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公开(公告)号：EP2776409B1
公开(公告)日：2016-02-03
申请号：EP12787341.2
申请日：2012-11-09
发明人： SEIGAL, Benjamin, Adam , TERRETT, Nicholas , CARTER, Percy, H. , BORZILLERI, Robert, M. , ZHANG, Yong , MILLER, Michael, M.
IPC分类号： C07D249/04 , A61P35/00
CPC分类号： C07D498/22 , A61K38/00 , C07D249/04 , C07D498/16 , C07K5/1008 , C07K7/56 , Y02A50/411 , Y02A50/414
摘要： The invention relates generally to macrocyclic compounds and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of inhibitors of apoptosis (IAPs) and/or are useful in the treatment of medical conditions, such as cancer.
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公开(公告)号：EP1543009A1
公开(公告)日：2005-06-22
申请号：EP03767116.1
申请日：2003-08-04
IPC分类号： C07D487/04 , A61K31/53 , A61P13/08 , A61P29/00 , A61P37/00
CPC分类号： C07D487/04 , A61K31/53 , A61K45/06 , A61K2300/00
摘要： The present invention provides compounds of formula I, (I) and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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公开(公告)号：EP1513818A2
公开(公告)日：2005-03-16
申请号：EP03761106.8
申请日：2003-06-18
发明人： BORZILLERI, Robert, M. , TOKARSKI, John, S. , BHIDE, Rajeev, S. , ZHENG, Peter , QIAN, Ligang , CAI, Zhen-Wei
IPC分类号： C07D233/70 , C07D233/84 , C07C233/88 , C07D263/38 , C07D263/46 , C07D263/48 , C07D277/34 , C07D277/36 , C07D277/38 , A61K31/42 , A61P35/00
CPC分类号： C07D277/42 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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公开(公告)号：EP1073654A1
公开(公告)日：2001-02-07
申请号：EP99917475.8
申请日：1999-04-14
IPC分类号： C07D417/06
CPC分类号： C07D491/04 , A61K31/438 , A61K31/5513 , A61K31/5517
摘要： The present invention relates to 2,3-olefinic epothilone derivatives, methods of preparation of the derivatives and intermediates thereof.
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公开(公告)号：EP2776409A1
公开(公告)日：2014-09-17
申请号：EP12787341.2
申请日：2012-11-09
发明人： SEIGAL, Benjamin, Adam , TERRETT, Nicholas , CARTER, Percy, H. , BORZILLERI, Robert, M. , ZHANG, Yong , MILLER, Michael, M.
IPC分类号： C07D249/04 , A61P35/00
CPC分类号： C07D498/22 , A61K38/00 , C07D249/04 , C07D498/16 , C07K5/1008 , C07K7/56 , Y02A50/411 , Y02A50/414
摘要： The invention relates generally to macrocyclic compounds and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of inhibitors of apoptosis (IAPs) and/or are useful in the treatment of medical conditions, such as cancer.
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公开(公告)号：EP2235002A1
公开(公告)日：2010-10-06
申请号：EP09704457.2
申请日：2009-01-22
IPC分类号： C07D401/12 , C07D401/14 , A61K31/4427 , A61P35/00
CPC分类号： C07D401/14 , C07D401/12
摘要： Disclosed are compounds of Formula (I)and salts thereof. Also, disclosed are methods of using the compounds in the treatment of proliferative diseases, such as cancer, and to pharmaceutical compositions comprising at least one compound of Formula (I) or a pharmaceutically acceptable salt.
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公开(公告)号：EP1960403A1
公开(公告)日：2008-08-27
申请号：EP06846393.4
申请日：2006-11-29
IPC分类号： C07D487/04 , A61K31/549 , A61P35/00
CPC分类号： C07D487/04
摘要： In general, the instant invention comprises compounds having Formulae I and II: including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.
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公开(公告)号：EP1019389A2
公开(公告)日：2000-07-19
申请号：EP98930300.3
申请日：1998-06-16
IPC分类号： C07D313/00
CPC分类号： C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
摘要： The present invention relates to compounds of formula (V).
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9.发明授权
公开(公告)号：EP3245207B1
公开(公告)日：2019-08-21
申请号：EP16702266.4
申请日：2016-01-13
发明人： MCDONALD, Ivar, M. , CHOWDARI, Naidu, S. , JOHNSON, Walter, Lewis , ZHANG, Yong , BORZILLERI, Robert, M. , GANGWAR, Sanjeev
IPC分类号： C07D487/04 , C07D519/00 , A61K31/437 , A61P35/00
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公开(公告)号：EP3259264A1
公开(公告)日：2017-12-27
申请号：EP16711043.6
申请日：2016-02-15
发明人： DING, Pingyu , GELMAN, Marina , KINSELLA, Todd , SINGH, Rajinder , BHAMIDIPATI, Somasekhar , VELAPARTHI, Upender , BORZILLERI, Robert, M. , RAHAMAN, Hasibur , WARRIER, Jayakumar, Sankara
IPC分类号： C07D401/14 , C07D471/04 , C07D487/04 , A61K31/44 , A61P21/00
CPC分类号： C07D401/14 , C07B59/002 , C07B2200/05 , C07C53/06 , C07C53/18 , C07D471/04 , C07D487/04
摘要： and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, Z and n are as described herein. In certain embodiments, a compound disclosed herein inhibits GDF8, and can be used to treat disease by blocking GDF8 signaling.
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