公开(公告)号：EP1291020A3

公开(公告)日：2004-05-26

申请号：EP02024061.0

申请日：1998-11-05

申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： Horwitz, David A.

IPC分类号： A61K35/14 ,  A61P37/02

CPC分类号： C12N5/0634 ,  A61K35/15 ,  A61K35/17 ,  C12N2501/15 ,  C12N2501/23 ,  C12N2501/599

摘要： Method for ex-vivo inhibition of the production of immunoglobulins in a sample of peripheral blood mononuclear cells (PBMC) by addition of an inhibitory composition (e.g. containing IL-2 or TGF-beta as inhibitor agent) to the cells. Method of treating autoimmune diseases, e.g. systematic lupus erythematosus (SLE), by reintroducing the treated cells to a patient.

公开(公告)号：EP0662087B1

公开(公告)日：2003-10-01

申请号：EP93914393.9

申请日：1993-06-04

申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： JOHNSON, Lincoln, V. ,  TOMBRAN-TINK, Joyce

IPC分类号： C12N15/12 ,  C07K14/475 ,  C07K14/81

CPC分类号： C07K14/811 ,  A61K38/00 ,  C07K14/475

摘要： The present invention relates to a purified retinal pigmented epithelium derived neurotrophic factor composition and a method for purifying such a retinal pigmented epithelium neurotrophic factor. The present invention also relates to a recombinant DNA molecule comprising a gene encoding a retinal pigmented epithelium derived neurotrophic factor having the DNA sequence or the amino acid sequence in SEQ ID NO 1 and to an organism transformed with the recombinant DNA molecule. In addition, the present invention relates to a method of treating tumors, ocular diseases, nerve injuries, and conditions resulting from the activity of serine proteases, which comprises administering retinal epithelium derived neurotrophic factor.

公开(公告)号：EP1326675A1

公开(公告)日：2003-07-16

申请号：EP01966617.1

申请日：2001-09-07

申请人： Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California

发明人： LOEB, Gerald, E. ,  RICHMOND, Frances, J., R.

IPC分类号： A61N1/05

CPC分类号： A61N1/36007 ,  A61N1/37205 ,  A61N1/3756

摘要： The invention includes microminiature electronic devices (10, 20) implanted in or around the large bowel to sense the volume and nature of rectal contents and to stimulate peristaltic constractions to empty the large bowel.

公开(公告)号：EP1044586A2

公开(公告)日：2000-10-18

申请号：EP98953300.5

申请日：1998-10-08

申请人： The Trustees of Princeton University ,  THE UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： FORREST, Stephen, R. ,  BURROWS, Paul ,  PARTHASARATHY, Gautam ,  O'BRIEN, Diarmuid ,  THOMPSON, Mark, E. ,  YU, Yujian ,  SHOUSTIKOV, Andrei ,  PETASIS, Nicos, A. ,  SIBLEY, Scott ,  LOY, Douglas, ,  KOENE, Brian, E. ,  KWONG, Raymond, C.

IPC分类号： H05B33/28

CPC分类号： H01L51/5016 ,  C07C211/61 ,  C07C2603/18 ,  C07C2603/26 ,  C07D223/14 ,  C07D223/26 ,  C07D403/10 ,  C07D487/22 ,  C09K11/06 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1074 ,  C09K2211/185 ,  C09K2211/186 ,  H01L51/0008 ,  H01L51/0021 ,  H01L51/0052 ,  H01L51/0053 ,  H01L51/0059 ,  H01L51/0072 ,  H01L51/0078 ,  H01L51/0079 ,  H01L51/0081 ,  H01L51/0084 ,  H01L51/0091 ,  H01L51/0092 ,  H01L51/5012 ,  H01L51/5048 ,  H01L51/5092 ,  H01L51/5234 ,  H01L2251/308 ,  H01L2251/5315 ,  H01L2251/5323 ,  H05B33/14 ,  H05B33/28

摘要： A novel class of low reflectivity, high transparency, non-metallic cathodes (1) useful for a wide range of electrically active, transparent organic devices is disclosed. As a representative embodiment, the highly transparent non-metallic cathode (1) of an OLED employes a thin film of copper phthalocyanine (CuPc) (6) capped with a film of low-power, radio-frequency sputtered indium-tin-oxide (ITO). The CuPc prevents damage to the underlying organic layers during the ITO sputtering process. Due to the low reflectivity of the non-metallic cathode, a non-antireflection-coated, non-metallic-cathode-containing TOLED is disclosed that is 85 % transmissive in the visible, emitting nearly identical amounts of light in the forward and back-scattered directions.

摘要翻译： 本发明涉及一种用于制造电致发光器件，该器件包括一种有机发光器件，该有机发光器件包括由磷光材料和载电子载体材料构成的发光层，其中当磷光发光材料发生磷光发射时， 电压施加在有机发光器件上。

公开(公告)号：EP0538443B1

公开(公告)日：1997-10-01

申请号：EP92910686.2

申请日：1992-04-10

申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： SPICER, Darcy, Vernon ,  PIKE, Malcolm, Cecil

IPC分类号： A61K9/14

CPC分类号： A61K38/09 ,  A61K9/0036 ,  A61K9/1647 ,  Y10S424/14 ,  Y10S514/80 ,  Y10S514/841 ,  Y10S514/842 ,  Y10S514/843 ,  Y10S530/85 ,  Y10S530/853 ,  A61K31/57 ,  A61K31/565 ,  A61K31/05 ,  A61K2300/00

摘要： Compositions and methods which are effective to inhibit conception and to treat benign gynecological disorders for extended periods of time are described, wherein an effective amount of a gonadotropin hormone releasing hormone composition and an effective amount of an estrogenic composition are provided over a first period of time, in addition to a progestogen and optionally an androgenic composition. According to one protocol, the progestogen is provided for a second, shorter period of time; the progestogen is provided at a higher level for at least 5 to about 20 days, and then at a lower level for the remainder, if any, of the second period of time. In an alternative protocol, the progestogen is provided at a lower level substantially throughout the period of administration of gonadotropin hormone releasing hormone composition and estrogenic composition. An effective amount of the androgenic hormone is optionally provided over the first period of time.

公开(公告)号：EP0755576A1

公开(公告)日：1997-01-29

申请号：EP95900379.0

申请日：1994-10-18

申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： SURAMPUDI, Subbarao ,  NARAYANAN, Sekharipuram R. ,  VAMOS, Eugene ,  FRANK, Harvey A. ,  HALPERT, Gerald ,  OLAH, George A. ,  PRAKASH, G.K. Surya

IPC分类号： H01M4 ,  H01M8

CPC分类号： H01M4/8605 ,  H01M4/8853 ,  H01M4/8892 ,  H01M4/921 ,  H01M4/926 ,  H01M4/928 ,  H01M8/04119 ,  H01M8/04186 ,  H01M8/1004 ,  H01M8/1009 ,  H01M8/1023 ,  H01M8/1039 ,  H01M8/1041 ,  H01M8/1046 ,  H01M8/22 ,  H01M8/2455 ,  H01M2004/8684 ,  H01M2300/0082 ,  Y02P70/56

摘要： A liquid organic fuel cell (10) is provided which employs a solid electrolyte membrane (18). An organic fuel, such as methanol/water mixture, is circulated past an anode (14) of the cell while oxygen or air is circulated past a cathode (16). The cell electrolyte membrane is preferably made of NafionTM. Also, a method for improving the performance of carbon electrode structures is provided, wherein a high-surface-area carbon particle/TeflonTM binder structure is immersed within a NafionTM/methanol bath to impregnate the electron with NafionTM. A method of fabricating an anode for this fuel cell is described, wherein metal alloys are deposited onto the electrode from a solution containing perfluorooctanesulfonic acid. A fuel additive containing this acid, and new organic fuels are also described.

公开(公告)号：EP0748191A1

公开(公告)日：1996-12-18

申请号：EP94917357.0

申请日：1994-05-12

申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： PIKE, Malcolm, Cecil ,  SPICER, Darcy, Vernon

IPC分类号： A61K9 ,  A61K31 ,  A61K38

CPC分类号： A61K31/565 ,  A61K9/0036 ,  A61K9/1647 ,  A61K31/57 ,  A61K38/09 ,  A61K2300/00

摘要： Compositions and methods which are effective to prevent symptoms of loss of ovarian function (e.g., in oophorectomized women) over a period of time are described, consisting essentially of an effective amount of an estrogenic composition and an effective amount of an androgenic composition. The levels of estrogens and androgens employed are sufficient to reduce bone mineral density loss and minimize other side effects observed after oophorectomy, and at such low doses as to minimize any adverse impact on the patient's long-term prognosis or (in the case of testosterone) result in additional side effects.

公开(公告)号：EP0748190A1

公开(公告)日：1996-12-18

申请号：EP94917349.0

申请日：1994-05-12

申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： PIKE, Malcolm, Cecil ,  SPICER, Darcy, Vernon

IPC分类号： A61K9 ,  A61K38

CPC分类号： A61K9/1647 ,  A61K9/0036 ,  A61K38/09 ,  Y10S424/14 ,  A61K31/567 ,  A61K31/566 ,  A61K31/565 ,  A61K2300/00

摘要： Compositions and methods which are effective to treat benign gynecological disorders for extended periods of time in women in who the risk of endometrial stimulations is minimized or absent are described, wherein an effective amount of a gonadotropin hormone releasing hormone composition and an effective amount of an estrogenic composition are provided over a period of time, optionally with addition of an androgenic composition.

公开(公告)号：EP0745091A1

公开(公告)日：1996-12-04

申请号：EP94929230.0

申请日：1994-09-19

申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： RODGERS, Kathleen Elizabeth ,  DIZEREGA, Gere Stodder

IPC分类号： C12N15 ,  A61K9 ,  A61K38 ,  A61L15 ,  A61P17 ,  A61P43 ,  C07K7

CPC分类号： C07K7/14 ,  A61K38/00

摘要： Analogs of angiotensin II are useful in accelerating wound healing. These analogs form the basis of compositions useful for accelerating wound healing, in which the active agent is present in an amount effective to accelerate wound healing. Preferably, the compositions are in the form of matrical or micellar solutions.

公开(公告)号：EP0722973A1

公开(公告)日：1996-07-24

申请号：EP96300113.6

申请日：1996-01-05

申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA ,  Orthopaedic Hospital

发明人： Salovey, Ron ,  Shen, Fu-Wen ,  McKellop, Harry A.

IPC分类号： C08J3/24 ,  C08J3/28 ,  A61F2/30

CPC分类号： A61F2/30 ,  A61F2/3094 ,  A61F2/32 ,  A61F2/34 ,  A61F2/468 ,  A61F2002/30233 ,  A61F2002/3082 ,  A61F2002/30879 ,  A61F2002/3611 ,  A61F2230/0069 ,  A61L27/16 ,  B29B13/08 ,  B29C43/00 ,  B29C43/16 ,  B29C71/0063 ,  B29C2035/085 ,  B29K2023/0683 ,  B29K2105/24 ,  B29K2995/0087 ,  B29K2995/0089 ,  B29L2031/7532 ,  C08J5/00 ,  C08J7/047 ,  C08J2323/06 ,  C08L23/06

摘要： The present invention discloses a method for enhancing the wear-resistance of polymers by crosslinking them, especially before irradiation sterilization. In particular, this invention presents the use of chemically crosslinked ultrahigh molecular weight polyethylene in in vivo implants.

摘要翻译： 本发明公开了一种提高聚合物的耐磨性的方法，特别是在辐射灭菌之前，通过交联聚合物的耐磨性。 特别地，本发明提出了在体内植入物中使用化学交联的超高分子量聚乙烯。