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111.OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 有权
标题翻译: OPSINBINDENDE LIGANDEN SOWIE ZUSAMMENSETZUNGEN DARAUS UND VERWENDUNGSVERFAHRENDAFÜR公开(公告)号:EP2442644B1
公开(公告)日:2016-08-10
申请号:EP10789866.0
申请日:2010-06-16
发明人: GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, Robert , BREWER, Mark, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
IPC分类号: A61K31/11 , A61P27/02 , C07D207/12 , C07D207/14 , C07D243/08 , C07D491/10 , C07D493/08
CPC分类号: C07D295/215 , C07B59/002 , C07B2200/05 , C07C233/10 , C07C275/14 , C07C2601/16 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/38 , C07D241/04 , C07D241/08 , C07D243/08 , C07D295/182 , C07D295/185 , C07D295/194 , C07D295/205 , C07D295/26 , C07D491/10 , C07D493/08
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公开(公告)号:EP2890676A4
公开(公告)日:2016-04-20
申请号:EP13834078
申请日:2013-08-29
IPC分类号: C07D207/14 , A61K31/40 , A61K31/428 , A61K31/4439 , A61P25/28 , C07D401/06 , C07D417/06 , C07H13/02 , C12N9/24
CPC分类号: C07D417/06 , C07D207/14 , C07D401/06 , C07D401/08
摘要: The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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113.C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS 有权
标题翻译: C7-FLUOR-SUBSTITUIERTE TETRACYCLINVERBINDUNGEN公开(公告)号:EP3000805A1
公开(公告)日:2016-03-30
申请号:EP15180611.4
申请日:2009-08-07
发明人: Zahler, Robert B. , Clark, Roger B. , Hunt, Diana Katharine , Plamondon, Louis , Xiao, Xiao-Yi , Zhou, Jingye
IPC分类号: C07C311/08 , C07C311/21 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12
CPC分类号: C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要: The present invention is directed to a compound represented by Structural Formula (A):
or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.摘要翻译: 本发明涉及由结构式(A)表示的化合物或其药学上可接受的盐。 结构式(A)的变量在本文中定义。 还描述了包含结构式(A)的化合物及其治疗用途的药物组合物。
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公开(公告)号:EP2134680B1
公开(公告)日:2016-01-13
申请号:EP08733559.2
申请日:2008-03-12
申请人: MethylGene Inc.
发明人: FRECHETTE, Sylvie , ISAKOVIC, Lubo , PAQUIN, Isabelle , ROY, Simon , MORADEI, Oscar , VAISBURG, Arkadii
IPC分类号: C07D207/14 , A61K31/40 , A61K31/4025 , A61K31/4439 , A61K31/5377 , A61P35/00 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12
CPC分类号: C07D401/12 , C07D207/14 , C07D401/04 , C07D403/04 , C07D405/12
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115.
公开(公告)号:EP2890676A1
公开(公告)日:2015-07-08
申请号:EP13834078.1
申请日:2013-08-29
IPC分类号: C07D207/14 , A61K31/40 , A61K31/428 , A61K31/4439 , A61P25/28 , C07D401/06 , C07D417/06 , C07H13/02 , C12N9/24
CPC分类号: C07D417/06 , C07D207/14 , C07D401/06 , C07D401/08
摘要: The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
摘要翻译: 本发明提供了用于抑制糖苷酶的化合物,化合物的前药以及包含化合物的化合物或前药的药物组合物。 本发明还提供治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法,O-GlcNAc的积累或缺乏。
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116.DYE COMPOSITION COMPRISING A CATIONIC O-ALKYL-SUBSTITUTED META-PHENYLENEDIAMINE DERIVATIVE 审中-公开
标题翻译: ÄÄTEL US AM ET UNG UNG UNG AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT公开(公告)号:EP2885270A1
公开(公告)日:2015-06-24
申请号:EP13753298.2
申请日:2013-08-12
申请人: L'Oréal
发明人: FADLI, Aziz
IPC分类号: C07C217/84 , C07D207/14 , C07D211/56 , C07D233/60 , C07D295/088 , A61K8/41 , A61K8/49 , A61Q5/10
CPC分类号: A61K8/4913 , A61K8/411 , A61K8/49 , A61K8/494 , A61K8/4946 , A61K2800/4322 , A61K2800/4324 , A61Q5/065 , A61Q5/10 , C07C217/84 , C07D207/14 , C07D211/56 , C07D233/60 , C07D295/088 , C09B57/00
摘要: The invention relates to a meta-phenylenediamine compound of formula (I) below, the addition salts thereof with an acid and the solvates thereof: in which: R represents a hydrogen or halogen atom; a C
1 -C
4 alkyl radical; a carboxyl radical or a (C
1 -C
4 ) alkoxycarbonyl radical, R
1 represents a linear C
1 -C
10 alkyl radical substituted with a cationic radical, said alkyl radical being optionally interrupted with one or more oxygen atoms and/or with one or more NR
6 groups, said cationic radical being optionally substituted with one or more radicals chosen from C
1 -C
4 alkoxy or C
1 -C
4 (hydroxy )alkyl; R
6 represents a hydrogen atom or a linear or branched C
1 -C
4 alkyl radical; An
- represents an anion or a mixture of anions which are organic or inorganic and cosmetically acceptable.摘要翻译: 本发明涉及以下式(I)的间苯二胺化合物,其与酸及其溶剂化物的加成盐:其中:R表示氢或卤素原子; C1-C4烷基; 羧基或(C 1 -C 4)烷氧基羰基,R 1表示被阳离子基团取代的直链C 1 -C 10烷基,所述烷基任选地被一个或多个氧原子和/或一个或多个NR 6基团中断, 所述阳离子基团任选被一个或多个选自C 1 -C 4烷氧基或C 1 -C 4(羟基)烷基的基团取代; R6表示氢原子或直链或支链C1-C4烷基; An-表示阴离子或阴离子的混合物,所述阴离子是有机或无机和化妆品可接受的。
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公开(公告)号:EP2000125A4
公开(公告)日:2014-09-03
申请号:EP07736891
申请日:2007-03-16
申请人: KAO CORP
发明人: FUKUHARA MASAKI , NISHI TAKAFUMI , FUJII YASUYUKI
IPC分类号: A61K8/49 , A61Q5/08 , A61Q5/10 , C07D207/14 , C07D211/56
CPC分类号: A61Q5/10 , A61K8/4913 , A61K8/4926 , A61Q5/08 , C07D207/14 , C07D211/56
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118.PYRROLIDIN-3-YL COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权
标题翻译: 用于治疗阿尔茨海默病SUITABLE吡咯烷-3-基的化合物的治疗ALSβ-分泌酶抑制剂公开(公告)号:EP1758854B1
公开(公告)日:2014-07-16
申请号:EP05758579.6
申请日:2005-06-10
发明人: COBURN, Craig, A.
IPC分类号: C07D207/14 , A61K31/40 , A61P25/28
CPC分类号: C07D207/14
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119.N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS 有权
标题翻译: N,N-取代的3-氨基吡咯烷化合物可用作单胺再用抑制剂公开(公告)号:EP1881975B8
公开(公告)日:2014-04-09
申请号:EP06756356.9
申请日:2006-05-12
发明人: KURIMURA, Muneaki , TAIRA, Shinichi , TOMOYASU, Takahiro , ITO, Nobuaki , TAI, Kuninori , TAKEMURA, Noriaki , MATSUZAKI, Takayuki , MENJO, Yasuhiro , MIYAMURA, Shin , SAKURAI, Yohji , WATANABE, Akihito , SAKATA, Yasuyo , MASUMOTO, Takumi , AKAZAWA, Kohei , SUGINO, Haruhiko , AMADA, Naoki , OHASHI, Satoshi , SHINOHARA, Tomoichi , SASAKI, Hirofumi , MORITA, Chisako , YAMASHITA, Junko , NAKAJIMA, Satoko
IPC分类号: C07D401/12 , C07D401/14 , C07D403/14 , C07D207/14 , C07D405/12 , C07D407/12 , A61K31/497 , A61K31/4439 , A61K31/40 , A61P25/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D407/14
CPC分类号: C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
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120.Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase IV and methods 有权
标题翻译: 二肽基肽酶IV和方法的吡咯烷基 - β-氨基酰胺类抑制剂公开(公告)号:EP2487154B1
公开(公告)日:2013-10-16
申请号:EP12166016.1
申请日:2006-10-30
IPC分类号: C07D207/06 , C07D207/14 , C07D401/06 , C07D403/06 , C07D413/06 , A61K31/40 , A61K31/422 , A61K31/4709 , A61K31/538 , A61K31/55 , A61P3/00 , C07D401/04 , C07D403/04 , C07D413/04 , C07D207/08
CPC分类号: C07D207/06 , C07D207/08 , C07D207/14 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D413/04 , C07D413/06
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