公开(公告)号：EP0607346A1

公开(公告)日：1994-07-27

申请号：EP92922523.0

申请日：1992-10-07

申请人： ORGANOGENESIS INC.

发明人： KEMP, Paul, D. ,  CARR, Robert, M., Jr. ,  MARESH, John G. ,  CAVALLARO, John ,  GROSS, Jerome

IPC分类号： A61F2 ,  A61K38 ,  A61L27 ,  A61P43 ,  D01F4

CPC分类号： A61L27/507 ,  A61F2/06 ,  A61F2/08 ,  A61F2310/00365 ,  A61L27/24 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/60 ,  D01F4/00 ,  Y10S623/901

摘要： The present invention provides improved collagen threads and methods of making and using such threads, including the production of yarn, as well as braided, knitted, and woven articles of manufacture, comprising such threads.

公开(公告)号：EP0418035A1

公开(公告)日：1991-03-20

申请号：EP90309942.2

申请日：1990-09-11

申请人： ORGANOGENESIS INC.

发明人： Kemp, Paul ,  Bell, Eugene ,  Kagan, David T. ,  Mason, Valerie ,  Cavallaro, John

IPC分类号： C12N5/00 ,  A61L27/00 ,  C12M3/00

CPC分类号： C12N5/0698 ,  A61L27/60 ,  C12M25/04 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2533/54

摘要： The present invention provides improved tissue equivalents and methods of making and using such tissue equivalents. The present invention also provides test apparatus incorporating such improved tissue equivalents.

摘要翻译： 本发明提供了改进的组织等同物和制备和使用这种组织等同物的方法。 本发明还提供了包含这种改进的组织等同物的测试装置。

公开(公告)号：EP0344924A2

公开(公告)日：1989-12-06

申请号：EP89304555.9

申请日：1989-05-05

申请人： ORGANOGENESIS INC.

发明人： Weinberg, Crispin B.

IPC分类号： A61L27/00 ,  A61L15/04

CPC分类号： A61L27/38 ,  A61F2310/00365 ,  A61F2310/00377 ,  A61L27/225 ,  A61L27/24 ,  A61L27/36 ,  A61L27/507 ,  A61L27/54 ,  A61L27/60 ,  C07K17/02 ,  C07K17/06 ,  C12N5/0068 ,  C12N5/0691 ,  C12N2533/54 ,  C12N2533/56

摘要： The present invention provides fibrin-collagen tissue equivalents and methods of making and using such tissue equivalents. The present invention also provides methods of forming multi-layer tissue equivalents having improved adherence of the layers. The present invention further provides a method for joining tears in tissue equivalents.

摘要翻译： 本发明提供纤维蛋白 - 胶原组织等同物和制备和使用这种组织等同物的方法。 本发明还提供形成具有改善的层附着力的多层组织等同物的方法。 本发明还提供了一种用于在组织等价物中接合眼泪的方法。

公开(公告)号：EP4373535A2

公开(公告)日：2024-05-29

申请号：EP22846820.3

申请日：2022-07-20

申请人： ORGANOGENESIS INC.

发明人： BILBO, Patrick ,  FARIA, Katherine ,  MOWRY, Bonnie Kathleen ,  RAUT, Vivek

IPC分类号： A61L26/00 ,  A61L15/32 ,  A61L17/08

CPC分类号： A61L26/0033 ,  A61L26/0066 ,  A61L26/0085 ,  A61L2300/40420130101 ,  A61L2300/20620130101 ,  A61K45/06 ,  A61K31/785 ,  A61K31/14 ,  A61K31/155

公开(公告)号：EP1551948B1

公开(公告)日：2018-01-31

申请号：EP03763030.8

申请日：2003-06-26

申请人： ORGANOGENESIS INC.

发明人： ROOS, Eric ,  O'REILLY, Christopher ,  CHEVERE, Ruben ,  WILKINS, Leon, M.

IPC分类号： C12M1/12 ,  C12M1/22 ,  C12M3/06 ,  C12M3/04 ,  C12M1/26

CPC分类号： C12M23/24 ,  C12M23/12 ,  C12M23/38

摘要： A bioreactor has a base for defining a well, a dish with a membrane suspended in the base, and a lid with gas permeable membranes and self-sealing ports.

公开(公告)号：EP2524034A1

公开(公告)日：2012-11-21

申请号：EP11701589.1

申请日：2011-01-14

申请人： Organogenesis, Inc.

发明人： RONFARD, Vincent ,  BAKSH, Dolores ,  WANG, Xianyan ,  WONG, Matthew, Quin-men ,  CAO, Lan ,  SAVA, Parid ,  BOLLENBACH, Thomas ,  YESILALAN, Esin

IPC分类号： C12N5/0775 ,  A61L27/36

CPC分类号： C12N5/0663 ,  A61K2035/124 ,  A61L27/3633 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/3886 ,  A61L27/3891 ,  C12N5/0667 ,  C12N5/0668 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/90 ,  C12N2501/02 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/148 ,  C12N2501/39 ,  C12N2533/90

摘要： Bioengineered constructs are formed from cultured cells induced to synthesize and secrete endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. The bioengineered constructs of the invention can be produced with multiple cell types that can all contribute to producing the extracellular matrix. Additionally or alternatively, one of the multiple cell types can be delivered to a site in the body via the endogenously produced extracellular matrix components to achieve various therapeutic benefits.

公开(公告)号：EP1461440B1

公开(公告)日：2011-11-09

申请号：EP02786886.8

申请日：2002-12-04

申请人： ORGANOGENESIS INC.

发明人： JIN, Jianjian

IPC分类号： C12N5/071 ,  C12N5/074

CPC分类号： C12N5/0678 ,  A61K35/12 ,  C12N2500/25 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/40 ,  C12N2501/11 ,  C12N2501/39 ,  C12N2501/395 ,  C12N2506/22

摘要： A cell composition of endocrine progenitor cells derived from mammalian pancreatic islet cells that can be trans-planted planted into a diabetic patient such t the cells of the cell composition differentiates into functioning insulin-producing beta cells.

公开(公告)号：EP1998787A4

公开(公告)日：2010-04-21

申请号：EP07757907

申请日：2007-03-05

申请人： ORGANOGENESIS INC

发明人： EKLUND DARIO C

IPC分类号： A01N63/00 ,  C12N11/00

CPC分类号： A61L27/3641 ,  A61K35/12 ,  A61K35/33 ,  A61L27/3633 ,  A61L27/3804 ,  A61L27/3813 ,  A61L27/3839 ,  A61L27/3891 ,  C12N5/0656 ,  C12N5/0698 ,  C12N2500/25 ,  C12N2500/32 ,  C12N2500/36 ,  C12N2500/38 ,  C12N2500/40 ,  C12N2500/50 ,  C12N2500/90 ,  C12N2501/11 ,  C12N2501/39 ,  C12N2501/392 ,  C12N2501/395 ,  C12N2502/094 ,  C12N2502/1323

摘要： A method for treating an oral condition of a subject by grafting cultured tissue constructs to the oral tissue. The cultured tissue constructs comprise cultured cells and endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. Some tissue constructs of the invention are comprised of multiple cell layers or more than one cell type. The tissue constructs of the invention have morphological features and functions similar to tissues their cells are derived and their strength makes them easily handleable. Preferred cultured tissue constructs of the invention comprise cells derived from human tissue.

公开(公告)号：EP2068766A4

公开(公告)日：2010-03-31

申请号：EP07813589

申请日：2007-07-31

申请人： ORGANOGENESIS INC

发明人： HAMMOND DENNIS C ,  CODORI-HURFF JEANNE M

IPC分类号： A61F2/12 ,  A61K35/38

CPC分类号： A61F2/12 ,  A61F2210/0004

摘要： Mastopexy and breast reconstruction prostheses and implantation method that allow for radiographic imaging of the breast tissue. The prostheses are arcuate and elongate optionally meshed to conform with breast tissue when implanted. Prostheses are made from naturally occurring extracellular matrix, primarily collagen, that, allows for mammographic imaging without interference as is expected from synthetic materials.

公开(公告)号：EP1083828B1

公开(公告)日：2009-03-04

申请号：EP99928418.5

申请日：1999-06-04

申请人： ORGANOGENESIS INC.

发明人： ABRAHAM, Ginger, A. ,  SULLIVAN, Susan, J. ,  MURRAY, James

IPC分类号： A61B17/00 ,  A61F2/00 ,  A61F2/06 ,  A61L27/00

CPC分类号： A61L27/3629 ,  A61F2/06 ,  A61L27/24 ,  A61L27/3641 ,  A61L27/3687 ,  A61L27/40 ,  A61L27/507 ,  B29C53/40 ,  B29C53/562

摘要： The invention is directed to bioengineered graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or use in a mammalian host.