公开(公告)号：EP2265948A2

公开(公告)日：2010-12-29

申请号：EP09717826.3

申请日：2009-02-26

申请人： Biomedomics, Inc.

发明人： WANG, Xue-Feng

IPC分类号： G01N33/53

CPC分类号： G01N33/86 ,  G01N2333/522 ,  G01N2400/40 ,  G01N2800/222 ,  Y10S435/97

摘要： Disclosed herein is a lateral flow immuno-assay system capable of rapidly, cost effectively, and quantitatively detecting and assessing the level of HIT antibodies in body fluids of a patient. Also taught are methods for employing the system to assist in diagnosis of HIT, and for screening or detecting a changing titer of HIT antibodies in the body fluids of a patient to determine susceptibility toward HIT.

公开(公告)号：EP1092978B1

公开(公告)日：2010-09-08

申请号：EP00122072.2

申请日：2000-10-11

申请人： Sorin Group Italia S.r.l.

发明人： Caputo, Giuseppe ,  Castelli, Raffaele ,  Comoglio, Elena ,  Della Ciana, Leopoldo ,  Giannetti, Arnaldo

IPC分类号： G01N33/52

CPC分类号： G01N33/5308 ,  G01N2400/40

公开(公告)号：EP1532438B1

公开(公告)日：2010-05-12

申请号：EP03727020.4

申请日：2003-06-13

申请人： WOMEN'S AND CHILDREN'S HOSPITAL

发明人： MEIKLE, Peter, John ,  FULLER, Maria ,  RAMSEY, Steve, Lewis ,  RANIERI, Enzo ,  HOPWOOD, John, Joseph

IPC分类号： G01N33/48

CPC分类号： G01N33/66 ,  G01N2400/40

公开(公告)号：EP2032716A4

公开(公告)日：2010-03-17

申请号：EP07794829

申请日：2007-05-14

申请人： UNIV MIAMI

发明人： FRANZMANN ELIZABETH J ,  LOKESHWAR VINATA B

IPC分类号： C12Q1/00 ,  G01N33/574

CPC分类号： G01N33/57407 ,  G01N33/573 ,  G01N33/57488 ,  G01N2333/70585 ,  G01N2333/924 ,  G01N2333/926 ,  G01N2400/40 ,  G01N2800/52

摘要： Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described.

公开(公告)号：EP2089709A1

公开(公告)日：2009-08-19

申请号：EP07815162.8

申请日：2007-10-30

申请人： Protaffin Biotechnologie AG

发明人： KUNGL, Andreas

IPC分类号： G01N33/50 ,  G01N33/569

CPC分类号： G01N33/5029 ,  G01N2333/475 ,  G01N2333/52 ,  G01N2400/40

摘要： The present invention relates to a system for measuring the biological activity of chemoattractants comprising at least two units separated by a semipermeable carrier wherein biologically active carbohydrate structures, preferably glycosaminoglycan (GAG) structures, are immobilized on the surface of said carrier. According to the invention, this system can be used for fast and economic measurement of the degree of cell mobility and chemotactic activity.

公开(公告)号：EP1870421A4

公开(公告)日：2008-12-24

申请号：EP06730856

申请日：2006-03-31

申请人： SEIKAGAKU KOGYO CO LTD

发明人： SUZUKI KIYOSHI ,  ISHIMARU TAKESHI ,  YAMAMOTO KOJI

IPC分类号： C07K16/18 ,  C07K14/47 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  G01N33/53

CPC分类号： C07K16/44 ,  G01N33/5308 ,  G01N2400/40 ,  Y10S435/975

摘要： An antibody which can react with N-acetylheparosan and heparan sulfate derived from bovine kidney but cannot substantially react with heparan sulfate derived from a murine Engelbreath-Holm-Swarn tumor tissue, the antibody being produced with a hybridoma which is prepared using a substance composed of a protein and N-acetylheparosan bound to the protein.

公开(公告)号：EP1752767A4

公开(公告)日：2008-10-15

申请号：EP05739187

申请日：2005-05-10

申请人： WAKO PURE CHEM IND LTD

发明人： SUMIDA KYOICHI ,  FUJIO KAZUNARI ,  KOBATAKE SHINZO

IPC分类号： G01N33/53 ,  G01N21/82 ,  G01N33/543 ,  G01N33/545

CPC分类号： G01N33/543 ,  G01N21/82 ,  G01N2400/40

摘要： It is intended to provide a method of assaying hyaluronic acid by using a support which suffers from little sedimentation of the support, is excellent in storage stability and shows such a high accuracy as being comparable with the existing reagents; and a reagent kit. Namely, a method of assaying hyaluronic acid characterized by comprising contacting hyaluronic acid in a sample with HABP to form a hyaluronic acid/HABP complex, then reacting the complex with a support carrying an anti-HABP antibody, measuring an optical change caused by an aggregate formed by the above reaction and calculating the amount of hyaluronic acid based on the measurement data; and a reagent kit for assaying hyaluronic acid which comprises a reagent containing HABP and a support carrying an anti-HABO antibody.

公开(公告)号：EP1870421A1

公开(公告)日：2007-12-26

申请号：EP06730856.9

申请日：2006-03-31

申请人： SEIKAGAKU CORPORATION

发明人： SUZUKI, Kiyoshi c/o SEIKAGAKU CORPORATION Central ,  ISHIMARU, Takeshi, SEIKAGAKU CORPORATION Central ,  YAMAMOTO, Koji c/o SEIKAGAKU CORPORATION Central

IPC分类号： C07K16/18 ,  C12P21/08 ,  C12N15/02 ,  C07K14/47 ,  C12N5/10 ,  G01N33/53

CPC分类号： C07K16/44 ,  G01N33/5308 ,  G01N2400/40 ,  Y10S435/975

摘要： An antibody which reacts with N-acetylheparosan and heparan sulfate that is derived from bovine kidney but does not substantially react with heparan sulfate derived from a murine Engelbreath-Holm-Swarn tumor tissue, the antibody being produced with a hybridoma which is prepared using a substance composed of a protein and N-acetylheparosan bound to the protein.

摘要翻译： 与源自牛肾但不与源自鼠Engelbreath-Holm-Swarn肿瘤组织的硫酸乙酰肝素基本上反应的N-乙酰肝素和硫酸乙酰肝素反应的抗体，所述抗体由使用物质制备的杂交瘤产生 由与蛋白质结合的蛋白质和N-乙酰西他班组成。

公开(公告)号：EP1810031A2

公开(公告)日：2007-07-25

申请号：EP05810321.9

申请日：2005-10-04

申请人： Akers Biosciences, Inc.

发明人： MILUNIC, David ,  ANDRELCZYK, Susan

IPC分类号： G01N33/543

CPC分类号： G01N33/6863 ,  B01L3/5023 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2400/0683 ,  G01N33/54313 ,  G01N33/564 ,  G01N33/6893 ,  G01N33/86 ,  G01N2333/522 ,  G01N2400/40 ,  G01N2800/222

摘要： Methods for determining the presence of heparin/platelet factor 4 antibodies in a sample suspected to contain heparin/platelet factor 4 antibodies are provided, along with apparatus suitable for performing the methods. The method depends upon a color visualization indicating the presence or absence of heparin/platelet factor 4 antibodies in the sample. Preferred methods comprise contacting the sample with particles being complexed to platelet factor 4 (PF4) and which particle-complexed PF4 reacts specifically with heparin/platelet factor 4 antibodies, passing the sample/particle mixture through a filter, and then analyzing the color of the filtrate. The presence of heparin/platelet factor 4 antibodies in the sample is established where the color of the filtrate is substantially different from the color of the receptor-bearing particles.

公开(公告)号：EP1752772A1

公开(公告)日：2007-02-14

申请号：EP06014877.2

申请日：2006-07-18

申请人： Dade Behring Marburg GmbH

发明人： Klein, Wolfgang, Dr. ,  Zander, Norbert, Dr.

IPC分类号： G01N33/86

CPC分类号： C12Q1/56 ,  G01N33/54393 ,  G01N2333/96444 ,  G01N2400/40

摘要： Die vorliegende Erfindung liegt auf dem Gebiet der Gerinnungsdiagnostik und betrifft ein Verfahren zur Bestimmung der Heparinaktivität in einer Probe, wobei die Probe zunächst mit einer Heparin-modifizierenden Komponente wie zum Beispiel Heparinase, inkubiert wird und anschließend die Heparin-abhängige FXa-Inaktivierung gemessen wird.

摘要翻译： 肝素依赖失活的混合因子Xa被量化。 在添加因子Xa之前，将样品与肝素修饰组分一起温育。 样品可以与来自肝素酶的酶或来自葡糖醛酸糖苷酶的酶或来自这些组中的一个或两个的不同酶的混合物一起温育。 包含用于执行该方法的测试工具的独立权利要求。