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公开(公告)号：EP3116316B1
公开(公告)日：2019-07-10
申请号：EP15761201.1
申请日：2015-03-13
IPC分类号： A01N43/00 , A61K31/55 , C07D498/00
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公开(公告)号：EP2531032B1
公开(公告)日：2019-04-10
申请号：EP11740474.9
申请日：2011-02-05
发明人： TURCHI, John, J. , SHUCK, Sarah
IPC分类号： A61K31/415 , A61K31/4709 , A61K31/5377 , A61K33/24 , A61P35/00 , C07D401/04
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公开(公告)号：EP3349761A1
公开(公告)日：2018-07-25
申请号：EP16847298.3
申请日：2016-09-15
发明人： TURNER, William , ARNOLD, Lee, Daniel , MAAG, Hans , BURES, Mark
IPC分类号： A61K31/554 , C07D281/16 , C07D417/12
CPC分类号： C07D417/12 , A61K45/06 , A61P31/20 , C07D243/38 , C07D267/20 , C07D281/16 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/14 , C07D453/02 , C07D471/04
摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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94.发明授权
公开(公告)号：EP2780031B1
公开(公告)日：2018-03-07
申请号：EP12849285.7
申请日：2012-11-16
发明人： DIMARCHI, Richard D. , YANG, Bin
CPC分类号： C07K14/605 , A61K38/00 , A61K47/554 , C07K2319/715
摘要： Provided herein are glucagon superfamily peptides conjugated with GR ligands that are capable of acting at a glucocorticoid receptor. Also provided herein are pharmaceutical compositions and kits of the conjugates of the invention. Further provided herein are methods of treating a disease, e.g., a metabolic disorder, such as diabetes and obesity, comprising administering the conjugates of the invention.
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95.发明授权USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS 有权TRPV4拮抗剂在AMELIORATE HYDROFSALUS中的应用及相关材料和方法
公开(公告)号：EP2925857B1
公开(公告)日：2018-02-14
申请号：EP13859760.4
申请日：2013-12-03
IPC分类号： A61K31/4439 , C12N5/00 , C12N5/02 , A61K38/00 , A61K47/00 , A61K31/165 , A61P25/00 , A61K31/00 , A61K31/405 , A61K31/55 , A61K31/5377 , A61K31/4995 , A61K31/496 , A61K31/495 , A61K31/28 , A61K31/225 , A61K31/202 , A61K31/18
CPC分类号： A61K31/5377 , A61K31/00 , A61K31/165 , A61K31/18 , A61K31/202 , A61K31/225 , A61K31/28 , A61K31/405 , A61K31/4439 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K31/55 , A61M27/006
摘要： The present invention provides uses of TRPV4 antagonists in the treatment or prevention of hydrocephalus symptoms, also known as hydrocephaly, including hydrocephalus as a result of any structural defect, any metabolic defect, any injury (direct force to the head, indirect force to the head, shock waves, pressure changes, etc.), any insult (microbial, chemical, toxins, allergic reactions or other inflammatory process, or other pathology, eg. cancer, benign tumor, etc.). Related materials and methods are also provided herein.
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96.发明授权RECHARGEABLE ALKALINE METAL AND ALKALINE EARTH ELECTRODES HAVING CONTROLLED DENDRITIC GROWTH AND METHODS FOR MAKING AND USING THE SAME 有权可控碱性金属和具有可控树枝状生长的碱性土电极及其制备和使用方法
公开(公告)号：EP2710653B1
公开(公告)日：2017-11-29
申请号：EP12786692.9
申请日：2012-05-17
发明人： XIE, Jian
IPC分类号： H01M4/1395 , H01M10/0566
CPC分类号： H01M4/1395 , B82Y30/00 , H01M2/164 , H01M2/1686 , H01M10/052 , H01M10/0566 , Y02E60/122
摘要： A method of extending the life of a battery, including positioning a dendrite seeding material in an electrolyte solution disposed between a metal-containing electrode and an electrolyte permeable separator membrane, growing metal dendrites from the lithium dendrite seeding material toward the lithium-containing electrode, and contacting metal dendrites extending from the metal containing electrode with metal dendrites extending from the metal dendrite seeding material, wherein the electrolyte contains metal ions.
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97.发明公开METHODS AND COMPOSITIONS FOR TREATING HEPATITIS B VIRUS INFECTIONS 审中-公开VERFAHREN UND ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON HEPATITIS-B-VIRENINFEKTIONEN
公开(公告)号：EP3139954A1
公开(公告)日：2017-03-15
申请号：EP15788791.0
申请日：2015-05-11
IPC分类号： A61K39/29 , A61K45/06 , G01N33/576
CPC分类号： A61K31/5377 , A61K31/18 , A61K31/445 , A61K31/506 , A61K31/713 , A61K45/06 , G01N33/5023 , G01N33/5032 , G01N33/5762 , G01N2500/04
摘要： Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful for the same.
摘要翻译： 本文描述了用于鉴定可用于治疗乙型肝炎病毒（HBV）感染的化合物和鉴定对其有用的化合物的方法。
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公开(公告)号：EP2676673B1
公开(公告)日：2016-11-16
申请号：EP13174153.0
申请日：2009-06-16
发明人： Dimarchi, Richard D. , Smiley, David L. , Dimarchi, Maria , Chabenne, Joseph , Day, Jonathan , Patterson, James , Ward, Brian, C.
IPC分类号： A61K38/00 , C07K14/605
CPC分类号： C07K14/605
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99.发明公开AMIDE BASED GLUCAGON SUPERFAMILY PEPTIDE PRODRUGS 审中-公开AMIDBASIERTE PEPTID-PRODRUGS DER GLUCAGON-SUPERFAMILIE
公开(公告)号：EP3075385A1
公开(公告)日：2016-10-05
申请号：EP16164599.9
申请日：2009-12-18
发明人： DIMARCHI, Richard, D. , KOU, Binbin
CPC分类号： A61K38/26 , A61K2300/00
摘要： Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
摘要翻译： 提供胰高血糖素超家族肽的前药制剂，其中胰高血糖素超家族肽已经通过二肽与胰高血糖素超家族通过酰胺键键连接而被修饰。 本文公开的前体药物具有延长的半衰期并且通过由化学不稳定性驱动的非酶反应在生理条件下转化为活性形式。
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100.发明授权SINGLE CHAIN INSULIN AGONISTS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR 有权具有高活性对胰岛素受体的单链胰岛素激动剂
公开(公告)号：EP2582719B1
公开(公告)日：2016-08-10
申请号：EP11796430.4
申请日：2011-06-16
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