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    MINIMALLY INVASIVE SPLAYING MICROFIBER ELECTRODE ARRAY AND METHODS OF FABRICATING AND IMPLANTING THE SAME
    103.
    发明公开
    MINIMALLY INVASIVE SPLAYING MICROFIBER ELECTRODE ARRAY AND METHODS OF FABRICATING AND IMPLANTING THE SAME 审中-公开
    根据上述制造和IT植入微创SPREAD和方法微纤维电极装置

    公开(公告)号：EP3016585A2

    公开(公告)日：2016-05-11

    申请号：EP14820220.3

    申请日：2014-07-07

    申请人： Trustees of Boston University

    发明人： GARDNER, Timothy James ,  LIBERTI, William ,  MARKOWITZ, Jeffrey ,  GUITCHOUNTS, Grigori

    IPC分类号： A61B5/04

    CPC分类号： A61N1/0529 ,  A61B5/04001 ,  A61B5/685 ,  A61B5/6868 ,  A61B5/6877 ,  A61B2562/0209 ,  A61B2562/125 ,  A61N1/0534 ,  A61N1/0551

    摘要： An electrode array having a splayable bundle of fibers having heat-sharpened tips. A method of manufacturing an electrode array including heat-sharpening a tip of each of a plurality of fibers; and bundling the plurality of fibers. A method of implanting an electrode array into a subject, the electrode array having a bundle of fibers, the method including exposing a target in the subject for the electrode array; and inserting the bundle of fibers into the target, where forces holding the bundle of fibers together are released during the insertion thus resulting in splaying of the fibers. An electrical connection with the fibers can be formed by a conductive material, or in high-channel count designs formed by surface mounting two-dimensional amplifier arrays to a base of a fiber array.

    摘要翻译： 具有具有耐热锐化尖端纤维束能够张开的电极阵列。 制造电极阵列包括的方法热锐化各纤维的多个的尖端; 捆扎纤维的多元性。 植入电极阵列的入受试者的方法，具有纤维束的电极阵列，所述方法包括在所述电极阵列的对象曝光的目标; 和插入纤维束到目标，在那里保持纤维束的力一起被插入在纤维的张开从而导致过程中释放。 与纤维的电连接，可以形成由导电性材料，或在通过表面安装二维阵列放大器到光纤阵列的碱形成高通道数的设计。

    BLOOD GLUCOSE CONTROL SYSTEM
    105.
    发明公开
    BLOOD GLUCOSE CONTROL SYSTEM 有权
    SYSTEMFÜRBLUTZUCKERKONTROLLE

    公开(公告)号：EP2633456A1

    公开(公告)日：2013-09-04

    申请号：EP11785841.5

    申请日：2011-10-31

    申请人： Trustees of Boston University

    发明人： EL-KHATIB, Firas ,  DAMIANO, Edward

    IPC分类号： G06F19/00

    CPC分类号： A61M5/1723 ,  A61M5/14244 ,  A61M5/14248 ,  A61M2005/1402 ,  A61M2005/14208 ,  A61M2202/07 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3462 ,  G06F19/3468 ,  G16H20/13 ,  G16H20/17 ,  G16H50/50

    摘要： Techniques are used for adaptation of drug-administration parameters that control insulin delivery in a blood glucose control system. One technique provides long-term adaptation of a nominal basal infusion rate, adapting to longer-term changes in a patient's needs due to growth, illness, hormonal fluctuations, physical activity, aging, etc. Another technique provides adaptation of priming dose size at mealtimes for overall better glycemic control and also adapting to longer-term changes in a patient's needs. Adaptation calculations use a receding-horizon window of recent values of the adapted parameter. Doses of a counter-regulatory agent (e.g., glucagon) may also be delivered in response to information about estimated accumulation of exogenously infused insulin (subcutaneously, intramuscularly, intraperitoneally, or intravenously) and/or the effect insulin might have on glucose levels (blood glucose concentration or interstitial fluid glucose concentration).

    摘要翻译： 技术用于调节血糖控制系统中控制胰岛素输送的药物给药参数。 一种技术可以提供名义基础输注速率的长期适应性，适应由于生长，疾病，激素波动，身体活动，衰老等而导致的患者需求的长期变化。另一种技术提供了在进餐时启动剂量大小的适应 用于总体更好的血糖控制，并适应患者需求的长期变化。 适应性计算使用适应参数的最近值的后退视窗。 响应于关于外源性输注胰岛素（皮下，肌内，腹膜内或静脉内）的估计积累的信息和/或胰岛素可能对葡萄糖水平（血液）的影响，还可以递送反调节剂（例如，胰高血糖素）的剂量 葡萄糖浓度或间质液葡萄糖浓度）。