公开(公告)号：EP2278337A3

公开(公告)日：2012-09-26

申请号：EP10174433.2

申请日：2003-05-09

申请人： The University of Chicago

发明人： Ismagilov, Rustem F

IPC分类号： G01N33/577 ,  G01N31/00 ,  G01N35/08 ,  B01F1/00 ,  B01F5/06 ,  B82Y30/00 ,  B01J19/00 ,  B01F13/00

CPC分类号： B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：EP2016189B1

公开(公告)日：2012-01-25

申请号：EP06847588.8

申请日：2006-12-11

申请人： Advanced Liquid Logic, Inc. ,  Duke University ,  The Board of Trustees of the Leland Stanford Junior University

发明人： POLLACK, Michael, G. ,  PAMULA, Vamsee, K. ,  ALLEN, Dwayne, J. ,  FAIR, Richard, B. ,  GRIFFIN, Peter

IPC分类号： C12Q1/68 ,  C07H21/00

CPC分类号： B01L3/502792 ,  B01F11/0071 ,  B01F13/0071 ,  B01F13/0076 ,  B01L3/502715 ,  B01L3/502761 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/089 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0436 ,  B01L2400/0442 ,  B01L2400/0448 ,  C12Q1/6869 ,  G01N33/49 ,  C12Q2565/629 ,  C12Q2565/301

摘要： The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting sequencing protocols, such as the reagents for conducting a pyrosequencing protocol. The invention also includes a droplet microactuator or droplet microactuator system, having one or more input reservoirs loaded with a sample for conducting a pyrosequencing protocol.

公开(公告)号：EP2283918A2

公开(公告)日：2011-02-16

申请号：EP10185097.2

申请日：2003-05-09

申请人： The University of Chicago

发明人： Ismagilov, Rustem F

IPC分类号： B01F5/06 ,  G01N35/08

CPC分类号： B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：EP2283917A2

公开(公告)日：2011-02-16

申请号：EP10183131.1

申请日：2003-05-09

申请人： The University of Chicago

发明人： Ismagilov, Rustem F

IPC分类号： B01F5/06 ,  G01N35/08

CPC分类号： B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：EP1912729B1

公开(公告)日：2010-05-26

申请号：EP06776651.9

申请日：2006-08-07

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： HERMINGHAUS, Stephan ,  SEEMANN, Ralf ,  PRIEST, Craig

IPC分类号： B01F13/00 ,  B01F3/08 ,  B01F5/04 ,  B01F5/06 ,  B01J19/00

CPC分类号： B01F5/0473 ,  B01F3/0807 ,  B01F5/0483 ,  B01F5/0646 ,  B01F5/0653 ,  B01F13/0059 ,  B01F13/0066 ,  B01J19/0093 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0448 ,  B01L2400/0487

摘要： The invention relates to a method for forming an emulsion (1) containing at least one dispersed phase (3) and one continuous phase (2) in a fluid microsystem (100). According to said method, flows (4, 5) are formed from different liquids flowing towards a dispersion region (10), and the emulsion (1) is formed from the liquids in the dispersion region (10). The flows (4, 5) run through a common channel (20) towards the dispersion region (10) and are located (4, 5) adjacently in relation to a first reference direction, and the emulsion (1) is produced during the flow of the liquids over a cross-sectional extension (11) which is provided in the dispersion region (10) and in which the cross-section of the channel (20) is extended in a second reference direction deviating from the first reference direction. The invention also relates to a fluid microsystem for forming an emulsion (1) containing a continuous phase (2) and at least one dispersed phase (3). The invention further relates to a fusion of drops in electrical fields.

公开(公告)号：EP1943499A2

公开(公告)日：2008-07-16

申请号：EP06836471.0

申请日：2006-10-23

申请人： General Electric Company

发明人： SHRIKHANDE, Prashant, V. ,  BOYETTE, Scott, M. ,  XIAO, Caibin ,  POTYRAILO, Radislav, A. ,  LEACH, Andrew, M.

IPC分类号： G01N21/25 ,  B01L3/00

CPC分类号： G01N21/253 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2200/12 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0448 ,  G01N21/78

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample- volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

公开(公告)号：EP1384035A2

公开(公告)日：2004-01-28

申请号：EP02725575.1

申请日：2002-04-09

申请人： RESEARCH TRIANGLE INSTITUTE

发明人： Venkatasubramanian, Rama

IPC分类号： F25B21/02

CPC分类号： B01L7/54 ,  B01L3/5085 ,  B01L7/52 ,  B01L2400/0448 ,  F25B21/04 ,  H01L23/38 ,  H01L27/14649 ,  H01L35/08 ,  H01L2224/95145 ,  H01L2224/95147 ,  H01L2924/01019 ,  H01L2924/01068 ,  H01L2924/01077 ,  H01L2924/1461 ,  H05B3/10 ,  H01L2924/00

摘要： A thermoelectric cooling and heating device (1) including a substrate (1), a plurality of thermoelectric elements (2) arranged on one side of the substrate and configured to perform at least one of selective heating and cooling such that each thermoelectric element (2) includes a thermoelectric material (2b), a Peltier contact (2c) contacting the thermoelectric and forming under electrical current flow at least one of a heated junction and a cooled junction, and electrodes configured to provide current through the thermoelectric material (2b)and the Peltier contact (2c). As such, the thermoelectric cooling and heating device (1) selectively biases the thermoelectric elements (2) to provide on one side of the thermoelectric device (1) a grid of localized heated or cooled junctions.

公开(公告)号：EP3290921A1

公开(公告)日：2018-03-07

申请号：EP17186748.4

申请日：2003-05-09

申请人： The University of Chicago

发明人： ISMAGILOV, Rustem F.

IPC分类号： G01N33/577 ,  G01N31/00 ,  G01N35/08 ,  B01F1/00

CPC分类号： B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

摘要翻译： 本发明提供微制造的基材和在这些基材内进行反应的方法。 这些反应发生在载流流体中运输的塞中。

公开(公告)号：EP2948703A4

公开(公告)日：2016-09-21

申请号：EP14743656

申请日：2014-01-27

申请人： GNUBIO INC

发明人： HUNG TONY ,  ESMAIL ADNAN ,  KIANI SEPEHR

IPC分类号： F16K31/48 ,  B01L3/00

CPC分类号： B01L3/502715 ,  B01L3/502784 ,  B01L2200/06 ,  B01L2200/0605 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/161 ,  B01L2300/1861 ,  B01L2400/0415 ,  B01L2400/0448 ,  B01L2400/0487

摘要： The present invention generally pertains to a system for performing droplet inflation, and methods and kits comprising the same. The system comprises at least one microfluidic channel comprising one or more droplets flowing therein, one or more fluid reservoirs, one or more inflators, one or more inflator nozzles, and at least one mechanism for disrupting an interface between a droplet and a fluid. The present invention provides for the inflation of a relatively controlled volume of fluid into a droplet resulting in an increase in the volume of the droplet relative to its volume prior to inflation and, accordingly, dilution of the concentration of species, if any, previously present and emulsified in the droplet.

摘要翻译： 本发明一般涉及一种用于进行液滴充气的系统，以及包括该系统的方法和试剂盒。 该系统包括至少一个微流体通道，其包括流入其中的一个或多个液滴，一个或多个流体储存器，一个或多个充气器，一个或多个充气器喷嘴，以及用于破坏液滴和流体之间的界面的至少一个机构。 本发明提供将相对受控体积的流体膨胀到液滴中，导致在充气之前相对于其体积的液滴的体积增加，因此稀释先前存在的物质浓度（如果有的话） 并在液滴中乳化。

公开(公告)号：EP2283918A3

公开(公告)日：2012-08-01

申请号：EP10185097.2

申请日：2003-05-09

申请人： The University of Chicago

发明人： Ismagilov, Rustem F

IPC分类号： G01N33/577 ,  G01N31/00 ,  G01N35/08 ,  B01F1/00 ,  B01F5/06 ,  B82Y30/00 ,  B01J19/00 ,  B01F13/00

CPC分类号： B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.