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公开(公告)号：EP3063150A1
公开(公告)日：2016-09-07
申请号：EP14789580.9
申请日：2014-10-28
发明人： RÖHRIG, Susanne , HILLISCH, Alexander , STRASSBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina, Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , TELLER, Henrik , JIMENEZ NUNEZ, Eloisa , SCHIROK, Hartmut , KLAR, Jürgen
IPC分类号： C07D487/04 , A61K31/4188 , A61P7/02
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： The invention relates to substituted oxopyridine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicinal drugs for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases. The oxopyridine derivatives inhibit factor XIa and plasma kallicrein.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及odemas以及眼科疾病的药物的用途 。
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公开(公告)号：EP3558960A1
公开(公告)日：2019-10-30
申请号：EP17826197.0
申请日：2017-12-18
发明人： BÄURLE, Stefan , DAVENPORT, Adam, James , STIMSON, Christopher , NAGEL, Jens , SCHMIDT, Nicole , ROTGERI, Andrea , GRÖTICKE, Ina , RAUSCH, Alexandra , KLAR, Jürgen , DYRKS, Thomas
IPC分类号： C07D333/58 , C07D231/12 , C07D231/56 , C07D333/28 , C07D333/38 , C07D233/64 , C07D241/12 , C07D495/04 , C07D277/56 , C07D213/56 , A61K31/415 , A61P29/00
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公开(公告)号：EP3063150B1
公开(公告)日：2017-11-22
申请号：EP14789580.9
申请日：2014-10-28
发明人： RÖHRIG, Susanne , HILLISCH, Alexander , STRASSBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina, Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , TELLER, Henrik , JIMENEZ NUNEZ, Eloisa , SCHIROK, Hartmut , KLAR, Jürgen
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
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4.发明公开SUBSTITUIERTE OXOPYRIDIN-DERIVATE UND IHRE VERWENDUNG BEI DER BEHANDLUNG VON HERZ-KREISLAUF-ERKRANKUNGEN 审中-公开取代氧吡啶衍生物及其在心血管疾病的治疗
公开(公告)号：EP2978756A1
公开(公告)日：2016-02-03
申请号：EP14713452.2
申请日：2014-03-27
发明人： RÖHRIG, Susanne , HILLISCH, Alexander , STRAßBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , KINZEL, Tom , TELLER, Henrik , SCHIROK, Hartmut , KLAR, Jürgen , JIMENEZ NUNEZ, Eloisa
IPC分类号： C07D413/14 , C07D213/85 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/12 , C07D417/12 , C07D213/64 , C07D213/69 , A61K31/4427 , A61K31/4412 , A61K31/4418 , A61P7/00 , A61P9/00
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives of the formula in which R
1 is a group of the formula, where * is the attachment site to the oxopyridine ring, R
6 is bromine, chlorine, fluorine, methyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy or trifluoromethoxy, R
7 is bromine, chlorine, fluorine, cyano, nitro, hydroxyl, methyl, difluoromethyl, trifluoromethyl, methoxy, ethoxy, difluoromethoxy, trifluoromethoxy, ethynyl, 3,3,3-trifluoroprop-l-yn-l-yl or cyclopropyl, and to processes for preparation thereof and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular diseases, preferably thrombotic or thromboembolic diseases and of oedemas, and also of ophthalmological disorders.摘要翻译： 本发明涉及substituiertem氧代吡啶衍生物和它们的制备方法，并因此它们用于制备药物用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性病症，和水肿，因此眼科疾病使用 ，
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公开(公告)号：EP2978756B1
公开(公告)日：2019-03-27
申请号：EP14713452.2
申请日：2014-03-27
发明人： RÖHRIG, Susanne , HILLISCH, Alexander , STRAßBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , KINZEL, Tom , TELLER, Henrik , SCHIROK, Hartmut , KLAR, Jürgen , JIMENEZ NUNEZ, Eloisa
IPC分类号： C07D413/14 , C07D213/85 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/12 , C07D417/12 , C07D213/64 , C07D213/69 , A61K31/4427 , A61K31/4412 , A61K31/4418 , A61P7/00 , A61P9/00
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6.发明公开SUBSTITUIERTE BIPIPERIDINYL-DERIVATE ALS ADRENOREZEPTOR ALPHA 2C ANTAGONISTEN 审中-公开取代联哌啶衍生物作为支撑ALPHA 2C受体拮抗剂
公开(公告)号：EP3083594A1
公开(公告)日：2016-10-26
申请号：EP14815662.3
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GNOTH, Mark Jean , HIMMEL, Herbert , KAST, Raimund , KLAR, Jürgen , KNORR, Andreas , LANG, Dieter , LINDNER, Niels , SCHMECK, Carsten , SCHOHE-LOOP, Rudolf , TINEL, Hanna , TRÜBEL, Hubert , WUNDER, Frank
IPC分类号： C07D401/14 , C07D211/16 , C07D211/22 , C07D211/42 , C07D401/12 , C07D403/04 , C07D413/04 , C07D413/10 , C07D413/12 , A61K31/4468 , A61K31/4523 , A61P3/10 , A61P9/00
CPC分类号： C07D211/10 , A61K31/4545 , A61K45/06 , C07D211/16 , C07D211/22 , C07D211/42 , C07D211/60 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, especially for promotion of wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulation disorders, Raynaud phenomena, CREST syndrome, microcirculation disorders, intermittent claudication, and peripheral and autonomous neuropathies.
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7.发明授权HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS 有权HYDROXYMETHYLARYL-取代的吡咯并三ALK1抑制剂
公开(公告)号：EP2726482B1
公开(公告)日：2016-07-20
申请号：EP12730515.9
申请日：2012-06-26
发明人： KLAR, Jürgen , VOEHRINGER, Verena , TELSER, Joachim , LOBELL, Mario , SÜßMEIER, Frank , LI, Volkhart Min-Jian , BÖTTGER, Michael , GOLZ, Stefan , LANG, Dieter , SCHLEMMER, Karl-Heinz , SCHLANGE, Thomas , SCHALL, Andreas , FU, Wenlang
IPC分类号： C07D487/04 , A61K31/53 , A61P27/00
CPC分类号： A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
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公开(公告)号：EP3526212A1
公开(公告)日：2019-08-21
申请号：EP17780751.8
申请日：2017-10-09
发明人： GIESE, Anja , KLAR, Jürgen , EHRMANN, Alexander Helmut Michael , WILLWACHER, Jens , ENGEL, David , DIESKAU, Andre Philippe , KAHNERT, Antje , GROMOV, Alexey , SCHMECK, Carsten , LINDNER, Niels , MÜLLER, Thomas , ANDREEVSKI, Anna Lena , DREHER, Jan , COLLINS, Karl
IPC分类号： C07D403/14 , C07D471/04 , C07D487/04 , C07D413/14 , A61K31/506 , A61K31/5377 , A61P13/12
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9.发明公开SUBSTITUIERTE PYRIDOBENZODIAZEPINON-DERIVATE UND IHRE VERWENDUNG 审中-公开SUBSTITUIERTE PYRIDOBENZODIAZEPINON-DERIVATE和IHRE VERWENDUNG
公开(公告)号：EP3223821A1
公开(公告)日：2017-10-04
申请号：EP15797685.3
申请日：2015-11-23
发明人： SCHALL, Andreas , KLAR, Jürgen , LOBELL, Mario , SCHIROK, Hartmut , TELSER, Joachim , MÜLLER, Steffen , BROHM, Dirk , BRIEM, Hans , JÖRISSEN, Hannah , BÖTTGER, Michael , DEGENFELD VON, Georges , SCHLANGE, Thomas , BÖMER, Ulf , LINDNER, Niels , EILKEN, Hanna , HRISTODOROV, Dmitrij , WASNAIRE, Pierre , GERICKE, Kersten Matthias , BÄRFACKER, Lars
IPC分类号： A61K31/5513 , A61P27/02 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5513 , A61K39/39558
摘要： The invention relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-
b ]-[1,5]benzodiazepine-5-one-derivatives, to methods for the production thereof, use thereof alone or in combination for treating and/or for preventing diseases and use thereof in producing medicaments for treating and/or preventing diseases, especially angiogenic disorders and hyperproliferative disorders with a neovascularization component, such as opthalmologic disorders such as cancers and tumor diseases. Such treatments can be carried out as monotherapy or also in combination with other medicaments or additional therapeutic measures.摘要翻译： 本申请涉及新的（3-羟基苯基）氨基取代的吡啶并[2,3-b] [1,5]苯并二氮杂-5-酮衍生物，涉及其制备方法，其单独或组合用于治疗 和/或预防疾病及其用于制备用于治疗和/或预防疾病，尤其是新生血管形成起作用的血管生成病症和过度增殖性疾病（例如眼科疾病和癌症和肿瘤）的药物的用途。 这些治疗可以作为单一疗法或者与其他药物或其他治疗措施组合进行。
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10.发明公开HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS 有权HYDROXYMETHYLARYL-取代的吡咯并三ALK1抑制剂
公开(公告)号：EP2726482A1
公开(公告)日：2014-05-07
申请号：EP12730515.9
申请日：2012-06-26
发明人： KLAR, Jürgen , VOEHRINGER, Verena , TELSER, Joachim , LOBELL, Mario , SÜßMEIER, Frank , LI, Volkhart Min-Jian , BÖTTGER, Michael , GOLZ, Stefan , LANG, Dieter , SCHLEMMER, Karl-Heinz , SCHLANGE, Thomas , SCHALL, Andreas , FU, Wenlang
IPC分类号： C07D487/04 , A61K31/53 , A61P27/00
CPC分类号： A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
摘要： This invention relates to novel 5-[(hydroxymethyl)aryl] -substituted pyrrolo[2, 1-f][1, 2, 4] triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.
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