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101.发明公开COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES 审中-公开成分与链接多拉司他汀衍生物非天然氨基酸和方法含有这些物质及其用途
公开(公告)号：EP2714684A4
公开(公告)日：2015-04-08
申请号：EP12793246
申请日：2012-05-24
申请人： AMBRX INC
发明人： MIAO ZHENWEI , ATKINSON KYLE C , BIROC SANDRA , BUSS TIMOTHY , COOK MELISSA , KRAYNOV VADIM , MARSDEN ROBIN , PINKSTAFF JASON , SKIDMORE LILLIAN , SUN YING , SZYDLIK ANGIESZKA , LOPEZ DE VALENTA IANINA
IPC分类号： C07D417/12 , A61K31/427 , A61P35/00 , C07D207/08 , C07D401/12 , C07K5/02 , C07K16/30
CPC分类号： C07K5/101 , A61K38/07 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6855 , A61K47/6861 , C07D207/08 , C07D401/12 , C07D417/12 , C07K5/0205 , C07K5/06043
摘要： Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.
摘要翻译： 公开在可用于制备寻求非天然氨基酸和多肽的非天然氨基酸和多拉司他汀类似物也包括至少一个非天然氨基酸，和方法。 多拉司他汀类似物可包括宽范围的可能的功能性的，但典型地具有至少一个肟，羰基，二羰基，和/或羟胺基团。 因此游离缺失盘是在非天然氨基酸多拉司类似物没有被翻译后修饰此外，方法用于实现寻求修改，并寻求多拉司他汀类似物的净化方法。 典型地，修饰的多拉司他汀类似物包括至少一个肟，羰基，二羰基，和/或羟胺基团。 进一步游离缺失光盘是使用搜索非天然氨基酸多拉司他汀类似物和多拉司他汀的经修饰非天然氨基酸类似物，包括治疗，诊断和其它生物技术使用的方法。
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102.发明公开COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES 有权成分与链接多拉司他汀衍生物非天然氨基酸和方法含有这些物质及其用途
公开(公告)号：EP2714685A4
公开(公告)日：2015-01-21
申请号：EP12793459
申请日：2012-05-24
申请人： AMBRX INC
发明人： MIAO ZHENWEI , ATKINSON KYLE C , BIROC SANDRA , BUSS TIMOTHY , COOK MELISSA , KRAYNOV VADIM , MARSDEN ROBIN , PINKSTAFF JASON , SKIDMORE LILLIAN , SUN YING , SZYDLIK AGNIESZKA , LOPEZ DE VALENTA DELIA IANINA
IPC分类号： C07D417/12 , A61K31/427 , A61P35/00 , C07D207/325 , C07D401/12 , C07K5/02
CPC分类号： C07K5/06 , A61K31/337 , A61K31/427 , A61K39/39558 , A61K47/6803 , A61K47/6855 , A61K2039/505 , C07D207/325 , C07D401/12 , C07D417/12 , C07K5/02 , C07K16/2896 , C07K2317/24 , C07K2317/76 , A61K2300/00
摘要： Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.
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公开(公告)号：EP2820034A1
公开(公告)日：2015-01-07
申请号：EP13755219.6
申请日：2013-02-27
申请人： Ambrx, Inc.
IPC分类号： C07K14/00
CPC分类号： C07K14/575 , A61K38/00 , C07K14/5759
摘要： Modified adiopnectin polypeptides and uses thereof are provided.
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104.发明公开COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES 审中-公开成分与链接多拉司他汀衍生物非天然氨基酸和方法含有这些物质及其用途
公开(公告)号：EP2714684A1
公开(公告)日：2014-04-09
申请号：EP12793246.5
申请日：2012-05-24
申请人： Ambrx, Inc.
发明人： MIAO, Zhenwei , ATKINSON, Kyle, C. , BIROC, Sandra , BUSS, Timothy , COOK, Melissa , KRAYNOV, Vadim , MARSDEN, Robin , PINKSTAFF, Jason , SKIDMORE, Lillian , SUN, Ying , SZYDLIK, Angieszka , LOPEZ DE VALENTA, Ianina
IPC分类号： C07D417/12 , C07D207/08 , C07D401/12 , A61K31/427 , A61P35/00
CPC分类号： C07K5/101 , A61K38/07 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6855 , A61K47/6861 , C07D207/08 , C07D401/12 , C07D417/12 , C07K5/0205 , C07K5/06043
摘要： Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.
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106.发明公开Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 审中-公开组合物及其使用的方法和非天然氨基酸和多肽使用
公开(公告)号：EP2399893A3
公开(公告)日：2012-08-08
申请号：EP11177567.2
申请日：2005-12-21
申请人： Ambrx, Inc.
发明人： Miao, Zhenwei , Liu, Junjie , Norman, Thea , Driver, Russell
IPC分类号： C07C22/00 , C07C227/00 , C07C2/00 , A61K38/00 , C07C251/28 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07C229/36 , C07C237/32 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07D209/38
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oximine, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译： 公开在可用于制备寻求非天然氨基酸和多肽的非天然氨基酸和多肽也包括至少一个非天然氨基酸，和方法。 非天然氨基酸，自身或作为多肽的部分，可以包括宽范围的可能功能性的，但典型的具有至少一个肟，羰基，二羰基，和/或羟胺基团。 因此游离缺失盘的都是非天然氨基酸多肽没有被翻译后修饰的。此外，用于实现寻求修改提纯搜索多肽的方法，和方法。 典型地，经修饰非天然氨基酸多肽包含至少一个氧肟，羰基，二羰基，和/或羟胺基团。 进一步游离缺失光盘是使用搜索非天然氨基酸多肽和经修饰非天然氨基酸多肽，包括治疗，诊断和其它生物技术使用的方法。
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公开(公告)号：EP1893229B1
公开(公告)日：2011-10-19
申请号：EP06772153.0
申请日：2006-06-02
申请人： Ambrx, Inc.
发明人： HAYS PUTNAM, Anna-Maria, A. , KIMMEL, Bruce, E. , CHO, Ho, Sung , SIM, Bee-cheng , LITZINGER, David, C. , MARIANI, Roberto , KRAYNOV, Vadim , KNUDSEN, Nick , DANIEL, Thomas, O. , KODER, Alan , BUSSELL, Stuart , LIU, Junjie , MIAO, Zhenwei , MORROW, Theresa
IPC分类号： C07K14/56
CPC分类号： C07K14/555 , A61K38/00 , C07K14/56
摘要： Modified human interferon polypeptides and uses thereof are provided.
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公开(公告)号：EP2327724A3
公开(公告)日：2011-07-27
申请号：EP11158344.9
申请日：2005-01-28
申请人： AMBRX, INC.
发明人： Cho, Ho Sung , Daniel, Thomas , Dimarchi, Richard , Hays, Anna-Maria , Wilson, Troy , Sim, Bee-Cheng , Litzinger, David
CPC分类号： C07H21/04 , A61K38/21 , A61K38/27 , A61K47/60 , C07K14/475 , C07K14/52 , C07K14/575 , C07K14/61 , C08G65/33396 , G01N33/6875 , G01N2500/00
摘要： Modified human growth hormone polypeptides and uses thereof are provided.
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公开(公告)号：EP2342223A2
公开(公告)日：2011-07-13
申请号：EP09816953.5
申请日：2009-09-25
申请人： Ambrx, Inc. , ELI LILLY AND COMPANY
发明人： TIAN, Feng , HAYS PUTNAM, Anna-Maria, A. , SONG, Frank , CHU, Stephanie , SHEFFER, Joseph , BARNETT, Richard, S. , SILADI, Marc , ATKINSON, Kyle , LEE, Darin , CANNING, Peter, C.
CPC分类号： C07K14/505 , A61K38/00 , A61K38/1816 , A61K47/60 , C12N15/102
摘要： Modified animal erythropoietin polypetides and uses thereof are provide.
摘要翻译： 提供了修饰的动物促红细胞生成素多肽及其用途。
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110.发明授权ACCELERANTS FOR THE MODIFICATION OF NON-NATURAL AMINO ACIDS AND NON-NATURAL AMINO ACID POLYPEPTIDES 有权加速器进行修改不自然的氨基和不自然AMINOSÄUREPOLYPEPTIDE
公开(公告)号：EP1954710B1
公开(公告)日：2011-03-02
申请号：EP06837144.2
申请日：2006-11-08
申请人： Ambrx, Inc.
发明人： TIAN, Feng , MIAO, Zhenwei
IPC分类号： C07C249/08 , C07C249/14 , C07C251/54 , C07K1/107 , C07K14/61 , A61K47/48
CPC分类号： C07K14/61 , C07K1/1077
摘要： Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.
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