摘要:
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by structural formula (I) and physiologically acceptable salts thereof.
摘要:
An industrially more advantageous method for the production of metabolites biologically synthesized via phosphoribosyl pyrophosphate (PRPP) is provided, making use of metabolically modified strains in which transketolase activity is deficient or reduced in comparison with the parent strain.
摘要:
The present invention relates to a whey mineral containing at least 0.8 g/kg or above of zinc and to a process for producing the same. The whey mineral of the present invention have good flavors and are useful in liquid formula, medical foods, nourishing reinforced foods, functional foods, seasonings, etc.
摘要:
The present invention relates to a whey mineral containing at least 0.8 g/kg or above of zinc and to a process for producing the same. The whey mineral of the present invention have good flavors and are useful in liquid formula, medical foods, nourishing reinforced foods, functional foods, seasonings, etc.
摘要:
Disclosed are a process for producing aspartase which comprises culturing a microorganism belonging to the genus Escherichia being capable of producing aspartase in a medium until aspartase is produced and accumulated in the culture, and recovering aspartase therefrom, wherein dissolved oxygen concentration of the medium is in the range of 0 to 1 ppm on the stage that microbial growth is middle and/or late logarithmic growth phase; and a process for producing L-aspartic acid which comprises converting fumaric acid and ammonia into L-aspartic acid in an aqueous medium in the presence of an enzyme source, wherein said enzyme source is a culture produced in accordance with said aspartase-producing process, cells isolated from the culture, or processed cells thereof.
摘要:
A process for producing L-alanine which comprises culturing a micro-organism which belongs to the genus Arthrobacter, has an L-alaline dehydrogenase activity and scarcely any or no alanine racemase activity, and is capable of producing L-alanine in a medium, accumulating the produced L-alanine in the media, and separating L-alanine thereform.
摘要:
An adenosine incorporation inhibitor and a drug for protecting cardiac muscles or preventing or treating inflammatory edema, each containing as the active ingredient a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R¹ represents hydrogen, (un)substituted lower alkyl, alkenyl or (un)substituted aralkyl; R², R³, R⁴ and R⁵ represent each independently hydrogen, halogen, amino, mono- or di(lower alkyl) amino, lower alkanoyl amino, nitro, cyano, (un)substituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy or lower alkanoyloxy; R⁶, R⁷, R⁸ and R⁹ represent each independently hydrogen, hydroxy, (un)substituted lower alkoxy or aralkyloxy, or alternatively the two adjacent groups among them may be combined together to represent methylenedioxy; R¹⁰ represents hydrogen or lower alkyl; and Y and Z represent each independently N or C-R'', wherein R'' represents hydrogen, (un)substituted lower alkyl or halogen.
摘要翻译:一种腺苷结合抑制剂和保护心肌的药物或预防或治疗炎性水肿的药物,每种药物含有作为活性成分的由通式(I)表示的1,2,3,4-四氢-2,4-二氧代喹唑啉衍生物或 其中R 1代表氢,(未)取代的低级烷基,烯基或(未)取代的芳烷基; (低级烷基)氨基,低级烷酰基氨基,硝基,氰基,(未)取代的低级烷基,羟基,低级烷氧基,低级烷硫基,羧基 ,低级烷氧基羰基,低级烷酰基,芳烷氧基或低级烷酰氧基; R 8,R 8和R 8各自独立地代表氢,羟基,(未)取代的低级烷氧基或芳烷氧基,或者它们中的两个相邻基团可以结合在一起表示亚甲二氧基; R 10代表氢或低级烷基; Y和Z各自独立地代表N或C-R“,其中R”代表氢,(未)取代的低级烷基或卤素。
摘要:
A thrombocytopenia remedy containing an indolocarbazole derivative represented by general formula (I) or a pharmacologically acceptable salt thereof as the active ingredient, and a novel indolocarbazole derivative.
摘要:
A process for producing alanine which comprises culturing in a medium a microorganism belonging to the genus Escherichia , Corynebacterium or Brevibacterium which has an L-alanine dehydrogenase activity and is capable of producing alanine, allowing the microorganism to produce and accumulate alanine in the culture medium, and recovering alanine from the culture medium.