利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

269 条记录 (耗时 0.017 秒)

    CHELATING AGENTS AND THEIR METAL CHELATES FOR TREATING FREE RADICALS INDUCED CONDITIONS
    121.
    发明公开
    CHELATING AGENTS AND THEIR METAL CHELATES FOR TREATING FREE RADICALS INDUCED CONDITIONS 失效
    螯合物，METALCHELATE用于治疗由自由基引起STATES

    公开(公告)号：EP0936915A1

    公开(公告)日：1999-08-25

    申请号：EP97928369.0

    申请日：1997-06-24

    申请人： NYCOMED IMAGING AS

    发明人： KARLSSON, Jan, Olof, Gustav ,  JYNGE, Per ,  TOWART, Robertson

    IPC分类号： A61K45 ,  A61K31 ,  A61K33 ,  A61P39

    CPC分类号： A61K33/32 ,  A61K31/198 ,  A61K31/28 ,  A61K31/4415 ,  A61K31/444 ,  A61K31/675 ,  Y10S514/836 ,  A61K2300/00

    摘要： The invention provides the use of a compound of formula (I) or a metal chelate or salt thereof in the manufacture of a therapeutic agent for use in the treatment or prophylaxis of conditions resulting from the presence of free radicals in the human or non-human animal body (wherein in formula (I): each R1 independently represents hydrogen or -CH¿2?COR?5; R5¿ represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; each R2 independently represents a group XYR6; X represents a bond, or a C¿1-3? alkylene or oxoalkylene group optionally substituted by a group R?7¿; Y represents a bond, an oxygen atom or a group NR6; R6 is a hydrogen atom, a group COOR8, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR?8, CONR8¿2, NR82, OR8, =NR8, =O, OP(O) (OR8)R7 and OSO¿3M; R?7 is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R8 is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation; R3 represents a C¿1-8? alkylene group, a 1,2-cycloalkylene group, or a 1,2-arylene group; and each R?4¿ independently represents hydrogen or C¿1-3? alkyl). Such compounds are particularly effective in relieving symptoms associated with reperfusion of ischemic tissue and in treating or preventing radiation-induced injury.

    IODINATED X-RAY-CONTRAST MEDIA
    123.
    发明授权
    IODINATED X-RAY-CONTRAST MEDIA 失效
    碘化X射线造影剂

    公开(公告)号：EP0782565B1

    公开(公告)日：1999-04-07

    申请号：EP95932108.4

    申请日：1995-09-22

    申请人： NYCOMED IMAGING AS

    发明人： RYDBECK, Anna ,  ALMEN, Torsten ,  THANING, Mikkel ,  ANDERSSON, Sven ,  WISTRAND, Lars-Göran ,  GOLMAN, Klaes

    IPC分类号： C07C275/42 ,  C07C237/46 ,  C07C235/16 ,  A61K49/04

    CPC分类号： C07C237/46 ,  A61K49/0433 ,  C07C233/25 ,  C07C235/16 ,  C07C275/42

    摘要： The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula (I) (wherein each C6R5 moiety may be the same or different; each R denotes a hydrogen or iodine atom or a group M, two or three non-adjacent R groups on each C6R5 moiety denoting iodine atoms and one, two or three R groups on each C6R5 moiety denoting M groups; X denotes a group providing a 1, 2 or 3 atom chain linking the two C6R5 groups, preferably where X is or contains in the bridging chain a carbonyloxy group each C6R5 group being a triodophenyl group or a group in which each R is other than hydrogen; and each M is independently a non-ionic hydrophilic moiety, M preferably being a non-ionic hydrophilic moiety comprising a monohydroxy- or polyhydroxy-alkyl group) and isomers, especially stereoisomers and rotamers, thereof.

    Polyoxyethylene fatty acid ester surfactants and use thereof
    128.
    发明公开
    Polyoxyethylene fatty acid ester surfactants and use thereof 失效
    聚乙烯氧基聚乙烯酯和脱水剂Verwendung

    公开(公告)号：EP0844016A2

    公开(公告)日：1998-05-27

    申请号：EP97309505.2

    申请日：1997-11-25

    申请人： NYCOMED IMAGING AS

    发明人： Strande, Per ,  Dugstad, Harald ,  Balinov, Balin ,  Alfheim, Jan ,  Arukwe, Joseph

    IPC分类号： B01F17/34 ,  C08G65/02 ,  C07C69/02 ,  A61K7/00 ,  A61K9/00

    CPC分类号： C08G65/3322 ,  A61K8/39 ,  A61K8/86 ,  A61K47/14 ,  A61Q19/00 ,  B01F17/0028 ,  C07C69/96

    摘要： The present invention provides a polyethylene glycol (PEG) ester surfactant comprising at least one polyethylene glycol moiety and at least one fatty acyl moiety characterised in that said moieties are linked by a linkage incorporating a biodegradable methylene diester unit of formula (I)

            -CO.O.C(R 1 )(R 2 ).O.CO-     (I)

    where R 1 and R 2 may, for example, each be a hydrogen atom or a monovalent organic group attached through a carbon atom or R 1 and R 2 together may, for example, form a divalent organic group attached through carbon atoms.

    摘要翻译： 本发明提供了包含至少一个聚乙二醇部分和至少一个脂肪酰基部分的聚乙二醇（PEG）酯表面活性剂，其特征在于所述部分通过结合有式（I）-CO的可生物降解的亚甲基二酯单元的连接物连接。 OC（R 1）（R 2），O.CO-，其中R 1和R 2可以各自为氢原子或通过碳原子连接的一价有机基团或R 1和R 2一起可以例如形成通过碳原子连接的二价有机基团。