公开(公告)号：EP2258840A1

公开(公告)日：2010-12-08

申请号：EP10177452.9

申请日：2000-12-29

申请人： Verenium Corporation

发明人： Madden, Mark ,  Weiner, David Paul ,  Chaplin, Jennifer Ann ,  Robertson, Dan

IPC分类号： C12N9/78 ,  C12P13/04 ,  C12P7/42 ,  C12P41/00

CPC分类号： C12N9/78 ,  C12N15/00 ,  C12P7/42 ,  C12P13/002 ,  C12P13/04 ,  C12P41/006 ,  C12Y305/05001 ,  Y02P20/52

摘要： In accordance with the present invention there are provided methods for producing enantiomerically pure α-substituted carboxylic acids, such as, for example, α-amino acids and α-hydroxy acids, said method comprising an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity which stereoselectively hydrolyzes the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.

摘要翻译： 根据本发明，提供了制备对映体纯的±取代的羧酸的方法，例如± - 氨基酸和± - 羟酸，所述方法包括具有氰化物和氨的醛或酮或 铵盐或胺，在腈水解酶或具有腈水解酶活性的多肽的存在下，在足以产生羧酸的条件下立即选择性水解氨基腈或氰醇中间体。

公开(公告)号：EP2238261A1

公开(公告)日：2010-10-13

申请号：EP08870439.0

申请日：2008-12-22

申请人： Verenium Corporation

发明人： WEINER, David ,  BURKE, Ellen ,  LUGINBUHL, Peter ,  BUENO, Analia ,  CUENCA, Joslin ,  DE SOUZA, Mervyn, L. ,  KOLLMANN, Sherry

IPC分类号： C12Q1/533 ,  C12N9/90 ,  C12N15/61 ,  A61K38/52 ,  C07K16/40

CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re¬ arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

公开(公告)号：EP2205744A2

公开(公告)日：2010-07-14

申请号：EP08797071.1

申请日：2008-08-01

申请人： Verenium Corporation

发明人： GRAY, Kevin, A. ,  DIRMEIER, Reinhard

IPC分类号： C12N15/52 ,  C12N15/09 ,  C12N9/42

CPC分类号： C12P19/14 ,  C12N9/248 ,  C12P19/02 ,  D21H17/22 ,  Y02E50/16 ,  Y02T50/678 ,  Y10T428/249921

摘要： The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal beta-1,4-xylosidic linkages or endo-beta-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.

摘要翻译： 本发明涉及具有木聚糖酶，甘露聚糖酶和/或葡聚糖酶活性的酶，例如催化内部β-1,4-木糖苷键或内切-β-1,4-葡聚糖酶键的水解; 和/或将线性多糖β-1,4-木聚糖降解成木糖。 因此，本发明提供了用于分解半纤维素的方法和工艺，半纤维素是植物细胞壁的主要成分，包括水解任何植物或木材或木材产品，木材废物，纸浆，纸制品中的半纤维素的方法和工艺，或者 废纸或副产品。 另外，还提供了设计新的木聚糖酶，甘露聚糖酶和/或葡聚糖酶的方法及其使用方法。 木聚糖酶，甘露聚糖酶和/或葡聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

公开(公告)号：EP2039762A2

公开(公告)日：2009-03-25

申请号：EP08075753.7

申请日：2002-05-15

申请人： Verenium Corporation

发明人： Desantis, Grace ,  Chaplin, Jennifer, Ann ,  Weiner, David, Paul ,  Milan, Aileen ,  Chi, Ellen ,  Short, Jay, M. ,  Madden, Mark ,  Burk, Mark ,  Robertson, Dan

IPC分类号： C12N9/00 ,  C12N9/78 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C12P1/00 ,  C12P7/00 ,  C12P7/62 ,  C07K1/00

CPC分类号： C12P13/004 ,  C12N9/78 ,  C12P7/42 ,  C12P13/04 ,  C12P41/006

摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition, methods of designing new nitrilases and methods of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 此外，还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。

公开(公告)号：EP1950288A1

公开(公告)日：2008-07-30

申请号：EP08005821.7

申请日：1997-01-10

申请人： Verenium Corporation

发明人： Bylina, Edward J. ,  Swanson, Ronald V. ,  Lam, David E. ,  Mathur, Eric J.

IPC分类号： C12N9/26 ,  C12N1/20 ,  C07H21/04

CPC分类号： C12Y302/01022 ,  C12N9/2402 ,  C12N9/2445 ,  C12N9/2451 ,  C12N9/2454 ,  C12N9/2457 ,  C12N9/2468 ,  C12N9/2471 ,  C12N9/2491 ,  C12N9/2494 ,  C12Y302/01023 ,  C12Y302/01025 ,  C12Y302/01041 ,  C12Y302/01078

摘要： A thermostable glycosidase enzymes derived from various thermococcus, staphylothermus and pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the food processing industry, pharmaceutical industry and in the textile industry, detergent industry and in the baking industry.

摘要翻译： 公开了衍生自各种热球菌，葡萄球菌和热生球菌的热稳定性糖苷酶。 酶由天然或重组宿主细胞产生，可​​用于食品加工业，制药工业，纺织工业，洗涤剂行业和烘焙行业。

公开(公告)号：EP1469066B1

公开(公告)日：2008-04-09

申请号：EP04016461.8

申请日：1997-01-10

申请人： Verenium Corporation

发明人： Bylina, Edward J. ,  Swanson, Ronald V. ,  Mathur, Eric J. ,  Lam, David E.

IPC分类号： C12N9/26 ,  C12N1/20 ,  C07H21/04

CPC分类号： C12Y302/01022 ,  C12N9/2402 ,  C12N9/2445 ,  C12N9/2451 ,  C12N9/2454 ,  C12N9/2457 ,  C12N9/2468 ,  C12N9/2471 ,  C12N9/2491 ,  C12N9/2494 ,  C12Y302/01023 ,  C12Y302/01025 ,  C12Y302/01041 ,  C12Y302/01078

公开(公告)号：EP1003379B1

公开(公告)日：2007-11-07

申请号：EP98940861.2

申请日：1998-08-13

申请人： Verenium Corporation

发明人： SHORT, Jay

IPC分类号： A23B7/10 ,  A23J1/00 ,  C07K16/12

CPC分类号： C12N9/16 ,  A23K20/189 ,  A23L5/25 ,  A23L29/06 ,  C12Y301/03026

摘要： The invention provides a purified phytate enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity (SEQ ID NO:2). The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in animal feed.

公开(公告)号：EP2831257A2

公开(公告)日：2015-02-04

申请号：EP13768384.3

申请日：2013-03-12

申请人： Verenium Corporation

发明人： TAN, Xuqiu ,  BARRETT, Kenneth, E. ,  DAVENPORT, Adrienne, Huston ,  WHIPPLE, Lawrence, E. ,  URBINA, Hugo, D. ,  ZHANG, Bin ,  WALL, Mark, A.

IPC分类号： C12P19/04

CPC分类号： C09K8/68 ,  C09K2208/24 ,  C12N9/2437 ,  C12P19/04 ,  C12P19/14

摘要： Polynucleotide sequences encoding a thermostable cellulase and directing its increased expression are provided, and hydraulic fracturing compositions comprising such thermostable cellulase.

公开(公告)号：EP2069490B1

公开(公告)日：2014-12-03

申请号：EP07869797.6

申请日：2007-12-21

申请人： Verenium Corporation ,  Syngenta Participations AG

发明人： SLUPSKA, Malgorzata ,  HAZLEWOOD, Geoff ,  CHANG, Cathy ,  LUGINBUHL, Peter ,  BURKE, Ellen ,  CAYOUETTE, Michelle ,  GUNAVARDENA, Uvini ,  GHASSEMIAN, Majid ,  SILVERSTONE, Aron ,  ZHANG, Yan

IPC分类号： C12N9/32 ,  C12P21/06 ,  C12N15/00 ,  C12Q1/68 ,  C12N1/20 ,  C12N1/00 ,  C12N15/86 ,  C12P19/04 ,  C12P21/08 ,  C07H21/04 ,  A61K38/47 ,  C12C11/00 ,  A21D2/00 ,  A01K67/027 ,  A01H1/00

CPC分类号： C12N9/96 ,  C12N9/2408 ,  C12N9/2414 ,  C12N9/2425 ,  C12N9/2428 ,  Y02E50/16 ,  Y02E50/17

公开(公告)号：EP2708602A2

公开(公告)日：2014-03-19

申请号：EP13181497.2

申请日：2008-08-01

申请人： Verenium Corporation

发明人： Gray, Kevin ,  Dirmeier, Reinhard

IPC分类号： C12N15/52 ,  C12N15/09 ,  C12N9/42

CPC分类号： C12N9/248 ,  C12P19/02 ,  C12P19/14 ,  D21H17/22 ,  Y02E50/16 ,  Y02T50/678 ,  Y10T428/249921

摘要： The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo- β-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.

摘要翻译： 本发明涉及具有木聚糖，甘露聚糖酶和/或葡聚糖酶活性，E. G.，内部²-1,4-木糖苷键的水解催化或内²-1,4-葡聚糖键的酶; 和/或降解的线性多糖β-1,4-木聚糖为木糖。 因此，本发明提供的方法和过程用于分解半纤维素，所有这些是植物，包括的方法和过程的细胞壁的用于任何植物或木材或木制品，废木料，纸浆，纸制品或水解半纤维素的主要成分 废纸或副产品。 此外，它们因此，提供设计新的木聚糖酶，甘露的NAS和/或葡聚糖酶和使用方法的方法。 所述木聚糖酶，甘露的NAS和/或葡聚糖酶具有增加的pH值和温度增加的活性和稳定性。