公开(公告)号：EP0730657B1

公开(公告)日：2008-04-30

申请号：EP95902161.9

申请日：1994-11-22

申请人： Aventis Pharma S.A. ,  INSTITUT PASTEUR ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： BEUZARD, Yves ,  DANOS, Olivier ,  DESCAMPS, Vincent ,  HEARD, Jean-Michel ,  MOULLIER, Philippe ,  NAFFAKH, Nadia ,  PERRICAUDET, Michel ,  VAINCHENKER, William

IPC分类号： C12N15/86 ,  C12N5/10 ,  A61K48/00

CPC分类号： A61K38/1816 ,  A61K48/00 ,  C07K14/505

摘要： The present invention provides cell compositions for in vivo implantation, and designed for the sustained and controlled delivery of therapeutic substances.

公开(公告)号：EP0730657A1

公开(公告)日：1996-09-11

申请号：EP95902161.0

申请日：1994-11-22

申请人： RHONE-POULENC RORER S.A. ,  INSTITUT PASTEUR ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： BEUZARD, Yves ,  DANOS, Olivier ,  DESCAMPS, Vincent ,  HEARD, Jean-Michel ,  MOULLIER, Philippe ,  NAFFAKH, Nadia ,  PERRICAUDET, Michel ,  VAINCHENKER, William

IPC分类号： C12N15 ,  A61K9 ,  A61K35 ,  A61K38 ,  A61K39 ,  A61K48 ,  A61P5 ,  A61P7 ,  A61P13 ,  A61P15 ,  A61P43 ,  C07H21 ,  C07K14 ,  C12N5

CPC分类号： A61K38/1816 ,  A61K48/00 ,  C07K14/505

摘要： The present invention provides cell compositions for in vivo implantation, and designed for the sustained and controlled delivery of therapeutic substances.

公开(公告)号：EP4179091A1

公开(公告)日：2023-05-17

申请号：EP21749482.2

申请日：2021-07-09

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM ,  Université d'Aix-Marseille ,  Université de Bordeaux ,  RegenxBio Inc. ,  Centre National de la Recherche Scientifique ,  Corlieve Therapeutics

发明人： CREPEL, Valérie ,  MULLE, Christophe ,  BOILEAU, Céline ,  DEFORGES, Séverine ,  DANOS, Olivier ,  MERCER, Andrew ,  PORTER, Richard ,  TEPE, April R.

IPC分类号： C12N15/113

公开(公告)号：EP0201540B2

公开(公告)日：2001-10-31

申请号：EP85905513.9

申请日：1985-10-18

申请人： INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： MONTAGNIER, Luc ,  KRUST, Bernard ,  CHAMARET, Solange ,  CLAVEL, François ,  CHERMANN, Jean-Claude ,  BARRE-SINOUSSI, Françoise ,  ALIZON, Marc ,  SONIGO, Pierre ,  STEWART, Cole ,  DANOS, Olivier ,  WAIN-HOBSON, Simon

IPC分类号： C07K14/16

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K16/1054 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12Q1/702 ,  C12Q1/703 ,  G01N33/531

摘要： Purified expression products of DNA sequences derived of the genome of the LAV virus. It relates more particularly to a glycoprotein having a molecular weight of about 110,000 or antigen of lower molecular weight derived from the preceding one, which purified product possesses the capacity of being recognised by serums of human origin and containing antibodies against the LAV virus. It also relates to other purified polypeptides derived either from the abovesaid glycoprotein or of core proteins of LAV virus. The glycoprotein can be used for the production of immunogenic composition capable of neutralizing the LAV virus. All of the abovesaid glycoprotein or polypeptides can be used as antigens useful in the diagnosis of LAV antibodies in sera of patients.

公开(公告)号：EP0201540B1

公开(公告)日：1991-06-19

申请号：EP85905513.9

申请日：1985-10-18

申请人： INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： MONTAGNIER, Luc ,  KRUST, Bernard ,  CHAMARET, Solange ,  CLAVEL, François ,  CHERMANN, Jean-Claude ,  BARRE-SINOUSSI, Françoise ,  ALIZON, Marc ,  SONIGO, Pierre ,  STEWART, Cole ,  DANOS, Olivier ,  WAIN-HOBSON, Simon

IPC分类号： C07K13/00 ,  C07K3/00 ,  C12N15/49 ,  G01N33/569 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K16/1054 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12Q1/702 ,  C12Q1/703 ,  G01N33/531

摘要： Purified expression products of DNA sequences derived of the genome of the LAV virus. It relates more particularly to a glycoprotein having a molecular weight of about 110,000 or antigen of lower molecular weight derived from the preceding one, which purified product possesses the capacity of being recognised by serums of human origin and containing antibodies against the LAV virus. It also relates to other purified polypeptides derived either from the abovesaid glycoprotein or of core proteins of LAV virus. The glycoprotein can be used for the production of immunogenic composition capable of neutralizing the LAV virus. All of the abovesaid glycoprotein or polypeptides can be used as antigens useful in the diagnosis of LAV antibodies in sera of patients.

公开(公告)号：EP0104217B1

公开(公告)日：1988-09-14

申请号：EP83901081.6

申请日：1983-04-01

申请人： INSTITUT PASTEUR

发明人： DANOS, Olivier ,  KATINKA, Michael ,  YANIV, Moshe

IPC分类号： C12N15/00 ,  C12P21/02 ,  A61K39/12 ,  C07K7/00 ,  C07K1/00 ,  G01N33/53

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/42 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12Q1/708 ,  G01N33/569

摘要： DNA fragment of which the expression product in an appropriate micro organism comprises at least one of the antigenic determinants of the papillomavirus. It is characterized in that it comprises a neucleotide sequence, which is itself contained or similar to that which is contained either in L1 area or L2 area, or alternatingly partly in L1 area and partly in L2 area of the one strand among the papillomavirus genom strands which comprises them and which are capable of coding for virus structure proteines or for polypeptides having in common with those proteins a sequence containing at least one antigenic determinant characteristic of the papillomavirus.

公开(公告)号：EP0702723A1

公开(公告)日：1996-03-27

申请号：EP94914431.0

申请日：1994-04-21

申请人： INSTITUT PASTEUR

发明人： MOULLIER, Philippe ,  DANOS, Olivier ,  HEARD, Jean-Michel ,  FERRY, Nicolas

IPC分类号： C12N15 ,  A61K9 ,  A61K31 ,  A61K35 ,  A61K47 ,  A61K48 ,  A61L27 ,  A61P7 ,  A61P31 ,  C07K14 ,  C12N5 ,  C12N9 ,  A61K38 ,  C12R1

CPC分类号： A61K9/0024 ,  A61K35/12 ,  A61K38/00 ,  A61K48/00 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  C07K14/505 ,  C07K14/721 ,  C12N5/0068 ,  C12N9/10 ,  C12N9/1051 ,  C12N9/2402 ,  C12N15/86 ,  C12N2510/02 ,  C12N2533/18 ,  C12N2533/30 ,  C12N2533/54 ,  C12N2740/13043 ,  C12N2740/16043 ,  C12Y204/01017 ,  C12Y302/01031 ,  C12Y302/01076

摘要： The invention relates to an implant obtained by assembling in vitro various elements in order to form a neo-organ which is introduced preferably in the peritoneal cavity of the recipient. The implant comprises a biocompatible support intended to the biological anchoring of cells; cells having the capacity of expressing and secreting naturally or after recombination a predetermined compound, for example a compound having a therapeutical interest; and a constituent capable of inducing and/or promoting the geling of said cells. The invention also relates to a kit for the preparation of the implant as well as to a new recombinant retroviral vector comprising a provirus DNA sequence modified in that the genes gag, pol and env have been deleted at least partially so as to obtain a proviral DNA capable of replication. The invention also relates to recombinant cells comprising the new retroviral vector.

公开(公告)号：EP0201540A1

公开(公告)日：1986-11-20

申请号：EP85905513.0

申请日：1985-10-18

申请人： INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： MONTAGNIER, Luc ,  KRUST, Bernard ,  CHAMARET, Solange ,  CLAVEL, François ,  CHERMANN, Jean-Claude ,  BARRE-SINOUSSI, Françoise ,  ALIZON, Marc ,  SONIGO, Pierre ,  STEWART, Cole ,  DANOS, Olivier ,  WAIN-HOBSON, Simon

IPC分类号： G01N33 ,  A61K39 ,  A61P31 ,  C07H21 ,  C07K1 ,  C07K7 ,  C07K14 ,  C07K16 ,  C12N15 ,  C12P21 ,  C12Q1 ,  A61K38 ,  C12R1

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K16/1054 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12Q1/702 ,  C12Q1/703 ,  G01N33/531

摘要： Produits purifiés d'expression de séquences d'ADN dérivées du génome du virus LAV. On décrit particulièrement une glycoprotéine possédant un poids moléculaire d'environ 110 000 ou un antigène de poids moléculaire inférieur dérivé de ladite glycoprotéine, ce produit purifié pouvant être reconnu par des sérums d'origine humaine et contenant des anticorps contre le virus LAV. L'invention se rapporte également à d'autres polypeptides purifiés dérivés soit de ladite glycoprotéine soit de protéines de noyau du virus LAV. La glycoprotéine peut être utilisée pour la production de compositions immunogènes pouvant neutraliser le virus LAV. La glycoprotéine ou les polypeptides ci-décrits peuvent être utilisés comme antigènes utiles dans le diagnostic d'anticorps du LAV dans les sérum prélevés chez les patients.

公开(公告)号：EP0104217A1

公开(公告)日：1984-04-04

申请号：EP83901081.0

申请日：1983-04-01

申请人： INSTITUT PASTEUR

发明人： DANOS, Olivier ,  KATINKA, Michael ,  YANIV, Moshe

IPC分类号： C12N15 ,  A61K39 ,  A61P31 ,  C07H21 ,  C07K14 ,  C07K16 ,  C07K19 ,  C12P21 ,  C12Q1 ,  G01N33

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/42 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12Q1/708 ,  G01N33/569

摘要： Fragment d'ADN dont le produit d'expression dans un micro-organisme approprié contient au moins l'un des déterminants antigéniques des papillomavirus. Il est caractérisé en ce qu'il comporte une séquence de nucléotides, elle-même contenue ou analogue à celle contenue soit dans la région L1, soit dans la région L2, soit encore pour partie dans la région L1 et pour partie dans la région L2 de celui des brins du génome de papillomavirus qui les comporte et qui sont capables de coder pour des protéines de structure du virus ou pour des polypeptides ayant en commun avec ces protéines une séquence contenant au moins un déterminant antigénique caractéristique des papillomavirus

公开(公告)号：EP0702723B1

公开(公告)日：2002-09-04

申请号：EP94914431.5

申请日：1994-04-21

申请人： INSTITUT PASTEUR

发明人： MOULLIER, Philippe ,  DANOS, Olivier ,  HEARD, Jean-Michel ,  FERRY, Nicolas

IPC分类号： C12N15/86 ,  A61K48/00 ,  C12N5/10 ,  A61L27/00 ,  A61K9/14 ,  C12N9/24 ,  C12N15/27 ,  C12N9/12 ,  C12N15/12 ,  C12N15/56 ,  C12N15/54

CPC分类号： A61K9/0024 ,  A61K35/12 ,  A61K38/00 ,  A61K48/00 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  C07K14/505 ,  C07K14/721 ,  C12N5/0068 ,  C12N9/10 ,  C12N9/1051 ,  C12N9/2402 ,  C12N15/86 ,  C12N2510/02 ,  C12N2533/18 ,  C12N2533/30 ,  C12N2533/54 ,  C12N2740/13043 ,  C12N2740/16043 ,  C12Y204/01017 ,  C12Y302/01031 ,  C12Y302/01076

摘要： The invention relates to an implant obtained by assembling in vitro various elements in order to form a neo-organ which is introduced preferably in the peritoneal cavity of the recipient. The implant comprises a biocompatible support intended to the biological anchoring of cells; cells having the capacity of expressing and secreting naturally or after recombination a predetermined compound, for example a compound having a therapeutical interest; and a constituent capable of inducing and/or promoting the geling of said cells. The invention also relates to a kit for the preparation of the implant as well as to a new recombinant retroviral vector comprising a provirus DNA sequence modified in that the genes gag, pol and env have been deleted at least partially so as to obtain a proviral DNA capable of replication. The invention also relates to recombinant cells comprising the new retroviral vector.