型肉碱细胞程序设计与鉴别诱导因子

    公开(公告)号：EP2343087A4

    公开(公告)日：2012-08-01

    申请号：EP09817647

    申请日：2009-09-09

    申请人： ORIENTAL YEAST CO LTD

    发明人： YASUDA HISATAKA ,  FURUYA YURIKO

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6887 ,  A61K38/08 ,  A61K38/1841 ,  A61K38/1875 ,  A61K38/191 ,  C07K2319/00 ,  C12N5/06 ,  C12N2506/00 ,  G01N2333/70575 ,  G01N2500/10

    摘要： This invention provides a method for administration of an effective amount of RANKL-binding molecules that act on prechondrocytes and/or mesenchymal stem cells, accelerate cartilage differentiation, proliferation, and maturation of such cells, enhance chondrocyte differentiation, and induce chondrocyte proliferation to induce chondrocyte proliferation and differentiation or increase cartilage matrix production and a pharmaceutical composition used for inducing chondrocyte proliferation and differentiation or increasing cartilage matrix production. The pharmaceutical composition used for treatment or prevention of a chondropathies comprises, as an active ingredient, a compound that acts on prechondrocytes and/or mesenchymal stem cells and induces at least one of the following: (a) acceleration of prechondrocyte and/or mesenchymal stem cell differentiation; (b) acceleration of prechondrocyte and/or mesenchymal stem cell proliferation; (c) acceleration of prechondrocyte and/or mesenchymal stem cell maturation; (d) enhancement of chondrocyte differentiation; (e) chondrocyte proliferation; and (f) increased production of the cartilage matrix.

    Methods using an osteopenia animal model
    6.
    发明公开
    Methods using an osteopenia animal model 审中-公开
    Methoden unter Verwendung eines tierischen Osteopenie-Modells

    公开(公告)号：EP2389803A2

    公开(公告)日：2011-11-30

    申请号：EP11169483.2

    申请日：2007-10-11

    申请人： ORIENTAL YEAST CO., LTD.

    发明人： Tomimori, Yoshiya ,  Yasuda, Hisataka

    IPC分类号： A01K67/027 ,  A01K67/00 ,  G01N33/15 ,  G01N33/50 ,  C07K14/47

    CPC分类号： C07K14/4705 ,  A01K2207/10 ,  A01K2227/105 ,  A01K2267/03 ,  C07K2319/23 ,  G01N33/5088 ,  G01N2333/70575 ,  G01N2800/108

    摘要： The present invention provides a method for producing an osteopenia animal model by RANKL administration and an osteopenia animal model.
    Also, a method for producing an osteopenia animal model, comprising administering, soluble RANKL or a fused protein of soluble RANKL with an epitope tag to a non-human animal so as to promote in vivo osteoclast differentiation and activation in the non-human animal, and an osteopenia animal model produced by the method are provided.

    摘要翻译： 本发明提供了一种通过RANKL给药和骨质减少动物模型生产骨质减少症动物模型的方法。 另外，一种生产骨质减少症动物模型的方法，包括向非人动物施用可溶性RANKL或具有表位标签的可溶性RANKL融合蛋白，以促进非人动物体内破骨细胞分化和活化， 并提供通过该方法产生的骨质减少动物模型。

    METHOD OF DETECTING MAMMARY CANCER CELLS
    9.
    发明公开
    METHOD OF DETECTING MAMMARY CANCER CELLS 审中-公开
    检测方法的乳腺癌细胞

    公开(公告)号：EP2128621A4

    公开(公告)日：2011-05-18

    申请号：EP07707909

    申请日：2007-02-01

    申请人： ORIENTAL YEAST CO LTD

    发明人： KINUGASA MASAHIRO ,  SUGIMOTO MICHIYO ,  UCHIDA KOJI

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57415

    摘要： The present invention provides a novel method for detecting mammary cancer cells which uses, as an index, an expression level of a specific gene in human mammary cancer tissue (or cells). The method is characterized by including (1) measuring an expression level of a gene having a specific nucleotide sequence in human mammary cancer tissue (or cells), (2) measuring an expression level of the gene in human normal mammary gland tissue (or cells), and (3) detecting mammary cancer cells on the basis of the difference between measurement values obtained in (1) and (2).