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1.发明公开NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS 有权NEET CYCLISCHE AZABENZIMIDAZOLDERIVATE ALS ANTIDIABETIKA
公开(公告)号：EP2677869A4
公开(公告)日：2015-04-08
申请号：EP12749051
申请日：2012-02-23
申请人： MERCK SHARP & DOHME
发明人： ANAND RAJAN , APGAR JAMES M , BIFTU TESFAYE , CHEN PING , CHU LIN , COLANDREA VINCENT J , DONG GUIZHEN , DROPINSKI JAMES F , FENG DANQING , HICKS JACQUELINE D , JIANG JINLONG , KIM ALEXANDER J , LEAVITT KENNETH J , LI BING , QIAN XIAOXIA , SEBHAT IYASSU , WEI LAN , WILKENING ROBERT R , WU ZHICAI
IPC分类号： A01N43/58
CPC分类号： A61K31/5377 , A61K31/351 , A61K31/366 , A61K31/397 , A61K31/437 , A61K31/4412 , A61K31/496 , A61K31/4985 , A61K31/519 , A61K45/06 , C07D471/04 , C07D519/00 , A61K2300/00
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公开(公告)号：EP2906040A4
公开(公告)日：2016-07-06
申请号：EP13831487
申请日：2013-08-15
申请人： MERCK SHARP & DOHME
发明人： APGAR JAMES M , BIFTU TESFAYE , CHEN PING , FENG DANQING , HICKS JACQUELINE D , KEKEC AHMET , LEAVITT KENNETH J , LI BING , SEBHAT IYASSU , QIAN XIAOXIA , WEI LAN , WILKENING ROBERT R , WU ZHICAI
IPC分类号： A01N43/50 , A61K31/4184 , A61K31/4196 , A61K31/427 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14
CPC分类号： C07D417/14 , A61K31/4184 , A61K31/4196 , A61K31/427 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/12 , C07D405/14 , C07D413/14
摘要： Novel compounds described herein are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPKactivated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 本文所述的新型化合物是AMP-蛋白激酶的活化剂，并且可用于治疗，预防和抑制由AMPK激活的蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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公开(公告)号：EP2451285A4
公开(公告)日：2013-03-27
申请号：EP10797621
申请日：2010-06-28
申请人： MERCK SHARP & DOHME
发明人： OGAWA ANTHONY , UJJAINWALLA FEROZE , CHU LIN , LI BING , WEI LAN , XU JINYOU , OK HYUN O , LACKNER AARON , KOPKA IHOR E
IPC分类号： A01N57/00 , C07D249/08 , C07D271/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
CPC分类号： C07D413/12 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04
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公开(公告)号：EP2170065A4
公开(公告)日：2011-11-23
申请号：EP08768495
申请日：2008-06-16
申请人： MERCK SHARP & DOHME
发明人： OGAWA ANTHONY , UJJAINWALLA FEROZE , VANDE BUNTE ELLEN K , CHU LIN , ONDEYKA DEBRA , KOPKA IHOR E , LI BING , OK HYUN O , PATEL MINAL , SISCO ROSEMARY
IPC分类号： C07D209/30 , A61K31/506 , A61P9/00 , A61P11/02 , A61P11/06 , C07D213/65 , C07D237/20 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D413/10 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D401/12 , C07D209/30 , C07D213/65 , C07D237/20 , C07D401/10 , C07D403/04 , C07D403/10 , C07D413/10 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
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公开(公告)号：EP2888008A4
公开(公告)日：2016-04-20
申请号：EP13831336
申请日：2013-08-19
申请人： MERCK SHARP & DOHME
发明人： APGAR JAMES M , BIFTU TESFAYE , CHEN PING , FENG DANQING , HICKS JACQUELINE D , KEKEC AHMET , LEAVITT KENNETH J , LI BING , SEBHAT IYASSU , QIAN XIAOXIA , WEI LAN , WILKENING ROBERT R , WU ZHICAI , ARASAPPAN ASHOK
IPC分类号： C07D471/04 , A61K31/415 , A61K31/4184 , A61K31/454 , A61P3/10 , C07D519/00
CPC分类号： C07D471/04 , A61K31/19 , A61K31/366 , A61K31/397 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/5377 , C07C53/18 , C07D519/00 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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公开(公告)号：EP2888007A4
公开(公告)日：2016-04-20
申请号：EP13830944
申请日：2013-08-15
申请人： MERCK SHARP & DOHME
发明人： APGAR JAMES M , BIFTU TESFAYE , CHEN PING , FENG DANQING , HICKS JACQUELINE D , KEKEC AHMET , LEAVITT KENNETH J , LI BING , SEBHAT IYASSU , QIAN XIAOXIA , WEI LAN , WILKENING ROBERT R , WU ZHICAI
IPC分类号： C07D405/12 , A61K31/415 , A61K31/4184 , A61K31/454 , A61P3/10 , C07D417/14
CPC分类号： C07D417/14 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/427 , A61K31/4985 , A61K31/506 , A61K31/5377 , C07D405/12 , C07D405/14 , C07D413/14
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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7.发明公开
公开(公告)号：EP2887807A4
公开(公告)日：2016-04-20
申请号：EP13830916
申请日：2013-08-16
申请人： MERCK SHARP & DOHME
发明人： APGAR JAMES M , ARASAPPAN ASHOK , BIFTU TESFAYE , CHEN PING , FENG DANQING , GUIDRY ERIN , HICKS JACQUELINE D , KEKEC AHMET , LEAVITT KENNETH J , LI BING , SEBHAT IYASSU , QIAN XIAOXIA , WEI LAN , WILKENING ROBERT R , WU ZHICAI
IPC分类号： C07D493/04 , A61K31/4184 , A61P3/10
CPC分类号： C07D493/04 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4196 , A61K31/4245 , A61K31/427 , A61K31/454 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The novel benzimidazole hexahydrofuro[3,2-B]furan derivatives of the present invention are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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公开(公告)号：EP2470021A4
公开(公告)日：2013-01-16
申请号：EP10812498
申请日：2010-08-17
申请人： MERCK SHARP & DOHME
发明人： EDMONDSON SCOTT D , BERGER RICHARD , CHANG LEHUA , COLANDREA VINCENT J , HALE JEFFREY J , HARPER BART , KAR NAM FUNG , LI BING , MORRIELLO GREGORI J , MOYES CHRISTOPHER R , SHA DEYOU , SHEN DONG-MING , WANG LIPING , WENDT HARVEY R , ZHU CHENG
CPC分类号： C07D403/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/048 , C07D491/107 , C07D491/147 , C07D491/20 , C07D495/10 , C07D495/20 , C07D497/10 , C07D498/04 , C07D513/04 , C07D513/20
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公开(公告)号：EP2209761A4
公开(公告)日：2012-01-04
申请号：EP08838226
申请日：2008-10-06
申请人： MERCK SHARP & DOHME
发明人： OGAWA ANTHONY , UJJAINWALLA FEROZE , LI BING , CHU LIN , PATEL MINAL , ARMSTRONG HELEN , OK HYUN OK , SISCO ROSEMARY , MACDONALD DWIGHT , HUTCHINSON JOHN , PERRIER HELENE
IPC分类号： C07D213/30 , A61K31/4439 , A61P9/10 , C07D213/55 , C07D213/56 , C07D237/20 , C07D239/26 , C07D277/24 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02
CPC分类号： C07D401/12 , C07D213/30 , C07D213/55 , C07D213/56 , C07D237/20 , C07D239/26 , C07D277/24 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02
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公开(公告)号：EP1546115A4
公开(公告)日：2010-08-04
申请号：EP03759514
申请日：2003-09-23
申请人： MERCK SHARP & DOHME
发明人： KOPKA IHOR E , LI BING , HAGMANN WILLIAM K
IPC分类号： A61K31/505 , A61K31/513 , A61P25/18 , A61P25/28 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/56 , C07D401/12 , C07D487/08 , A61K31/506 , C07D239/47 , C07D239/48 , C07D239/58
CPC分类号： C07D239/28 , C07D239/34 , C07D239/38 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/54 , C07D239/56 , C07D401/12 , C07D487/08
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