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266 条记录 (耗时 0.057 秒)

    BLOCK DECOYS
    92.
    发明公开
    BLOCK DECOYS 审中-公开
    BLOCKKÖDER

    公开(公告)号：EP3011027A1

    公开(公告)日：2016-04-27

    申请号：EP14731259.9

    申请日：2014-06-17

    申请人： UCB Biopharma SPRL

    发明人： JAMES, David Cameron ,  BROWN, Adam John

    IPC分类号： C12N15/113

    CPC分类号： C12N15/113 ,  C12N2310/13 ,  C12N2310/51 ,  C12N2310/532 ,  C12N2320/51 ,  C12P21/00

    摘要： The present disclosure relates to a method of preparing exonuclease resistant molecules of block- decoys, use of the molecules in methods of modulating expression of recombinant proteins, particularly in vitro, for example by down regulation or inhibition of one or more transcription factors, and novel molecules of block-decoys, especially those obtained or obtainable from the methods herein. The disclosure also relates to use of said block decoys in vitro and in therapy. In one aspect there is provided a method for regulating recombinant gene expression in vitro comprising the steps of: a) providing a host cell encoding one or more recombinant genes for expression, b) contacting the cell with a exonuclease resistant block-decoy under condition suitable for the block-decoy to gain entry into the cell, and c) expressing the recombinant protein or protein.

    摘要翻译： 本公开内容涉及制备嵌段诱饵的外切核酸酶抗性分子的方法，所述分子在调节重组蛋白表达的方法中的用途，特别是在体外，例如通过下调或抑制一种或多种转录因子，以及新颖的 特别是从本文的方法获得或可获得的那些块诱饵的分子。 本公开还涉及在体外和治疗中使用所述块诱饵。 在一个方面，提供了一种用于在体外调节重组基因表达的方法，其包括以下步骤：a）提供编码一种或多种用于表达的重组基因的宿主细胞，b）在合适的条件下使细胞与外切核酸酶抗性阻滞诱饵接触 用于阻止诱饵进入细胞，和c）表达重组蛋白或蛋白质。

    AUTO-INJECTOR
    96.
    发明公开
    AUTO-INJECTOR 有权
    自动注射器

    公开(公告)号：EP2879737A1

    公开(公告)日：2015-06-10

    申请号：EP13741801.8

    申请日：2013-07-29

    申请人： UCB Biopharma SPRL

    发明人： McLOUGHLIN, Martin John ,  HEALD, Michael James David ,  MELZI, Ilario ,  VERLAAK, Stefan ,  PALOMBI, Tatiana

    IPC分类号： A61M5/20 ,  A61M5/315

    CPC分类号： A61M5/1456 ,  A61M5/002 ,  A61M5/158 ,  A61M5/20 ,  A61M5/3134 ,  A61M5/31505 ,  A61M5/31515 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/326 ,  A61M2005/2013 ,  A61M2005/206 ,  A61M2005/2477 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/583 ,  A61M2205/586 ,  A61M2205/8206

    摘要： Provided is a cassette unit suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity and a needle projection aperture. The housing cavity may receive a syringe. Axially movable within the barrel of the syringe for forward movement into contact with the syringe plunger, there is a plunger slaving part defining a circumferential wall arranged for frictional sliding relationship with the inner wall of the barrel, a rear drive-receiving face and a front plunger-contacting face. The plunger slaving part is arranged such that when a drive load is applied to its rear drive-receiving face to bring the front plunger-contacting face into contact with the plunger the drive load is evenly transmitted. The circumferential wall is provided with slide restrictors that restrict frictional sliding movement thereof in relation to the inner wall of the barrel.

    摘要翻译： 提供了一种适用于具有电驱动单元的自动注射器的盒式单元。 盒单元包括限定盒单元容纳腔和盒突出孔的盒单元壳体。 壳体腔可以容纳注射器。 在注射器筒体内轴向移动以向前移动而与注射器柱塞接触，存在柱塞从动部件，其限定了与筒体的内壁摩擦滑动关系设置的周向壁，后部驱动器接收面和前部 柱塞接触面。 柱塞从动部件设置成当驱动负载施加到其后驱动接收面上以使前柱塞接触面与柱塞接触时，驱动负载均匀地传递。 周壁设有滑动限制器，该滑动限制器限制其相对于筒的内壁的摩擦滑动。