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13 条记录 (耗时 0.039 秒)

    ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
    9.
    发明授权
    ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
    用于生产NUCLEIC为她和使用醛缩酶编码及方法

    公开(公告)号：EP1999256B1

    公开(公告)日：2012-03-07

    申请号：EP07758102.3

    申请日：2007-03-07

    申请人： Verenium Corporation

    发明人： BURKE, Ellen ,  HICKS, Paula, M. ,  LUGINBUHL, Peter ,  RICHARDSON, Toby ,  WEINER, David, P. ,  ZHAO, Lishan

    IPC分类号： C12N9/10

    CPC分类号： C12N9/88 ,  A01K2217/05 ,  A61K38/00 ,  C07K2317/92 ,  C12N9/1022 ,  C12N15/8243 ,  C12P17/10 ,  C12Y401/03016 ,  C12Y401/03017 ,  Y02E50/16 ,  Y02E50/17

    摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S, R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S, R configurations, and salts thereof.

    TRANSFERASES AND OXIDOREDUCTASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
    10.
    发明授权
    TRANSFERASES AND OXIDOREDUCTASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
    转移酶，和氧化还原酶，用于生产和使用的核酸编码AND METHOD

    公开(公告)号：EP2238242B1

    公开(公告)日：2014-11-26

    申请号：EP08869698.4

    申请日：2008-12-31

    申请人： Verenium Corporation

    发明人： WEINER, David ,  LUGINBUHL, Peter ,  BUENO, Analia ,  CUENCA, Joslin ,  MARASCO, Erin

    IPC分类号： C12N9/10 ,  C12N9/02 ,  C12Q1/48 ,  C12Q1/26 ,  C07K14/38 ,  C07K16/40 ,  C07K9/00 ,  A61K38/44 ,  A61K38/45

    CPC分类号： C12N9/1096 ,  A21D8/042 ,  A61K38/00 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/0014 ,  C12N9/10 ,  C12N15/1137 ,  C12N15/63 ,  C12N15/86 ,  C12P7/10 ,  C12Q1/6876 ,  C12Y206/01021 ,  D06L4/40 ,  D06M16/003 ,  G01N33/573 ,  Y02E50/16 ,  Y02P20/52 ,  Y02T50/678

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., damino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine + 2-oxoglutarate pyruvate + D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid + H 2 O + acceptor a 2-oxo acid + NH 3 + reduced acceptor. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明涉及基因的反弹到酶，多核苷酸更具体编码酶，使用搜索多核苷酸和多肽的，并具有转移酶活性，例如转氨酶活性，例如d-氨基酸酸转移酶活性，和/或氧化还原酶活性，例如酶 脱氢酶活性，例如，Damino酸脱氢酶活性，和/或催化化学基团的转移，催化转氨基，催化反应：D-丙氨酸+ 2-酮戊二酸丙酮酸<=> + D-谷氨酸，和/或催化 到氧化还原反应，催化除去氢原子的，和/或催化下列反应：D-氨基酸+ H 2 O +受体<=> 2-含氧酸+ NH 3 +还原的受体。 因此，本发明提供的酶，组合物，方法用于制备药物组合物，医药中间体，抗生素，甜味剂，肽酶，肽类激素，燃料，燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆，和洗涤剂包括以本发明在雅舞蹈的多肽或多核苷酸。