摘要:
The present invention relates to a phenothiazinium compound of Formula (I), wherein A and B are each independently (a) or (b) in which Z is CH2, O, S, SO2, NH, NCH3, NC2H5, NCH2CH2OH, or NCOCH3 and R?1 and R2¿ are each independently linear or branched C¿n?H2nY, where n is 1-6, Y is H, F, Cl, Br, I, OH, OCH3, OC2H5, OC3H7, CN or OCOCH3, and where X?P-¿ is a counteranion and P is 1, 2 or 3 but not including a compound where A and B are both either-N(CH¿3?)2 or -N(CH2CH3)2. The invention also relates to use of the compound of the invention as a PDT agent or a photodiagnostic agent.
摘要:
A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid ß peptides (Aß) and/or with a changed ratio of levels of A isoforms and/or with the formation of plaques containing amyloid ß peptide (Aß) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas (Ia), (Ib) wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
摘要:
Processes are disclosed for the synthesis of Delta-9 tetrahydrocannabinol which result in an improved Y-THC/Y-THC ratio, and intermediates are disclosed that may be used in the synthesis of Delta-9 tetrahydrocannabinol such that improved Y-THCIY-THC ratios are achieved. The intermediates may be cyclic compounds prepared from 2-Carene. There is also provided a scaleable process for the preparation of (+)-p-menth-2-ene-1, 8-diol,, another intermediate used in the synthesis of delta-9-tetrahydrocannibinol.
摘要:
Benzothiazine compounds of the general formula (I) and pharmaceutically acceptable salts or esters thereof are peptide deformylase inhibitors useful in the treatment or prevention of infections and other diseases in which peptide deformylases are involved, especially in the treatment of bacterial and parasitic infections, for example infections fully or partly caused by microorganisms belonging to Staphylococcus, Enterococcus, Streptococcus, Haemophilus, Moraxella, Escherichia, Mycobacterium, Mycoplasma, Pseudomonas, Chlamydia, Rickettsia, Klebsiella, Shigella, Salmonella, Bordetella, Clostridium, Helicobacter, Campylobacter, Legionella or Neisseria.
wherein each of R 2 and R 3 is, same or different, C2-C4 alkyl or the like; or R 2 and R 3 are taken together with the adjacent carbon atom to form a 5 to 8 membered non-aromatic carbocyclic ring; R 4 is C1-C6 alkyl or the like; X is an oxgen atom or a sulfur atom; A is the group of the formula:
wherein R 1 is, same or different, alkyl or the like; W is C2-C6 alkylene which may contain an optionally substituted heteroatom(s) or the like; n is an integer of 0 to 7, a pharmaceutically acceptable salt, or a solvate thereof.
摘要:
Compounds of formula (I) inhibit the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
摘要:
The present invention provides organophotoreceptors comprising an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising:
(a) a charge transport material having the formula where Z 1 and Z 2 comprise, each independently, a bond, a vinyl group, a - CR 1 =N-NR 2 - group, or a -CR 3 =N-N=CR 4 - group; Y 1 and Y 2 comprise, each independently, an aromatic group; X 1 and X 2 are, each independently, a linking group; W 1 and W 2 are, each independently, a -(CH 2 ) n - group or a -(CH 2 ) n-1 -C(=O)-group, where n is an integer between 1 and 10, inclusive; Q 1 and Q 2 are, each independently, O, S, or NR; and R 1 , R 2 , R 3 , R 4 , R, R', and R" comprise, each independently, H, an alkyl group, an alkenyl group, an alkynyl group, an acyl group, a heterocyclic group, or an aromatic group; and (b) a charge generating compound.
Corresponding electrophotographic apparatuses and imaging methods are described, as are charge transport materials and methods of preparing a bridged charge transport material.