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公开(公告)号：EP0754030B1
公开(公告)日：2000-12-20
申请号：EP95918749.3
申请日：1995-05-19
IPC分类号： A61K9/14 , A61K47/26 , A61K47/02 , A61K31/495
CPC分类号： A61K9/19 , A61K9/0019 , A61K31/495 , A61K47/02 , A61K47/26
摘要： Stabilized duocarmycin derivatives represented by formula (I), wherein R is lower alkyl, allyl or benzyl, and X is C1 or Br, are prepared by adding at least a compound selected from the group consisting of a saccharide, an electrolyte, a water-soluble polymer, a polyhydric alcohol and a surfactant to a solution containing the duocarmycin derivatives. Also provided are freeze-dried pharmaceutical preparations containing the stabilized duocarmycin derivatives.
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112.发明公开
公开(公告)号：EP1043028A1
公开(公告)日：2000-10-11
申请号：EP98961423.5
申请日：1998-12-18
发明人： HOKASE, Masanobu
CPC分类号： A61K38/465 , A23K20/189 , A23K20/30 , C12Y301/03008
摘要： The present invention provides a novel method for preventing and treating mastitis in mammals and a composition for use in the method to prevent reduction in milk production caused by development of mastitis among livestock such as dairy cows, the invention being based on the finding that mastitis in mammals can be prevented and treated by administering phytase to the mammals.
摘要翻译： 本发明提供了一种用于预防和治疗哺乳动物中的乳腺炎的新方法，以及用于防止乳牛发病引起的乳制品发生减少的方法中的组合物，所述乳制品在诸如奶牛的家畜中发生，本发明是基于以下发现： 通过向哺乳动物施用植酸酶可以预防和治疗哺乳动物。
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公开(公告)号：EP0573659B1
公开(公告)日：2000-07-12
申请号：EP92924885.4
申请日：1992-12-07
发明人： SUZUKI, Fumio 18-4, Fujimidai , NAKASATO, Yoshisuke 1188, Shimotogari , OHMORI, Kenji 2-14-6, Fuyodai , TAMURA, Tadafumi 3198-3, Ooka , SATO, Soichiro 564-5, Nakatogari Nagaizumi-cho , TANAKA, Hiroshi 2-31-13, Ishidai
IPC分类号： C07D513/14 , A61K31/505 , A61K31/54 , A61K31/55
CPC分类号： C07D513/14
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114.发明公开Humanized chimeric antibody directed against ganglioside GD3 失效HumanisiertechimärenAntikörpergegen das神经节苷脂GD3
公开(公告)号：EP1013761A2
公开(公告)日：2000-06-28
申请号：EP99124345.2
申请日：1992-09-18
IPC分类号： C12N15/12 , C07K16/46 , C07K16/18 , A61K39/395 , C12N15/64
CPC分类号： C07K16/3084 , A61K38/00 , A61K2039/505 , C07K16/18 , C07K16/462 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/02
摘要： The present invention discloses a process for the production of humanized chimera antibody, wherein the chimera antibody is produced easily without changing any of the amino acids of its mouse antibody variable region. The invention relates to humanized chimera antibodies obtainable by the claimed process and being reactive with ganglioside GD 3 , to transformants capable of producing said humanized chimera antibodies, to pharmaceutical compositions comprising said humanized chimera antibodies, and the use of these antibodies for treating cancer.
摘要翻译： 本发明公开了一种生产人源化嵌合体抗体的方法，其中所述嵌合体抗体容易生产，而不改变其小鼠抗体可变区的任何氨基酸。 本发明涉及可通过所要求保护的方法获得的人源化嵌合体抗体，其能够与神经节苷脂GD3反应，能够产生所述人源化嵌合体抗体的转化体，包含所述人源化嵌合体抗体的药物组合物，以及这些抗体用于治疗癌症的用途。
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115.发明公开MONOCLONAL ANTIBODY AGAINST HUMAN TELOMERASE CATALYTIC SUBUNIT 审中-公开MONOKLONALERANTIKÖRPERGEGEN DIE KATALYTISCHE UNTEREINHEIT DER TELOMERASE。
公开(公告)号：EP0990701A1
公开(公告)日：2000-04-05
申请号：EP99910727.9
申请日：1999-03-26
发明人： HANAI, Nobuo , YAMASAKI, Motoo , SHIBATA, Kenji , FURUYA, Akiko , MIKUNI, Osamu , ANAZAWA, Hideharu
IPC分类号： C12N15/06 , C12N15/13 , C07K16/40 , C12N5/18 , A61K39/395 , G01N33/543 , G01N33/53 , G01N33/569 , G01N33/50
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/624 , G01N33/573
摘要： A monoclonal antibody capable of specifically and effectively recognizing hTERT protein which is the catalytic subunit of telomerase; a human chimeric antibody, a CDR transplantation antibody, a single-stranded antibody and a disulfide stabilizing antibody each containing the above monoclonal antibody; a method for detecting/quantitating hTERT protein by using these antibodies; and diagnostic methods, diagnostics and remedies for various diseases such as cancer in which telomerase participates.
摘要翻译： 能够特异性有效识别作为端粒酶催化亚基的hTERT蛋白的单克隆抗体; 每个含有上述单克隆抗体的人嵌合抗体，CDR移植抗体，单链抗体和二硫键稳定抗体; 通过使用这些抗体检测/定量hTERT蛋白的方法; 以及各种疾病（如端粒酶参与的癌症）的诊断方法，诊断和治疗方法。
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公开(公告)号：EP0860170B1
公开(公告)日：2000-03-22
申请号：EP97934768.9
申请日：1997-08-12
发明人： HAYAKAWA, Eiji , MIURA, Shigemitsu , ITO, Kunio , SAKATO, Kuniaki
CPC分类号： A61K51/1206 , A61K31/17 , A61K51/1258
摘要： Tablets comprising isotopic urea and an inorganic compound. Tableting a mixture of the urea with one or more inorganic compounds (additives) can inhibit the adhesion due to cohesiveness of urea and can give tablets having a practical disintegration time and sufficiently high hardness. The tablets are useful for the diagnosis of infections with urease-producing microorganisms containing isotopic urea, particularly the one with Helicobacter pylori.
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公开(公告)号：EP0670317B1
公开(公告)日：2000-03-08
申请号：EP94927068.0
申请日：1994-09-20
发明人： KANEKO, Masami , SAITOH, Yutaka , AKINAGA, Shiro , OKABE, Masami , AKASAKA, Kazuhito , NAKANO, Hirofumi
IPC分类号： C07D303/36 , A61K31/335
CPC分类号： C07D303/36
摘要： An epoxycyclohexenedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents C10-C25 linear or branched alkanoyl, C10-C25 linear alkenoyl or a group represented by formula (A), wherein n represents an integer of 1 to 4. This compound has antibacterial and antitumoral activities.
摘要翻译： 通式（I）表示的环氧基环己二酮衍生物或其药理学上允许的盐，式中，R表示碳原子数10〜25的直链状或支链状的烷酰基，碳原子数10〜25的直链烯酰基或式（A）所示的基团， 到4.这种化合物具有抗菌和抗肿瘤活性。
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公开(公告)号：EP0549352B1
公开(公告)日：2000-03-01
申请号：EP92311777.4
申请日：1992-12-24
发明人： Ohshima, Etsuo , Kanai, Fumihiko , Sato, Hideyuki , Obase, Hiroyuki , Kumazawa, Toshiaki , Takahara, Shiho , Ohno, Tetsuji , Ishikawa, Tomoko , Yamada, Koji
IPC分类号： C07D471/04 , A61K31/435 , A61K31/41 , A61K31/55 , A61K31/54 , C07D405/06 , C07D519/00 , C07D405/14 , C07D403/14 , C07D403/06 , C07D401/12
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D471/04
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公开(公告)号：EP0857789A3
公开(公告)日：1999-12-22
申请号：EP98300789.9
申请日：1998-02-04
发明人： Ago, Shoji , Kikuchi, Yasuhiro
摘要： The present invention relates to a protein having the amino acid sequence represented by SEQ ID NO: 1, or a protein having ferulic acid decarboxylase activity and having an amino acid sequence wherein one or more amino acid residues are deleted, substituted or added in the amino acid sequence represented by SEQ ID NO: 1; a gene encoding said protein; a recombinant vector comprising said gene; a transformant carrying said recombinant vector; a process for producing 4-vinylguaiacol, vanillin or vanillic acid, or a distilled liquor, wherein an enzyme source having ferulic acid decarboxylase activity which is derived from said transformant is used; and a process for producing a distilled liquor, wherein yeast having an enhanced ferulic acid decarboxylase activity is used.
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120.发明公开
公开(公告)号：EP0914779A3
公开(公告)日：1999-12-08
申请号：EP98309032.5
申请日：1998-11-04
CPC分类号： A23L2/66 , A23C11/08 , A23L33/19 , Y10S426/80 , Y10S426/801
摘要： Disclosed are a method for producing a protein-containing acidic food and drink that comprises processing a protein emulsion having a pH value that is higher than the isoelectric point of the protein in the emulsion at a high temperature to make the emulsion having a pH value that is lower than the isoelectric point of the protein; the protein-containing acidic food and drink produced in the method; protein-containing acidic food and drink containing protein, fat and oil, and water-soluble polysaccharide, in which the particles dispersed have a mean particle size of not greater than 15 µm; and a protein-containing acidic drink containing protein, fat and oil, and water-soluble polysaccharide, in which the particles dispersed have a mean particle size of not greater than 15 µm and/or having a viscosity not greater than 20 centipoises (cPs). The protein-containing acidic food and drink is smooth, tasteful, palatable and has good storage stability.
摘要翻译： 公开了一种生产含蛋白质的酸性食品和饮料的方法，其包括在高温下处理pH值高于乳液中的蛋白质的等电点的蛋白质乳液，使乳液的pH值为 低于蛋白质的等电点; 该方法生产的含蛋白质的酸性食品和饮料; 含有蛋白质，脂肪和油的含蛋白质的酸性食品和饮料以及其中分散的颗粒的平均粒度不大于15μm的水溶性多糖; 和含有蛋白质，脂肪和油的蛋白质的酸性饮料和水溶性多糖，其中分散的颗粒的平均粒度不大于15μm和/或具有不大于20厘泊的粘度（cPs ）。 含蛋白质的酸性食品和饮料是光滑，雅致，可口，具有良好的储存稳定性。
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