公开(公告)号：EP2408751A1

公开(公告)日：2012-01-25

申请号：EP10709419.5

申请日：2010-03-12

申请人： Bayer Pharma Aktiengesellschaft

发明人： BRÜGGEMEIER, Ulf ,  FÜRSTNER, Chantal ,  GEISS, Volker ,  KELDENICH, Jörg ,  KERN, Armin ,  DELBECK, Martina ,  KOLKHOF, Peter ,  KRETSCHMER, Axel ,  POOK, Elisabeth ,  SCHMECK, Carsten ,  TRÜBEL, Hubert

IPC分类号： C07D233/70 ,  C07D249/12 ,  C07D409/04 ,  C07D413/12 ,  A61K31/4166 ,  A61K31/4196 ,  A61K31/422 ,  A61P9/00

CPC分类号： C07D233/70 ,  A61K9/0095 ,  A61K9/2054 ,  A61K31/4166 ,  A61K31/4196 ,  A61K31/422 ,  A61K45/06 ,  C07D249/12 ,  C07D409/04 ,  C07D413/12 ,  A61K2300/00

摘要： The invention relates to novel, substituted 2-acetamido-5-aryl-1,2,4-triazolones, to methods for producing the same, to the use thereof either alone or in combination in the treatment and/or prevention of diseases and to their use for producing drugs for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular diseases.

摘要翻译： 本申请涉及新的取代的2-乙酰氨基-5-芳基-1,2,4-三唑酮，用于制备它们的方法，单独使用或组合用于治疗和/或预防疾病，以及它们 用于生产用于治疗和/或预防疾病的药物，更具体地用于治疗和/或预防心血管疾病。

公开(公告)号：EP3083594A1

公开(公告)日：2016-10-26

申请号：EP14815662.3

申请日：2014-12-16

申请人： Bayer Pharma Aktiengesellschaft

发明人： BECKER-PELSTER, Eva Maria ,  BUCHGRABER, Philipp ,  BUCHMÜLLER, Anja ,  ENGEL, Karen ,  GNOTH, Mark Jean ,  HIMMEL, Herbert ,  KAST, Raimund ,  KLAR, Jürgen ,  KNORR, Andreas ,  LANG, Dieter ,  LINDNER, Niels ,  SCHMECK, Carsten ,  SCHOHE-LOOP, Rudolf ,  TINEL, Hanna ,  TRÜBEL, Hubert ,  WUNDER, Frank

IPC分类号： C07D401/14 ,  C07D211/16 ,  C07D211/22 ,  C07D211/42 ,  C07D401/12 ,  C07D403/04 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  A61K31/4468 ,  A61K31/4523 ,  A61P3/10 ,  A61P9/00

CPC分类号： C07D211/10 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/16 ,  C07D211/22 ,  C07D211/42 ,  C07D211/60 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14

摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, especially for promotion of wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulation disorders, Raynaud phenomena, CREST syndrome, microcirculation disorders, intermittent claudication, and peripheral and autonomous neuropathies.

公开(公告)号：EP2470530A1

公开(公告)日：2012-07-04

申请号：EP10745249.2

申请日：2010-08-24

申请人： Bayer Pharma Aktiengesellschaft

发明人： FÜRSTNER, Chantal ,  KELDENICH, Jörg ,  KERN, Armin ,  DELBECK, Martina ,  KOLKHOF, Peter ,  KRETSCHMER, Axel ,  POOK, Elisabeth ,  SCHMECK, Carsten ,  TRÜBEL, Hubert

IPC分类号： C07D413/12 ,  C07D403/12 ,  C07D401/12 ,  A61K31/4245 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4439 ,  A61P5/12 ,  A61P7/10 ,  A61P9/00

CPC分类号： C07D413/12 ,  C07D401/12 ,  C07D403/12

摘要： The present application relates to novel heterocyclic-substituted 1-carboylmethyl-3-aryl-1,2,4-triazol-5-ones, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular disorders. The compounds are vasopressin receptor antagonists.

公开(公告)号：EP2408754A1

公开(公告)日：2012-01-25

申请号：EP10707478.3

申请日：2010-03-09

申请人： Bayer Pharma Aktiengesellschaft

发明人： BRÜGGEMEIER, Ulf ,  FÜRSTNER, Chantal ,  GEISS, Volker ,  KELDENICH, Joerg ,  KERN, Armin ,  DELBECK, Martina ,  KOLKHOF, Peter ,  KRETSCHMER, Axel ,  POOK, Elisabeth ,  SCHMECK, Carsten ,  TRÜBEL, Hubert

IPC分类号： C07D249/12 ,  A61K31/4196 ,  A61P9/04 ,  A61P1/16

CPC分类号： C07D249/12

摘要： The present application relates to novel substituted phenylalanine derivatives, to methods for the production thereof, to the use thereof alone or in combination to treat and/or prevent illnesses, and to the use thereof to produce drugs for treating and/or preventing illnesses, in particular for treating and/or preventing cardiovascular diseases.